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International Journal of Medicinal Mushrooms

Publicou 12 edições por ano

ISSN Imprimir: 1521-9437

ISSN On-line: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Composition Analysis and Immunomodulatory Capacity of Peptidoglycan from Ling Zhi or Reishi Medicinal Mushroom, Ganoderma lucidum (W. Curt.: Fr.) P. Karst. Strain 119 (Aphyllophoromycetideae)

Volume 12, Edição 2, 2010, pp. 157-165
DOI: 10.1615/IntJMedMushr.v12.i2.60
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RESUMO

LZ-B-1, a water-soluble peptidoglycan, was prepared from the fruiting bodies of Ling Zhi or Reishi medicinal mushroom, Ganoderma lucidum, by ultrafiltration, DEAE-Sepharose Fast-Flow column, and Sepharose CL-6B column. To develop functional food or pharmaceuticals using LZ-B-1 and to investigate the relationship between the structure and bioactivity of LZ-B-1, the composition and immunomodulatory capacity of LZ-B-1 were studied herein. The peptidoglycan had a relative molecular weight of 1.12 × 104 Da, and total carbohydrate and peptide percentages were determined to be ∼94.2% and ∼5.4%, respectively. The carbohydrate moiety was mainly composed of L-fucose, D-galatose, and D-glucose in a molar ratio of approximately 1:5:2, together with small amounts of L-arabinose and D-mannose. The peptide moiety mainly contained arginine, threonine, glycine, serine, and aspartic acid in a molar ratio of approximately 1:1:2:2:1. Methylation reaction and GC-MS analysis indicated that the carbohydrate moiety mainly consisted of 1,6-disubstituted-galactopyranosyl, 1,2,6-trisubstituted-galactopyranosyl, 1-substituted-fucopyranosyl, 1,3-disubstituted- glucopyranosyl, 1,4,6-trisubstituted-glucopyranosyl, and 1-substituted-glucopyranosyl. Mouse spleen cell proliferation assay in vitro showed that a concentration of 200 μg/mL of LZ-B-1 was the optimum concentration to promote the proliferation of mouse spleen lymphocytes (MSLs). In general, the higher the mouse spleen cell proliferation rate, the stronger the immunomodulatory activity. How the peptidoglycan stimulates the proliferation of MSLs and the bioactivity-structure relationship requires more research.

CITADO POR
  1. Zhang Jiao-Jiao, Li Ya, Zhou Tong, Xu Dong-Ping, Zhang Pei, Li Sha, Li Hua-Bin, Bioactivities and Health Benefits of Mushrooms Mainly from China, Molecules, 21, 7, 2016. Crossref

  2. Lv Guang-ping, Zhao Jing, Duan Jin-ao, Tang Yu-ping, Li Shao-ping, Comparison of sterols and fatty acids in two species of Ganoderma, Chemistry Central Journal, 6, 1, 2012. Crossref

  3. Raman Jegadeesh, Lakshmanan Hariprasath, Hyun-Jae Shin, Jang Kab-yel, The Nutritional and Pharmacological Potential of Medicinal Mushroom “Ganoderma lucidum (Lingzhi or Reishi)”, in Biology, Cultivation and Applications of Mushrooms, 2022. Crossref

  4. Kumar Abhiram, Sakhare Kalyani, Bhattacharya Dwaipayan, Chattopadhyay Raktim, Parikh Purvish, Narayan Kumar P., Mukherjee Anubhab, Communication in non-communicable diseases (NCDs) and role of immunomodulatory nutraceuticals in their management, Frontiers in Nutrition, 9, 2022. Crossref

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