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Journal of Environmental Pathology, Toxicology and Oncology
Главный редактор: Qian Peng (open in a new tab)

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ISSN Печать: 0731-8898

ISSN Онлайн: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Suppressive Effect of Natural Sesquiterpenoids on Inducible Cyclooxygenase (COX-2) and Nitric Oxide Synthase (iNOS) Activity in Mouse Macrophage Cells

Том 21, Выпуск 2, 2002, 8 pages
DOI: 10.1615/JEnvironPatholToxicolOncol.v21.i2.70
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Краткое описание

Prostaglandins and nitric oxide produced by inducible cyclooygenase (COX-2) and nitric oxide synthase (iNOS), respectively, have been implicated as important mediators in the processes of inflammation and carcinogenesis. These potential COX-2 and iNOS inhibitors have been considered as antiinflammatory and cancer chemopreventive agents. In this study, we investigated the effect of natural Sesquiterpenoids isolated from plants of the Zingiberaceae family on the activities of COX-2 and iNOS in cultured lipopolysaccharide (LPS)-activated mouse macrophage cell RAW 264.7 to discover new lead compounds as COX-2 or iNOS inhibitors. Xanthorrhizol, a sesquiterpenoid, isolated from the rhizome of Curcuma xanthorrhiza Roxb. (Zingiberaceae), exhibited a potent inhibition of COX-2 (IC50 = 0.2 g/mL) and iNOS activity (IC50 = 1.0 g/mL) in the assay system of prostaglandin E2 (PGE2) accumulation and nitric oxide production, respectively. Western blot analyses revealed that the inhibitory potential of xanthorrhizol on the COX-2 activity coincided well with the suppression of COX-2 protein expression in LPS-induced macrophages. In addition, Sesquiterpenoids b-turmerone and ar-turmerone isolated from the rhizome of Curcuma zedoaria Roscoe (Zingiberaceae) also showed a potent inhibitory activity of COX-2 (b-turmerone, IC50 = 1.6 mg/mL; ar-turmerone, IC50 = 5.2 mg/mL) and iNOS (b-turmerone, IC50 = 4.6 mg/mL; ar-turmerone, IC50 = 3.2 mg/mL). These results suggest that natural sesquiterpenoids from C. xanthorrhiza and C. zedoariu might be lead candidates for further developing COX-2 or iNOS inhibitors possessing cancer chemopreventive or anti-inflammatory properties.

ЦИТИРОВАНО В
  1. Li Qiang-Ming, Luo Jian-Guang, Wang Xiao-Bing, Yang Ming-Hua, Kong Ling-Yi, Sesquiterpenes from the rhizomes of Alpinia japonica and their inhibitory effects on nitric oxide production, Fitoterapia, 86, 2013. Crossref

  2. References, in Essential Oil Safety, 2014. Crossref

  3. Tisserand Robert, Young Rodney, Constituent profiles, in Essential Oil Safety, 2014. Crossref

  4. Cho Jae Young, Hwang Jae-Kwan, Chun Hyang Sook, Xanthorrhizol attenuates dextran sulfate sodium-induced colitis via the modulation of the expression of inflammatory genes in mice, Life Sciences, 88, 19-20, 2011. Crossref

  5. Uhlenhut Klaus, Högger Petra, Facilitated cellular uptake and suppression of inducible nitric oxide synthase by a metabolite of maritime pine bark extract (Pycnogenol), Free Radical Biology and Medicine, 53, 2, 2012. Crossref

  6. Oh Hyun-In, Shim Jae-Seok, Gwon Song-Hui, Kwon Ho-Jeong, Hwang Jae-Kwan, The effect of xanthorrhizol on the expression of matrix metalloproteinase-1 and type-I procollagen in ultraviolet-irradiated human skin fibroblasts, Phytotherapy Research, 23, 9, 2009. Crossref

  7. Mohammadi Azam, Mohammad-Alizadeh-Charandabi Sakineh, Mirghafourvand Mojgan, Javadzadeh Yousef, Fardiazar Zahra, Effati-Daryani Fatemeh, Effects of cinnamon on perineal pain and healing of episiotomy: a randomized placebo-controlled trial, Journal of Integrative Medicine, 12, 4, 2014. Crossref

