Publicou 12 edições por ano
ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344
Indexed in
Immune-Modulating Activity of Extract Prepared from Mycelial Culture of Chinese Caterpillar Mushroom, Ophiocordyceps sinensis (Ascomycetes)
RESUMO
Ophiocordyceps sinensis is a natural fungus that has been valued as a health food and traditional Chinese medicine for centuries. The fungus is parasitic and colonizes insect larva. Naturally occurring O. sinensis thrives at high altitude in cold and grassy alpine meadows on the Himalayan mountain ranges. Wild O. sinensis is becoming increasingly rare in its natural habitats, and its price is out of reach for clinical practice. For these reasons, development of a standardized alternative is a great focus of research to allow the use of O. sinensis as a medicine. To develop an alternative for wild O. sinensis, a refined standardized extract, CBG-CS-2, was produced by artificial fermentation and extraction of the mycelial strain Paecilomyces hepiali CBG-CS-1, which originated from wild O. sinensis. In this study, we analyzed the in vivo immune-modulating effect of CBG-CS-2 in mice. Oral administration of CBG-CS-2 supported splenocyte stimulation and enhanced Th1-type cytokine expression from the splenocytes. Importantly, the same treatment significantly enhanced the natural killer cell activity of the splenocytes. Finally, oral administration of CBG-CS-2 enhanced the potential for inflammatory responses. Together, these findings indicate that the mycelial culture extract prepared from O. sinensis exhibited immune-modulating activity and suggest its possible use in the treatment of diseases caused by abnormal immune function.
-
Jang Sun-Hee, Park Jisang, Jang Seung-Hwan, Chae Soo-Wan, Jung Su-Jin, So Byung-Ok, Ha Ki-Chan, Sin Hong-Sig, Jang Yong-Suk, In vitro Stimulation of NK Cells and Lymphocytes Using an Extract Prepared from Mycelial Culture of Ophiocordyceps sinensis, Immune Network, 16, 2, 2016. Crossref
-
Jung Su-Jin, Jung Eun-Soo, Choi Eun-Kyung, Sin Hong-Sig, Ha Ki-Chan, Chae Soo-Wan, Immunomodulatory effects of a mycelium extract of Cordyceps (Paecilomyces hepiali; CBG-CS-2): a randomized and double-blind clinical trial, BMC Complementary and Alternative Medicine, 19, 1, 2019. Crossref
-
Kaushik Vikas, Singh Amanvir, Arya Aditi, Sindhu Sangeeta Chahal, Sindhu Anil, Singh Ajay, Enhanced production of cordycepin in Ophiocordyceps sinensis using growth supplements under submerged conditions, Biotechnology Reports, 28, 2020. Crossref
-
Liu Hao, Wang Zi-Ying, Zhou Yu-Cong, Song Wei, Ali Usman, Sze Daniel M.-Y, Immunomodulation of Chinese Herbal Medicines on NK cell populations for cancer therapy: A systematic review, Journal of Ethnopharmacology, 268, 2021. Crossref
-
Yuan Qianghua, Xie Fan, Tan Jing, Yuan Yan, Mei Hu, Zheng Yan, Sheng Rong, Extraction, structure and pharmacological effects of the polysaccharides from Cordyceps sinensis: A review, Journal of Functional Foods, 89, 2022. Crossref