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Journal of Environmental Pathology, Toxicology and Oncology
Главный редактор: Qian Peng (open in a new tab)

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ISSN Печать: 0731-8898

ISSN Онлайн: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Black Tea Extract: A Supplementary Antioxidant in Radiation-Induced Damage to DNA and Normal Lymphocytes

Том 31, Выпуск 2, 2012, pp. 155-166
DOI: 10.1615/JEnvironPatholToxicolOncol.v31.i2.70
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Краткое описание

Myriad research has contributed significantly toward the understanding and identification of health benefits stemming from tea polyphenols and many other naturally occurring flavonoids present in fruits and vegetables. These flavonoids are known to mitigate reactive oxygen species−induced damage by scavenging them. In this study, hot-water black tea extract rich in flavonoids is evaluated as a supplementary antioxidant. The antioxidant efficacy of black tea extract was investigated by evaluating radioprotection conferred to pBR322 DNA, calf thymus DNA, and normal lymphocytes during gamma irradiation. The protection was measured by gel electrophoresis, fluorimetric study, cell viability assay, cytokinesis-blocked micronuclei assay, and comet assay. The 2,2-diphenyl-1-picrylhydrazyl scavenging ability of the tea extract used increased in a dose-dependent manner (IC50: 182.45 µg/mL). Positive correlation of radioprotection with antioxidant activity of black tea extract was observed in all systems. Maximum protection against radiation-induced damage was observed in pBR322 DNA and calf thymus DNA at ≥200 µg/mL of black tea extract. At a dose of black tea extract as low as 5 µg/mL, efficient radioprotection was observed in normal lymphocytes, which is encouraging and can be tested in the future as a natural antioxidant supplement during radiotherapy.

ЦИТИРОВАНО В
  1. Gandhi Nitin Motilal, Baicalein protects mice against radiation-induced DNA damages and genotoxicity, Molecular and Cellular Biochemistry, 379, 1-2, 2013. Crossref

  2. Pal Sandip, Saha Chabita, Dey Subrata Kumar, Studies on black tea (Camellia sinensis) extract as a potential antioxidant and a probable radioprotector, Radiation and Environmental Biophysics, 52, 2, 2013. Crossref

  3. Pal Sandip, Saha Chabita, A review on structure–affinity relationship of dietary flavonoids with serum albumins, Journal of Biomolecular Structure and Dynamics, 32, 7, 2014. Crossref

  4. Chen Liming, Liu Yinghui, Dong Liangliang, Chu Xiaoxia, Edaravone protects human peripheral blood lymphocytes from γ-irradiation-induced apoptosis and DNA damage, Cell Stress and Chaperones, 20, 2, 2015. Crossref

  5. Ghosh Debjani, Dey Subrata Kumar, Saha Chabita, Antagonistic effects of black tea against gamma radiation-induced oxidative damage to normal lymphocytes in comparison with cancerous K562 cells, Radiation and Environmental Biophysics, 53, 4, 2014. Crossref

  6. Singh Brahma N., Prateeksha , Rawat A. K. S., Bhagat R. M., Singh B. R., Black tea: Phytochemicals, cancer chemoprevention, and clinical studies, Critical Reviews in Food Science and Nutrition, 57, 7, 2017. Crossref

  7. Vasin Mikhail V., Bioflavonoids as Important Component of Biological Protection from Ionizing Radiation, Food and Nutrition Sciences, 05, 05, 2014. Crossref

  8. Bi Yanliang, Yang Chuntao, Diao Qiyu, Tu Yan, Effects of dietary supplementation with two alternatives to antibiotics on intestinal microbiota of preweaned calves challenged with Escherichia coli K99, Scientific Reports, 7, 1, 2017. Crossref

  9. Mondal Tanmoy, Pal Sandip, Dey Subrata Kumar, Quercetin Mediated Inhibition of Hydrogen Peroxide-induced Genomic DNA Damage and Toxicity, Journal of Biologically Active Products from Nature, 7, 3, 2017. Crossref

  10. JEŽOVIČOVÁ MIRIAM, KOŇARIKOVÁ KATARÍNA, ĎURAČKOVÁ ZDEŇKA, KERESTEŠ JÁN, KRÁLIK GABRIEL, ŽITŇANOVÁ INGRID, Protective effects of black tea extract against oxidative DNA damage in human lymphocytes, Molecular Medicine Reports, 13, 2, 2016. Crossref

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  12. Long Wei, Zhang Guanghui, Dong Yinping, Li Deguan, Dark tea extract mitigates hematopoietic radiation injury with antioxidative activity, Journal of Radiation Research, 59, 4, 2018. Crossref

  13. Ganguly Durba, Chandra Santra Ramesh, Mazumdar Swagata, Saha Abhijit, Karmakar Parimal, Das Saurabh, Radioprotection of thymine and calf thymus DNA by an azo compound: mechanism of action followed by DPPH radical quenching & ROS depletion in WI 38 lung fibroblast cells, Heliyon, 6, 5, 2020. Crossref

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