Characterization of the Effects of the Shiitake Culinary-Medicinal Mushroom, <i>Lentinus edodes</i> (Agaricomycetes), on Severe Gestational Diabetes Mellitus in Rats

Bianca Hessel  Maschio; Bianca Carvalho  Gentil; Erika Leão Ajala  Caetano; Lucas Silva  Rodrigues; Leticia Favara  Laurino; Sara Rosicler Vieira  Spim; Angela Faustino  Jozala; Carolina Alves  dos Santos; Denise Grotto; Marli Gerenutti

doi:10.1615/IntJMedMushrooms.2017024498

International Journal of Medicinal Mushrooms

Editor chefe: Solomon P. Wasser (open in a new tab)

Publicou 12 edições por ano

ISSN Imprimir: 1521-9437

ISSN On-line: 1940-4344

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Characterization of the Effects of the Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), on Severe Gestational Diabetes Mellitus in Rats

Volume 19, Edição 11, 2017, pp. 991-1000

DOI: 10.1615/IntJMedMushrooms.2017024498

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Bianca Hessel Maschio
Post Graduate Program in Pharmaceutical Sciences, Department of Development and Evaluation of Bioactive Substances, University of Sorocaba, SP, Brazil; Laboratory of Toxicological Research (Lapetox), University of Sorocaba, UNISO, Sorocaba, SP, Brazil

Bianca Carvalho Gentil
Laboratory of Toxicological Research (Lapetox), University of Sorocaba, UNISO, Sorocaba, SP, Brazil

Erika Leão Ajala Caetano
Post Graduate Program in Pharmaceutical Sciences, Department of Development and Evaluation of Bioactive Substances, University of Sorocaba, SP, Brazil; Laboratory of Toxicological Research (Lapetox), University of Sorocaba, UNISO, Sorocaba, SP, Brazil

Lucas Silva Rodrigues
Laboratory of Toxicological Research (Lapetox), University of Sorocaba, UNISO, Sorocaba, SP, Brazil

Leticia Favara Laurino
Post Graduate Program in Pharmaceutical Sciences, Department of Development and Evaluation of Bioactive Substances, University of Sorocaba, SP, Brazil; Laboratory of Toxicological Research (Lapetox), University of Sorocaba, UNISO, Sorocaba, SP, Brazil

Sara Rosicler Vieira Spim
Post Graduate Program in Pharmaceutical Sciences, Department of Development and Evaluation of Bioactive Substances, University of Sorocaba, SP, Brazil; Laboratory of Toxicological Research (Lapetox), University of Sorocaba, UNISO, Sorocaba, SP, Brazil

Angela Faustino Jozala
Laboratory of Toxicological Research (Lapetox), University of Sorocaba, UNISO, Sorocaba, SP, Brazil; Department of Technological and Environmental Processes, University of Sorocaba, UNISO, Sorocaba, SP, Brazil

Carolina Alves dos Santos
Post Graduate Program in Pharmaceutical Sciences, Department of Development and Evaluation of Bioactive Substances, University of Sorocaba, SP, Brazil

Denise Grotto
University of Sorocaba (UNISO), Rodovia Raposo Tavares Km 92.5, CEP. 18023-000, Sorocaba, Brazil SP, Brazil

Marli Gerenutti
Post Graduate Program in Pharmaceutical Sciences, Department of Development and Evaluation of Bioactive Substances, University of Sorocaba, SP, Brazil; Laboratory of Toxicological Research (Lapetox), University of Sorocaba, UNISO, Sorocaba, SP, Brazil; Department of Technological and Environmental Processes, University of Sorocaba, UNISO, Sorocaba, SP, Brazil

RESUMO

This study evaluated the protective effect of Lentinus edodes in rats with streptozotocin-induced gestational diabetes mellitus (STZ-GDM) when administered orally. The rats received from the 1st to the 19th day of gestation daily doses of 100 or 200 mg/kg of lyophilized and reconstituted L. edodes; the animals in the saline control group and diabetic control group received a saline solution (DS). Gestational diabetes mellitus was induced by streptozotocin (80 mg/kg, administered intraperitoneally) on the fourth day of pregnancy; blood glucose > 180 mg/dL was considered to indicate STZ-GDM. L. edodes reduced catalase in plasma. We also observed reduced glucose in plasma, urea, triglycerides, and aspartate aminotransferase. There was a decrease in preimplantation loss when compared with the DS group. The doses of L. edodes used here had a protective effect on the preimplantation parameters in STZGDM. However, the mushroom was not able to reverse the deleterious effects caused by streptozotocin throughout the evolution of pregnancy.

Palavras-chave: food safety, gestational diabetes mellitus, Lentinus edodes, medicinal mushrooms, reproductive toxicology

CITADO POR

Yang Hye, Kim Min, Kwon Dae, Kim Da, Zhang Ting, Ha Chulgyu, Park Sunmin, Combination of Aronia, Red Ginseng, Shiitake Mushroom and Nattokinase Potentiated Insulin Secretion and Reduced Insulin Resistance with Improving Gut Microbiome Dysbiosis in Insulin Deficient Type 2 Diabetic Rats, Nutrients, 10, 7, 2018. Crossref
Laurino Leticia, Viroel Fabia, Caetano Erika, Spim Sara, Pickler Thaisa, Rosa-Castro Raquel, Vasconcelos Edilma, Jozala Angela, Hataka Alessandre, Grotto Denise, Gerenutti Marli, Lentinus edodes Exposure before and after Fetus Implantation: Materno-Fetal Development in Rats with Gestational Diabetes Mellitus, Nutrients, 11, 11, 2019. Crossref
Gulati Vandana, Dass Singh Mansi, Gulati Pankaj, Role of mushrooms in gestational diabetes mellitus, AIMS Medical Science, 6, 1, 2019. Crossref
Yang Dengyu, Wang Tiancheng, Long Miao, Li Peng, Quiles Jos L., Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine, Oxidative Medicine and Cellular Longevity, 2020, 2020. Crossref
Ingole Ashwini, Kadam Megha P, Dalu Aishwarya P., Kute Shital M, Mange Piyusha R, Theng Vaishali D, Lahane Om R, Nikas Aniket P, Kawal Yash V, Nagrik Shatrughna U., Patil Prashant A., A Review of the Pharmacological Characteristics of Vanillic Acid, Journal of Drug Delivery and Therapeutics, 11, 2-S, 2021. Crossref

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