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International Journal of Medicinal Mushrooms

Publicou 12 edições por ano

ISSN Imprimir: 1521-9437

ISSN On-line: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Effect of Ling Zhi or Reishi Mushroom Ganoderma lucidum (W. Curt.: Fr.) P. Karst. Mycelium on Benzo[a]prene-Induced Early Alterations of the Respiratory Epithelium in the Hypercholesterolaemic Rats

Volume 9, Edição 2, 2007, pp. 139-150
DOI: 10.1615/IntJMedMushr.v9.i2.40
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RESUMO

Many research studies indicate that fractions from the culture medium of Ganoderma lucidum mycelium (GM) have an antitumor activity through immunostimulation. There is a growing need for a short-term, cost-effective bioassay to assess the efficacy of potential antitumor agents from GM. Twenty-five Spraque-Dawley rats were divided into 5 groups according to their different feed. The positive control and negative control groups were given basal rat chew. The cholesterol (Chol) group was fed a 1% cholesterol diet, and the GM group was fed a 10% GM diet, whereby 1% Chol and 10% GM powder was added to the cholesterol plus G. lucidum mycelium (Chol+GM) group diet, respectively. All the rats were sacrificed 3 months after instillation with 13 ng of benzo[a]prene (B(a)P), except the negative control group. The lung sections were preserved for histological examination, and the glutathione S-transferase (GST) level was measured. Supplementation with GM had no significant effect on the increasing ratio of lung weight to body weight of the rats. The level of GST was significantly lower in both the Chol and positive control groups compared to the other groups. In the Chol+GM group, no significant lesions were observed in the lungs. No significant gross pathological changes were observed in the lungs of the negative control, GM, or Chol+GM groups. However, small whitish nodules were observed in the lungs of 3 rats from the positive control group and on both lungs in all rats from the Chol group. The study reported herein showed that GM is an effective treatment in inhibiting B(a)P-induced carcinogenesis in rats.

CITADO POR
  1. Tong Chow-Chin, Choong Yew-Keong, Umar Nor-Aini-B, Noordin Mohamed-Mustapha, Mohamed Suhaila, Cytotoxic activity induced by crude extracts of Ganoderma lucidum (W. Curt.: Fr.) P. Karst. on mouse myeloma cancer cell-line, World Journal of Microbiology and Biotechnology, 25, 4, 2009. Crossref

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