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Journal of Environmental Pathology, Toxicology and Oncology
Главный редактор: Qian Peng (open in a new tab)

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ISSN Печать: 0731-8898

ISSN Онлайн: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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The Influence of Gingerol Treatment on Aluminum Toxicity in Rats

Том 34, Выпуск 1, 2015, pp. 11-21
DOI: 10.1615/JEnvironPatholToxicolOncol.2015011778
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Краткое описание

Background: Ginger is widely used as a medicine in the Ayurvedic system. It contains the active compound gingerol, which scavenges free radicals. Prolonged intake of aluminum (Al) in drinking water and from other sources may lead to neurological, renal, and hepatic dysfunction. Objective: The present study was designed to evaluate the protective effect of gingerol, an active principal of ginger against aluminum as Al (NO3)3 -induced toxicity in rats. Methods: Al (NO3)3 at 32.5 mg/kg body weight was administered to female albino rats intraperitoneally once only, followed by treatment with gingerol at 25, 50, and 100 mg/kg p.o. for 3 consecutive days beginning 24 h after Al exposure. Animals of all of the groups were sacrificed after 48 h of the last gingerol treatment for experimental observations. Results: Significant elevations were observed in serum tranaminases, cholesterol, triglyceride, creatinine, urea, and blood δ-aminolevulinic acid dehydratase (ALAD) after Al exposure. In liver, kidney, and brain tissues, the thiobarbituric acid reactive substances (TBARS) level and total and esterified cholesterol were significantly increased, whereas glutathione (GSH), acetyl cholinesterase (AChE), and δ-aminolevulinic acid synthetase (ALAS) were significantly decreased. Treatment of gingerol for 3 days surprisingly reversed almost all of the biochemical variables toward control levels in a significant manner. Conclusion: Treatment with gingerol (50 mg/kg body weight) was most effective in coping with aluminum-induced toxicity in rats. The antioxidant activity of gingerol might be due not only to the radical scavenging activity of antioxidants but also to the affinity of these antioxidants to the substrates.

Ключевые слова: acetyl cholinesterase, brain, kidney, liver, oxidative stress
ЦИТИРОВАНО В
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  2. Yu Leilei, Zhai Qixiao, Yin Ruijie, Li Peng, Tian Fengwei, Liu Xiaoming, Zhao Jianxin, Gong Jianhua, Zhang Hao, Chen Wei, Lactobacillus plantarum CCFM639 Alleviate Trace Element Imbalance-Related Oxidative Stress in Liver and Kidney of Chronic Aluminum Exposure Mice, Biological Trace Element Research, 176, 2, 2017. Crossref

  3. Litbarg Natalia O., Chronic Kidney Disease, in Integrative Medicine, 2018. Crossref

  4. Yu Leilei, Zhai Qixiao, Tian Fengwei, Liu Xiaoming, Wang Gang, Zhao Jianxin, Zhang Hao, Narbad Arjan, Chen Wei, Lactobacillus plantarum CCFM639 can prevent aluminium-induced neural injuries and abnormal behaviour in mice, Journal of Functional Foods, 30, 2017. Crossref

  5. Tian Fengwei, Yu Leilei, Zhai Qixiao, Xiao Yue, Shi Ying, Jiang Jinchi, Liu Xiaoming, Zhao Jianxin, Zhang Hao, Chen Wei, Hu Yi, The therapeutic protection of a living and dead Lactobacillus strain against aluminum-induced brain and liver injuries in C57BL/6 mice, PLOS ONE, 12, 4, 2017. Crossref

  6. Joshi Deepmala, Srivastav Sunil Kumar, Belemkar Sateesh, Dixit Vaibhav A., Zingiber officinale and 6-gingerol alleviate liver and kidney dysfunctions and oxidative stress induced by mercuric chloride in male rats: A protective approach, Biomedicine & Pharmacotherapy, 91, 2017. Crossref

  7. Alsherbiny Muhammad A., Abd-Elsalam Wessam H., El badawy Shymaa A., Taher Ehab, Fares Mohamed, Torres Allan, Chang Dennis, Li Chun Guang, Ameliorative and protective effects of ginger and its main constituents against natural, chemical and radiation-induced toxicities: A comprehensive review, Food and Chemical Toxicology, 123, 2019. Crossref

  8. Ali Noura M., Mahmoud Amr A. A., Mahmoud Mona F., El Fayoumi Hassan M., Glycyrrhizic acid and silymarin alleviate the neurotoxic effects of aluminum in rats challenged with fructose-induced insulin resistance: possible role of toll-like receptor 4 pathway, Drug and Chemical Toxicology, 42, 2, 2019. Crossref

  9. Hosseini Seyed Mohammad, Hejazian Leila Beigom, Amani Reza, Siahchehreh Badeli Negin, Geraniol attenuates oxidative stress, bioaccumulation, serological and histopathological changes during aluminum chloride-hepatopancreatic toxicity in male Wistar rats, Environmental Science and Pollution Research, 27, 16, 2020. Crossref

  10. Yahyazadeh Roghayeh, Baradaran Rahimi Vafa, Yahyazadeh Ahmad, Mohajeri Seyed Ahmad, Askari Vahid Reza, Promising effects of gingerol against toxins: A review article, BioFactors, 47, 6, 2021. Crossref

  11. Taghizadeh Mohsen, Farzin Narjes, Taheri Sara, Mahlouji Mahnaz, Akbari Hossein, Karamali Fatemeh, Asemi Zatollah, The Effect of Dietary Supplements Containing Green Tea, Capsaicin and Ginger Extracts on Weight Loss and Metabolic Profiles in Overweight Women: A Randomized Double-Blind Placebo-Controlled Clinical Trial, Annals of Nutrition and Metabolism, 70, 4, 2017. Crossref

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