  8. Meragelman Tamara L., Renteria Beatriz Salido, Silva Gloria L., Sotomayor Claudia, Gil Roberto R., Modified secoiridoid from Acicarpha tribuloides and inhibition of nitric oxide production in LPS-activated macrophages, Phytochemistry, 67, 14, 2006. Crossref

  9. Lantz R.C., Chen G.J., Solyom A.M., Jolad S.D., Timmermann B.N., The effect of turmeric extracts on inflammatory mediator production, Phytomedicine, 12, 6-7, 2005. Crossref

  10. Cerella Claudia, Sobolewski Cyril, Dicato Mario, Diederich Marc, Targeting COX-2 expression by natural compounds: A promising alternative strategy to synthetic COX-2 inhibitors for cancer chemoprevention and therapy, Biochemical Pharmacology, 80, 12, 2010. Crossref

  11. Jantaratnotai Nattinee, Utaisincharoen Pongsak, Piyachaturawat Pawinee, Chongthammakun Sukumal, Sanvarinda Yupin, Inhibitory effect of Curcuma comosa on NO production and cytokine expression in LPS-activated microglia, Life Sciences, 78, 6, 2006. Crossref

  12. Park Ji-Young, Cho Hye-Yeon, Kim Jong-Kyung, Noh Kyung-Hee, Yang Jeong-Rye, Ahn Jeong-Mi, Lee Mi-Ok, Song Young-Sun, Chlorella dichloromethane extract ameliorates NO production and iNOS expression through the down-regulation of NFκB activity mediated by suppressed oxidative stress in RAW 264.7 macrophages, Clinica Chimica Acta, 351, 1-2, 2005. Crossref

  13. Choi Min-Ah, Kim Seong Hwan, Chung Won-Yoon, Hwang Jae-Kwan, Park Kwang-Kyun, Xanthorrhizol, a natural sesquiterpenoid from Curcuma xanthorrhiza, has an anti-metastatic potential in experimental mouse lung metastasis model, Biochemical and Biophysical Research Communications, 326, 1, 2004. Crossref

  14. Hanprasertpong Nutthiya, Pantong Ampai, Sangdee Chaichan, Kunanusorn Puongtip, Kasitanon Nuntana, Lhieochaiphant Sorasak, Teekachunhatean Supanimit, Cryptolepis buchanani oil formulation versus indomethacin solution in topical therapy for osteoarthritis of the knee: A randomized controlled trial, Journal of Herbal Medicine, 7, 2017. Crossref

  15. Sun Wen, Wang Sheng, Zhao Wenwen, Wu Chuanhong, Guo Shuhui, Gao Hongwei, Tao Hongxun, Lu Jinjian, Wang Yitao, Chen Xiuping, Chemical constituents and biological research on plants in the genusCurcuma, Critical Reviews in Food Science and Nutrition, 57, 7, 2017. Crossref

  16. LI YAN, SHI XUE, ZHANG JINGWEN, ZHANG XIANG, MARTIN ROBERT C.G., Hepatic protection and anticancer activity of curcuma: A potential chemopreventive strategy against hepatocellular carcinoma, International Journal of Oncology, 44, 2, 2014. Crossref

  17. Aati Hanan, El-Gamal Ali, Kayser Oliver, Chemical composition and biological activity of the essential oil from the root of Jatropha pelargoniifolia Courb. native to Saudi Arabia, Saudi Pharmaceutical Journal, 27, 1, 2019. Crossref

  18. de Melo Gessilda Alcantara Nogueira, Grespan Renata, Fonseca Jefferson Pitelli, Farinha Thiago Oliveira, Silva Expedito Leite, Romero Adriano Lopes, Bersani-Amado Ciomar A., Cuman Roberto Kenji Nakamura, Rosmarinus officinalis L. Essential Oil Inhibits In Vivo and In Vitro Leukocyte Migration, Journal of Medicinal Food, 14, 9, 2011. Crossref

  19. Dosoky Noura, Setzer William, Chemical Composition and Biological Activities of Essential Oils of Curcuma Species, Nutrients, 10, 9, 2018. Crossref

