Inscrição na biblioteca: Guest
International Journal of Medicinal Mushrooms

Publicou 12 edições por ano

ISSN Imprimir: 1521-9437

ISSN On-line: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

Indexed in

Ethyl Acetate Extracts of Submerged Cultured Mycelium of Higher Basidiomycetes Mushrooms Inhibit Human Ovarian Cancer Cell Growth

Volume 11, Edição 1, 2009, pp. 29-37
DOI: 10.1615/IntJMedMushr.v11.i1.40
Get accessGet access

RESUMO

Higher Basidiomycetes mushrooms (HBM) are a well-known source of anticancer agents, yet few works have evaluated the effectiveness of HBM metabolites against ovarian cancer. In the present study, 22 strains of HBM belonging to 19 species were grown under submerged conditions. Biomasses were dried, ground, and extracted by three different organic solvents: chloroform, ethanol, and ethyl acetate in an attempt to extract low-molecular-weight substances. These 66 extracts were screened for their effect on the viability of ovarian cancer cells (ES-2) in vitro. Four ethyl acetate extracts of Coprinus comatus, Grifola frondosa, Hypsizygus marmoreus, and Phellinus igniarius were found to be most effective, with IC50 ≤ 25 μg/mL, and were used for further evaluations. It was found that all four ethyl acetate extracts were active against other ovarian cancer cell lines: SKOV-3 and SW-626. The results indicated that the ES-2 cells revealed more anticancer activity of the extracts, in comparison to SKOV-3 and SW-626 cells. The reduction in ES-2 cell survival reached almost 100% at a concentration of 75−100 μg/mL, in all cases, whereas the reduction in SKOV-3 and SW-626 survival, at the same concentrations, was 50%−70%. All selected extracts were tested for toxicity and were nontoxic at the tested concentrations. Our results show that ethyl acetate extracts of the HBM strains studied reduced the viability of human ovarian cancer cells.

CITADO POR
  1. Wasser Solomon P., Current findings, future trends, and unsolved problems in studies of medicinal mushrooms, Applied Microbiology and Biotechnology, 89, 5, 2011. Crossref

  2. Suárez Arango Carolina, Nieto Ivonne Jeannette, Cultivo biotecnológico de macrohongos comestibles: una alternativa en la obtención de nutracéuticos, Revista Iberoamericana de Micología, 30, 1, 2013. Crossref

  3. Beattie Karren D., Ulrich Rahel, Grice I. Darren, Uddin Shaikh J., Blake Tony B., Wood Kyle A., Steele Jules, Iu Fontaine, May Tom W., Tiralongo Evelin, Ethanolic and aqueous extracts derived from Australian fungi inhibit cancer cell growth in vitro, Mycologia, 103, 3, 2011. Crossref

  4. Yan Pei Sheng, Zhu Guo Zhen, Cao Li Xin, Dong Jing, Optimizing the Medium for High Yield Production of Antitumor Exopolysaccharide by Medicinal Mushroom, Advanced Materials Research, 343-344, 2011. Crossref

  5. Vetchinkina Elena, Fomin Alexander, Navolokin Nikita, Shirokov Alexander, Proteins and polysaccharides from vegetative mycelium of medicinal basidiomycete Lentinus edodes display cytotoxicity towards human and animal cancer cell lines, International Journal of Biological Macromolecules, 195, 2022. Crossref

1372 Visualizações do artigo 53 downloads de artigos Métricas
1372 VISUALIZAÇÕES 53 TRANSFERÊNCIAS 5 Crossref CITAÇÕES Google
Scholar
CITAÇÕES

Artigos com conteúdo semelhante:

Evaluation of Antibacterial Potential of Two Species of Genus Agaricus L: Fr. (Agaricomycetideae) from India International Journal of Medicinal Mushrooms, Vol.10, 2008, issue 2
Inder S. Rana, Sardul S. Sandhu, Aarti Kanojiya
Inhibitory Effect of Ethyl Acetate Extract of the Shaggy Inc Cap Medicinal Mushroom, Coprinus comatus (Higher Basidiomycetes) Fruit Bodies on Cell Growth of Human Ovarian Cancer International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 5
Abed Agbarya, Solomon P. Wasser, Amal Rouhana-Toubi, Fuad Fares
The Effect of Culture Liquid Ethyl Acetate Mycelium Extracts of Medicinal Mushrooms on the Viability of Human Pancreatic Cancer Cells International Journal of Medicinal Mushrooms, Vol.14, 2012, issue 2
Solomon P. Wasser, Lital E. Sharvit, Fuad Fares
Anticancer and Antimicrobial Activities and Chemical Composition of the Birch Mazegill Mushroom Lenzites betulina (Higher Basidiomycetes) International Journal of Medicinal Mushrooms, Vol.16, 2014, issue 4
Qian Wang, Le Zhao, Kun Liu, Jun-Li Wang
Inhibitory Effects of a Polysaccharide Extract from the Chaga Medicinal Mushroom, Inonotus obliquus (Higher Basidiomycetes), on the Proliferation of Human Neurogliocytoma Cells International Journal of Medicinal Mushrooms, Vol.16, 2014, issue 1
Qi Luo, Changfu Zhao, Jinfeng Pang, Xianbin Ning, Zhaoyi Ding, Chuang Li
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa Políticas de preços e assinaturas Begell House Contato Language English 中文 Русский Português German French Spain