Publicou 4 edições por ano
ISSN Imprimir: 2155-014X
ISSN On-line: 2155-0158
Participation of Phosphatidylinositol-3'- kinase in Perception and Signal Transduction through Galactosyl- Containing Glycoprotein Receptors of Segmented Leukocytes under Type 1 Diabetes Mellitus
RESUMO
The reduced amount of glycoconjugate β,D-galactosyl-containing carbohydrate determinants on the cytoplasmatic membrane of segmented neutrophils (SN) of peripheral blood under type 1 diabetes mellitus (DM) has been shown to correlate with the changes in aggregation properties of these cells, and may cause their functional disorder. Changes in ricininduced neutrophil activation caused by phosphatidylinositol-3'-kinase (PI-3'-kinase) enzyme inhibition with Wortmannin indicate that the functional state of polymorphonuclear leukocytes is mediated by signaling pathways in which PI-3'-kinase is involved. Thus, PI-3'-kinase-dependent signal networks are involved in the processes of signal transduction through galactosyl- containing glycoprotein receptors into neutrophilic leukocytes. The temporal inertness of intensity of mature neutrophil response on Ricin communis lectin (RCA) -induced translocation of p85α regulatory subunit of PI-3'-kinase from the cytosolic to the membrane fraction under type 1 DM is a consequence of changes in either the number or the structure of plasmatic galactosyl-containing glycoprotein receptors. The revealed changes may be an etiological premise of diabetic complications and chronic diseases that impair the functional state of patients with type 1 DM.