Publicou 12 edições por ano
ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344
Indexed in
Activity of Crude Cold-Water Extract of the Culinary-Medicinal Oyster Mushroom, Pleurotus ostreatus (Jacq.:Fr.) P.Kumm. (Higher Basidiomycetes), and Timolol Maleate on Induced Ocular Hypertension
RESUMO
Aqueous crude cold-water extract from the fruiting body of the culinary-medicinal oyster mushroom Pleurotus ostreatus was assessed for activity against increased intra-ocular pressure (IOP) in mice. A 0.1% dexamethasone instillation was used to raise the intra-ocular pressure in the animals above the 21-mmHg threshold limit. The extract has intrinsic anti-hypertensive properties that are dose dependent. A comparison analysis indicated that 150 mg/mL of the crude extract produced 57.69% reduction in the intra-ocular pressure, while doses of 100 mg/ mL and 200 mg/mL produced 44.78% and 70.03% IOP reduction, respectively, compared with timolol maleate with 57.69%. The results were significant at 0.05 confidence limit (p < 0.05) when compared to a placebo and therefore support its use for the treatment of increased intra-ocular pressure.
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Geng Xueran, Tian Guoting, Zhang Weiwei, Zhao Yongchang, Zhao Liyan, Ryu Mansok, Wang Hexiang, Ng Tzi, Isolation of an Angiotensin I-Converting Enzyme Inhibitory Protein with Antihypertensive Effect in Spontaneously Hypertensive Rats from the Edible Wild Mushroom Leucopaxillus tricolor, Molecules, 20, 6, 2015. Crossref
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Hartonen Kari, Riekkola Marja-Liisa, Water as the First Choice Green Solvent, in The Application of Green Solvents in Separation Processes, 2017. Crossref
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Carrasco-González Jorge Alberto, Serna-Saldívar Sergio O., Gutiérrez-Uribe Janet A., Nutritional composition and nutraceutical properties of the Pleurotus fruiting bodies: Potential use as food ingredient, Journal of Food Composition and Analysis, 58, 2017. Crossref
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Ali Khursheed, Cherian Tijo, Fatima Saher, Saquib Quaiser, Faisal Mohammad, Alatar Abdulrahman A., Musarrat Javed, Al-Khedhairy Abdulaziz A., Role of Solvent System in Green Synthesis of Nanoparticles, in Green Synthesis of Nanoparticles: Applications and Prospects, 2020. Crossref