Publicou 12 edições por ano
ISSN Imprimir: 1521-9437
ISSN On-line: 1940-4344
IF:
1.2
5-Year IF:
1.4
Immediacy Index:
0.3
Eigenfactor:
0.00066
JCI:
0.34
SJR:
0.274
SNIP:
0.41
CiteScore™::
2.8
H-Index:
37
Indexed in
In Vitro and In Vivo Antitumoral Activity of Exobiopolymers from the Royal Sun Culinary-Medicinal Mushroom Agaricus brasiliensis (Agaricomycetes)
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RESUMO
We studied antitumor activity in vitro and in vivo and partial chemical characterization of exobiopolymers (EBPs) of Agaricus brasiliensis produced by submerged cultivation. The EBPs comprised 61.2% total sugar and 22.3% total protein, and the chromatographic profile mainly identified mannose (65.5%), galactose (17.5%), and glucose (13.1%). In vitro analysis revealed a dose with antitumor effectiveness, time-dependent treatment, and 46% inhibition of solid Walker 256 tumors in rats. Metabolic changes were significant in the spleens of the animals; this is possibly related to higher immune activity triggered by the presence of EBPs in the treated group. The increase of nitric oxide production by peritoneal macrophages from animals may be related to the tumor reduction observed, because nitric oxide acts as an important effector pathway in the defense of the organism.
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Hetland Geir, Tangen Jon-Magnus, Mahmood Faiza, Mirlashari Mohammad Reza, Nissen-Meyer Lise Sofie Haug, Nentwich Ivo, Therkelsen Stig Palm, Tjønnfjord Geir Erland, Johnson Egil, Antitumor, Anti-inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifola frondosa: A Review of Preclinical and Clinical Studies, Nutrients, 12, 5, 2020. Crossref
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Liang Jingjing, Zhang Meina, Wang Xingnan, Ren Yichen, Yue Tianli, Wang Zhouli, Gao Zhenpeng, Edible fungal polysaccharides, the gut microbiota, and host health, Carbohydrate Polymers, 273, 2021. Crossref
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Câmara Neto João Francisco, Campelo Matheus da Silva, Cerqueira Gilberto Santos, de Miranda João Antônio Leal, Guedes Jhonyson Arruda Carvalho, de Almeida Raimundo Rafael, Soares Sandra de Aguiar, Gramosa Nilce Viana, Zocolo Guilherme Julião, Vieira Ícaro Gusmão Pinto, Ricardo Nágila Maria Pontes Silva, Ribeiro Maria Elenir Nobre Pinho, Gastroprotective effect of hydroalcoholic extract from Agaricus blazei Murill against ethanol-induced gastric ulcer in mice, Journal of Ethnopharmacology, 292, 2022. Crossref