Inscrição na biblioteca: Guest
International Journal of Medicinal Mushrooms

Publicou 12 edições por ano

ISSN Imprimir: 1521-9437

ISSN On-line: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

Indexed in

Activation of NADPH Oxidase by β-Glucan from Phellinus baumii (Agaricomycetes) in RAW 264.7 Cells

Volume 19, Edição 11, 2017, pp. 957-965
DOI: 10.1615/IntJMedMushrooms.2017024620
Get accessGet access

RESUMO

Production of oxygen-derived free radicals in phagocytes is important in preventing bacterial and fungal infections. Among free radicals, superoxide anions are a typical reactive oxygen species secreted by macrophages and neutrophils. NADPH oxidase (NOX) is a key producer of superoxide anions in these cells. β-glucans from mushrooms modulate the immune system by binding with the dectin-1 receptor on macrophages. Dectin-1 functions as a pattern recognition receptor that recognizes the pathogen-associated molecular pattern of β-glucans. During dectin-1 signaling, NOX functions in the activated macrophages to produce ROS, which are critical in antimicrobial host defense. In this study, NOX activation was measured using a lucigenin chemiluminescence assay in RAW 264.7 murine macrophages treated for 1 hour with a β-glucan fraction from Phellinus baumii (BGF; 10, 100, 500, and 1000 μg/mL) in the absence or presence of phorbol 12-myristate 13-acetate (PMA) or lipopolysaccharide (LPS). NOX was activated at BGF concentrations exceeding 10 μg/mL. BGF in the presence of PMA or LPS activated the enzyme more than treatment with PMA or LPS alone. In the presence of the NOX inhibitor diphenyleneiodonium, BGF still activated NOX. When macrophages were treated with BGF and Staphylococcus aureus, bacterial viability was reduced in a concentration-dependent manner, possibly as a result of increased phagocytosis and oxygen radical production by the activated NOX. These results demonstrate that BGF is a potent stimulator of NOX in macrophages and augments macrophage-mediated phagocytosis and NOX activity.

CITADO POR
  1. Zhou Lishan, Tang Jianqiao, Yang Xuan, Dong Hui, Xiong Xiaoli, Huang Juan, Zhang Linli, Qin Huan, Yan Suqi, Five Constituents in Psoralea corylifolia L. Attenuate Palmitic Acid-Induced Hepatocyte Injury via Inhibiting the Protein Kinase C-α/Nicotinamide-Adenine Dinucleotide Phosphate Oxidase Pathway, Frontiers in Pharmacology, 10, 2020. Crossref

  2. Lee Sun Jung, Lee Dong Hee, Kim Ha Won, Novel Antihypertension Mechanism of β-Glucan by Corin and ANP-Mediated Natriuresis in Mice, Mycobiology, 48, 5, 2020. Crossref

  3. Dong Haoran, Chen Hui, Xu Bing, Tan Yingru, Ling Qun, Shi Liang, Citric Acid Changes the Fingerprint of Flavonoids and Promotes Their Accumulation in Phellinus igniarius (L.) Quél, Life, 13, 1, 2022. Crossref

905 Visualizações do artigo 30 downloads de artigos Métricas
905 VISUALIZAÇÕES 30 TRANSFERÊNCIAS 3 Crossref CITAÇÕES Google
Scholar
CITAÇÕES

Artigos com conteúdo semelhante:

Cooperative Effect of the Lipopolysaccharide and Culinary-Medicinal Cauliflower Mushroom Sparassis crispa (Wulf.) Fr. (Aphyllophoromycetideae)-Derived β-Glucan on Inflammatory Cytokine Secretion by the Murine Macrophage Cell Line International Journal of Medicinal Mushrooms, Vol.11, 2009, issue 1
Ha Won Kim, Sung In Kim, In Soo Ko, Hyuk Gu Park, Gye Hyung Cho
Hot Water Extract of the Sclerotium of Polyporus rhinocerus Cooke Enhances the Immune Functions of Murine Macrophages International Journal of Medicinal Mushrooms, Vol.13, 2011, issue 3
Cuixia Guo, Ka-Hing Wong, Peter Chi Keung Cheung
Medicinal Mushroom Lingzhi or Reishi, Ganoderma lucidum (W.Curt.:Fr.) P. Karst., β-Glucan Induces Toll-like Receptors and Fails to Induce Inflammatory Cytokines in NF-κB Inhibitor-Treated Macrophages International Journal of Medicinal Mushrooms, Vol.13, 2011, issue 3
Mi Jeong Kim, Ha Won Kim, Sainkhuu Batbayar
An Immunomodulating Polysaccharide in Agaricus brasiliensis S. Wasser et al. (Agaricomycetideae) Activates Macrophages through Toll-like Receptor 4 International Journal of Medicinal Mushrooms, Vol.8, 2006, issue 3
Sachiko Kawakami, Masashi Mizuno
Ganoderma lucidum (Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) Inhibits Proliferation of Human Peripheral Blood Lymphocytes by Blocking lnterleukin-2 Secretion International Journal of Medicinal Mushrooms, Vol.2, 2000, issue 4
Ha Won Kim, Byong Kak Kim, Mi Ja Shim
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa Políticas de preços e assinaturas Begell House Contato Language English 中文 Русский Português German French Spain