Publicou 12 edições por ano
ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344
Indexed in
Immune-Competent Polysaccharides from the Submerged Cultured Mycelium of CulinaryMedicinal Mushroom Lentinus strigellus Berk. et Curt. (Agaricomycetideae)
RESUMO
Two main fractions of polysaccharide SL-I and SL-II-b were purified from submerged cultured mycelium of culinarymedicinal mushroom Lentinus strigellus using hot water extraction, ethanol precipitation, DEAE-cellulose chromatography, and Sephadex G-100 filtration. Polysaccharide analysis showed that SL-I is a protein-free polysaccharide with 1.15 × 104 Da molecular weight and +63.33° optical rotation, while SL-II-b is a protein-conjugated polysaccharide with 3.88 × 103 Da molecular weight and +73.67° optical rotation. The sugar constituents of polysaccharide analysis by GC showed that both fractions are heteropolysaccharides. SL-I consists of six monosaccharides, and SL-II-b consists of three monosaccharides. IR and 1H-NMR, 13C-NMR spectra further indicated that LS-I and LS-II-b are heteropolysaccharides with a(1®2),(1®4) glucosidic bonds (LS-I), and a(1®2),(1®3),(1®4) glucosidic bonds (LS-II-b). The immune-competent examination showed that both polysaccharides could increase the spleen index, carbon clearance index, phagocytic index, and white blood cell levels of CY-treated mice.
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El-Enshasy H., Daba A., El-Demella M., Ibrahim A., El Sayed S., El-Badry I., Bioprocess Development for Large Scale Production of Anticancer Exo-Polysaccharide by Pleurotus ostreatus in Submerged Culture, Journal of Applied Sciences, 10, 21, 2010. Crossref
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Barros-Filho Bartholomeu A., de Oliveira Maria da Conceição F., Lemos Telma L.G., de Mattos Marcos C., Gonzalo Gonzalo de, Gotor-Fernández Vicente, Gotor Vicente, Lentinus strigellus: a new versatile stereoselective biocatalyst for the bioreduction of prochiral ketones, Tetrahedron: Asymmetry, 20, 9, 2009. Crossref
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De Silva Dilani D., Rapior Sylvie, Fons Françoise, Bahkali Ali H., Hyde Kevin D., Medicinal mushrooms in supportive cancer therapies: an approach to anti-cancer effects and putative mechanisms of action, Fungal Diversity, 55, 1, 2012. Crossref
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Julca-Canto María, Aguilar-Pérez Madelaine M., Rios Nivia, Sousa João Paulo B., Cubilla-Rios Luis, Additional new natural products produced by Lentinus strigellus: a biotechnological approach, Tetrahedron Letters, 57, 6, 2016. Crossref
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Barros-Filho Bartholomeu A., de Oliveira Maria C. F., Mafezoli Jair, Barbosa Francisco G., Rodrigues-Filho Edson, Secondary Metabolite Production by the Basidiomycete, Lentinus strigellus, under Different Culture Conditions, Natural Product Communications, 7, 6, 2012. Crossref
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Hyder Md Salman, Dutta Sayan Deb, Mushroom-derived polysaccharides as antitumor and anticancer agent: A concise review, Biocatalysis and Agricultural Biotechnology, 35, 2021. Crossref