  20. Kawasaki Kengo, Okuda-Hanafusa Chinatsu, Aoyagi Morihiro, Taoka Koichi, Yamamoto Norio, Muroyama Koutarou, Murosaki Shinji, Yamamoto Yoshihiro, Inhibitory effect of the compounds from the water extract of Curcuma longa on the production of PGE2 and NO in a macrophage cell line stimulated by LPS, Bioscience, Biotechnology, and Biochemistry, 82, 12, 2018. Crossref

  21. Meiyanto Edy, Larasati Yonika Arum, The Chemopreventive Activity of Indonesia Medicinal Plants Targeting on Hallmarks of Cancer, Advanced Pharmaceutical Bulletin, 9, 2, 2019. Crossref

  22. Kang You-Jin, Park Kwang-Kyun, Chung Won-Yoon, Hwang Jae-Kwan, Lee Sang Kook, Xanthorrhizol, a Natural Sesquiterpenoid, Induces Apoptosis and Growth Arrest in HCT116 Human Colon Cancer Cells, Journal of Pharmacological Sciences, 111, 3, 2009. Crossref

  23. Matsuda Hisashi, Nakamura Seikou, Yoshikawa Masayuki, Degranulation Inhibitors from Medicinal Plants in Antigen-Stimulated Rat Basophilic Leukemia (RBL-2H3) Cells, CHEMICAL & PHARMACEUTICAL BULLETIN, 64, 2, 2016. Crossref

  24. Ping Zang, Jun Xue, Yan Wang, Jun Zhang, WITHDRAWN: Anti-cancer properties of specific Chinese herbal medicines for hepatocellular carcinoma treatment, European Journal of Integrative Medicine, 2020. Crossref

  25. Kim Minwoo, Cho Hee, Ahn Dae-Gyun, Jung Hae-Gwang, Seo Han Young, Kim Ji-Su, Lee Youn-Jung, Choi Jun Yong, Park In Ho, Shin Jeon-Soo, Kim Seong-Jun, Oh Jong-Won, In Vitro Replication Inhibitory Activity of Xanthorrhizol against Severe Acute Respiratory Syndrome Coronavirus 2, Biomedicines, 9, 11, 2021. Crossref

  26. Shahid Muhammad, Azfaralariff Ahmad, Law Douglas, Najm Ahmed Abdulkareem, Sanusi Siti Aisyah, Lim Seng Joe, Cheah Yew Hoong, Fazry Shazrul, Comprehensive computational target fishing approach to identify Xanthorrhizol putative targets, Scientific Reports, 11, 1, 2021. Crossref

  27. Abdel-Hamid Nabil M., Abass Shimaa A., Mohamed Ahmed A., Muneam Hamid Daniah, Herbal management of hepatocellular carcinoma through cutting the pathways of the common risk factors, Biomedicine & Pharmacotherapy, 107, 2018. Crossref

  28. Rahmat Endang, Lee Jun, Kang Youngmin, Zarrelli Armando, Javanese Turmeric (Curcuma xanthorrhiza Roxb.): Ethnobotany, Phytochemistry, Biotechnology, and Pharmacological Activities, Evidence-Based Complementary and Alternative Medicine, 2021, 2021. Crossref

  29. Mandlik Deepa S., Mandlik Satish K., Herbal and Natural Dietary Products: Upcoming Therapeutic Approach for Prevention and Treatment of Hepatocellular Carcinoma, Nutrition and Cancer, 73, 11-12, 2021. Crossref

  30. Prieto Jose M., Schinella Guillermo R., Anti-Inflammatory and Antioxidant Chinese Herbal Medicines: Links between Traditional Characters and the Skin Lipoperoxidation “Western” Model, Antioxidants, 11, 4, 2022. Crossref

  31. Bian Xiang-xiang, Zhao Xuan, Liu Shan-shan, Wu Lan, Yin Xiu-wen, Shen Chuan-pu, Sesquiterpene dimers from Chloranthus fortunei and their protection activity against acute lung injury, Fitoterapia, 159, 2022. Crossref

  32. Simamora Adelina, Timotius Kris Herawan, Yerer Mukerrem Betul, Setiawan Heri, Mun'im Abdul, Xanthorrhizol, a potential anticancer agent, from Curcuma xanthorrhiza Roxb, Phytomedicine, 105, 2022. Crossref

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