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International Journal of Medicinal Mushrooms

Publicou 12 edições por ano

ISSN Imprimir: 1521-9437

ISSN On-line: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Immune-Modulating Activity of Extract Prepared from Mycelial Culture of Chinese Caterpillar Mushroom, Ophiocordyceps sinensis (Ascomycetes)

Volume 17, Edição 12, 2015, pp. 1189-1199
DOI: 10.1615/IntJMedMushrooms.v17.i12.90
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RESUMO

Ophiocordyceps sinensis is a natural fungus that has been valued as a health food and traditional Chinese medicine for centuries. The fungus is parasitic and colonizes insect larva. Naturally occurring O. sinensis thrives at high altitude in cold and grassy alpine meadows on the Himalayan mountain ranges. Wild O. sinensis is becoming increasingly rare in its natural habitats, and its price is out of reach for clinical practice. For these reasons, development of a standardized alternative is a great focus of research to allow the use of O. sinensis as a medicine. To develop an alternative for wild O. sinensis, a refined standardized extract, CBG-CS-2, was produced by artificial fermentation and extraction of the mycelial strain Paecilomyces hepiali CBG-CS-1, which originated from wild O. sinensis. In this study, we analyzed the in vivo immune-modulating effect of CBG-CS-2 in mice. Oral administration of CBG-CS-2 supported splenocyte stimulation and enhanced Th1-type cytokine expression from the splenocytes. Importantly, the same treatment significantly enhanced the natural killer cell activity of the splenocytes. Finally, oral administration of CBG-CS-2 enhanced the potential for inflammatory responses. Together, these findings indicate that the mycelial culture extract prepared from O. sinensis exhibited immune-modulating activity and suggest its possible use in the treatment of diseases caused by abnormal immune function.

CITADO POR
  1. Jang Sun-Hee, Park Jisang, Jang Seung-Hwan, Chae Soo-Wan, Jung Su-Jin, So Byung-Ok, Ha Ki-Chan, Sin Hong-Sig, Jang Yong-Suk, In vitro Stimulation of NK Cells and Lymphocytes Using an Extract Prepared from Mycelial Culture of Ophiocordyceps sinensis, Immune Network, 16, 2, 2016. Crossref

  2. Jung Su-Jin, Jung Eun-Soo, Choi Eun-Kyung, Sin Hong-Sig, Ha Ki-Chan, Chae Soo-Wan, Immunomodulatory effects of a mycelium extract of Cordyceps (Paecilomyces hepiali; CBG-CS-2): a randomized and double-blind clinical trial, BMC Complementary and Alternative Medicine, 19, 1, 2019. Crossref

  3. Kaushik Vikas, Singh Amanvir, Arya Aditi, Sindhu Sangeeta Chahal, Sindhu Anil, Singh Ajay, Enhanced production of cordycepin in Ophiocordyceps sinensis using growth supplements under submerged conditions, Biotechnology Reports, 28, 2020. Crossref

  4. Liu Hao, Wang Zi-Ying, Zhou Yu-Cong, Song Wei, Ali Usman, Sze Daniel M.-Y, Immunomodulation of Chinese Herbal Medicines on NK cell populations for cancer therapy: A systematic review, Journal of Ethnopharmacology, 268, 2021. Crossref

  5. Yuan Qianghua, Xie Fan, Tan Jing, Yuan Yan, Mei Hu, Zheng Yan, Sheng Rong, Extraction, structure and pharmacological effects of the polysaccharides from Cordyceps sinensis: A review, Journal of Functional Foods, 89, 2022. Crossref

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