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Journal of Environmental Pathology, Toxicology and Oncology
Главный редактор: Qian Peng (open in a new tab)

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ISSN Печать: 0731-8898

ISSN Онлайн: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Radiolabeling of Cisplatin and Its Biodistribution in an Experimental Model of Lung Carcinogenesis

Том 33, Выпуск 1, 2014, pp. 11-17
DOI: 10.1615/JEnvironPatholToxicolOncol.2014008013
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Краткое описание

This study optimized the radiolabeling of cisplatin with technetium-99m (99mTc) and evaluated its biodistribution in an experimental model of lung carcinogenesis. The percentage labeling of cisplatin with 99mTc was assessed using an ascending chromatographic technique. For biodistribution studies, male rats were divided into 2 groups. The control group received normal saline intratracheally, whereas the treatment group received intratracheal administration of carcinogen 7,12-dimethylbenz(a)anthracene (DMBA) at a dose of 20 mg/kg body weight. The resulting radiopharmaceutical (99mTc-cisplatin) showed 98% labeling efficiency and was found to be stable for up to 6 hours both in both serum and saline under normal conditions. The blood clearance of the 99mTc-cisplatin followed a biphasic release pattern whereby a fast-release phase was observed at 35 seconds and a slow-release phase was observed after 30 minutes of drug administration. The biodistribution studies of control and treated animals revealed high uptake of 99mTc-cisplatin by the liver and slow excretion via the kidneys. However, a time-dependent increase in the lung-to-muscle specific uptake ratio was observed in DMBA-treated rats. The study concluded that 99mTc-cisplatin possesses selectivity toward cancerous lung tissue and can be explored further for its diagnostic potential in the detection of lung cancer and the evaluation of treatment response.

Ключевые слова: 99mTc-Cisplatin, biodistribution, lung carcinogenesis
ЦИТИРОВАНО В
  1. Leal A. S., Marzano I. M., Pereira-Maia E. C., Jacimovic R., Investigation of the potential antitumor radioactive complex of platinum(II) with tetracycline, Journal of Radioanalytical and Nuclear Chemistry, 309, 1, 2016. Crossref

  2. Kumar Kulvinder, Ghanghas Preety, Sanyal S. N., Chemopreventive action of Imatinib, a tyrosine kinase inhibitor in the regulation of angiogenesis and apoptosis in rat model of lung cancer, Molecular and Cellular Biochemistry, 447, 1-2, 2018. Crossref

  3. Sana Ayesha, Rasheed Rashid, Rafique Asma, Khaliq Tooba, Jabeen Nazish, Murtaza Ghulam, Gynaecological Cancer Diagnostics: 99mTc-Cisplatin Complex as a Future Approach for Early, Prompt and Efficient Diagnosis of Gynaecological Cancer, Current Medical Imaging Formerly Current Medical Imaging Reviews, 15, 7, 2019. Crossref

  4. Bussolotti Giovana, Krstic Dragana , Nikezic Dragoslav, Soares Leal Alexandre, Melo Mendes Bruno, Zivkovic Milena , Internal computational dosimetry of natural cisplatin activated in neutron flux, Brazilian Journal of Radiation Sciences, 10, 2A, 2022. Crossref

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