Выходит 4 номеров в год
ISSN Печать: 0731-8898
ISSN Онлайн: 2162-6537
Indexed in
Effects of Yakuchinone A and Yakuchinone В on the Phorbol Ester-Induced Expression of COX-2 and iNOS and Activation of NF-kB in Mouse Skin
Краткое описание
Certain medicinal plants contain anti-inflammatory and antioxidative substances that can exert chemopreventive effects. Our previous studies have demonstrated that the methanol extract of Alpinia oxyphylla Miquel (Zingiberaceae) inhibits tumor promotion in mouse skin. Two major diarylheptanoids named yakuchinone A (l-[4'-hydroxy-3'-methoxyphenyl]-7-phenyl-3-heptanone) and yakuchinone В (l-[4'-hydroxy-3'-methoxyphenyl]-7-phenylhept-l-en-3-one) have been isolated from this medicinal plant. Both compounds have strong inhibitory effects on the synthesis of prostaglandins and leukotrienes in vitro. In the present work, we show that both yakuchinone A and yakuchinone В inhibit the expression of cyclooxygenase-2 (COX-2) and of inducible nitric oxide synthase (iNOS) as well as the expression of tumor necrosis factor (TNF)-a mRNA in mouse skin treated with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Topical application on mouse skin of these diarylheptanoids also attenuated the TPA-induced DNA binding activity of the ubiquitous eukaryotic transcription factor NF-kB that plays a crucial role in regulating the expression of the aforementioned proinflammatory enzymes and cytokines in response to a wide variety of external stimuli. These findings suggest that diarylheptanoids contained in Alpinia oxyphylla down-regulate COX-2 and iNOS expression through suppression of NF-kB activation in the TPA-treated mouse skin.
-
Afaq Farrukh, Saleem Mohammad, Krueger Christian G., Reed Jess D., Mukhtar Hasan, Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-?B pathways and inhibits skin tumorigenesis in CD-1 mice, International Journal of Cancer, 113, 3, 2005. Crossref
-
Zhang Guodong, Nitteranon Viriya, Chan Lok Yan, Parkin Kirk L., Glutathione conjugation attenuates biological activities of 6-dehydroshogaol from ginger, Food Chemistry, 140, 1-2, 2013. Crossref
-
Sarfaraz S., Siddiqui I. A., Syed D. N., Afaq F., Mukhtar H., Guggulsterone modulates MAPK and NF- B pathways and inhibits skin tumorigenesis in SENCAR mice, Carcinogenesis, 29, 10, 2008. Crossref
-
Chen Feng, Li Hai-Long, Tan Yin-Feng, Li Yong-Hui, Lai Wei-Yong, Guan Wei-Wei, Zhang Jun-Qing, Zhao Yuan-Sheng, Qin Zhen-Miao, Identification of known chemicals and their metabolites from Alpinia oxyphylla fruit extract in rat plasma using liquid chromatography/tandem mass spectrometry (LC–MS/MS) with selected reaction monitoring, Journal of Pharmaceutical and Biomedical Analysis, 97, 2014. Crossref
-
Mishra Sakshi, Tripathi Anurag, Chaudhari Bhushan P., Dwivedi Premendra D., Pandey Haushila P., Das Mukul, Deoxynivalenol induced mouse skin cell proliferation and inflammation via MAPK pathway, Toxicology and Applied Pharmacology, 279, 2, 2014. Crossref
-
Chen Feng, Li Hai-Long, Tan Yin-Feng, Guan Wei-Wei, Zhang Jun-Qing, Li Yong-Hui, Zhao Yuan-Sheng, Qin Zhen-Miao, Different Accumulation Profiles of Multiple Components Between Pericarp and Seed of Alpinia oxyphylla Capsular Fruit as Determined by UFLC-MS/MS, Molecules, 19, 4, 2014. Crossref
-
Zhang Qiao, Cui Can, Chen Cong-Qin, Hu Xiao-Long, Liu Ya-Hui, Fan Yan-Hua, Meng Wei-Hong, Zhao Qing-Chun, Anti-proliferative and pro-apoptotic activities of Alpinia oxyphylla on HepG2 cells through ROS-mediated signaling pathway, Journal of Ethnopharmacology, 169, 2015. Crossref
-
Fang Jia-You, Leu Yann-Lii, Hwang Tsong-Long, Cheng Hsiao-Chin, Hung Chi-Feng, Development of sesquiterpenes from Alpinia oxyphylla as novel skin permeation enhancers, European Journal of Pharmaceutical Sciences, 19, 4, 2003. Crossref
-
Kundu Joydeb Kumar, Surh Young-Joon, Breaking the relay in deregulated cellular signal transduction as a rationale for chemoprevention with anti-inflammatory phytochemicals, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 591, 1-2, 2005. Crossref
-
Kao Erl-Shyh, Wang Chau-Jong, Lin Wea-Lung, Chu Chia-Yih, Tseng Tsui-Hwa, Effects of polyphenols derived from fruit of Crataegus pinnatifida on cell transformation, dermal edema and skin tumor formation by phorbol ester application, Food and Chemical Toxicology, 45, 10, 2007. Crossref
-
Afaq Farrukh, Saleem Mohammad, Aziz Moammir Hasan, Mukhtar Hasan, Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion markers in CD-1 mouse skin by oleandrin, Toxicology and Applied Pharmacology, 195, 3, 2004. Crossref
-
He Zhi-Heng, Ge Wei, Yue Grace Gar-Lee, Lau Clara Bik-San, He Ming-Fang, But Paul Pui-Hay, Anti-angiogenic effects of the fruit of Alpinia oxyphylla, Journal of Ethnopharmacology, 132, 2, 2010. Crossref
-
Lee Chung-Jo, Shim Ki-Shuk, Ma Jin Yeul, Artemisia capillaris Alleviates Bone Loss by Stimulating Osteoblast Mineralization and Suppressing Osteoclast Differentiation and Bone Resorption, The American Journal of Chinese Medicine, 44, 08, 2016. Crossref
-
Zhang Qiao, Zheng Yunliang, Hu Xingjiang, Hu Xiaolong, Lv Wenwen, Lv Duo, Chen Jinjin, Wu Minglan, Song Qichao, Shentu Jianzhong, Ethnopharmacological uses, phytochemistry, biological activities, and therapeutic applications of Alpinia oxyphylla Miquel: A review, Journal of Ethnopharmacology, 224, 2018. Crossref
-
Ko Kiwon, Hong In Kee, Cho Hyun-Jong, Kim Young Ho, Yang Heejung, Simultaneous Determination of Four Compounds from Artemisia capillaris using High Performance Liquid Chromatography-Ultraviolet Detector (HPLC-UVD) and Their Quantitative Study in Artemisia Genus, Natural Product Sciences, 24, 2, 2018. Crossref
-
Lee Yun Mi, Son Eunjung, Kim Seung-Hyung, Kim Dong-Seon, Effect of Alpinia oxyphylla extract in vitro and in a monosodium iodoacetate-induced osteoarthritis rat model, Phytomedicine, 65, 2019. Crossref
-
Chen Feng, Li Hai-Long, Tan Yin-Feng, Guan Wei-Wei, Li Yong-Hui, Zhang Jun-Qing, Validated method to measure yakuchinone A in plasma by LC-MS/MS and its application to a pharmacokinetic study in rats, Chemistry Central Journal, 8, 1, 2014. Crossref
-
Huang Kuo-Kuei, Lin Meng-Nan, Hsu Yi-Ling, Lu I-Huang, Pan I-Hong, Yang Jia-Ling, Alpinia oxyphyllaFruit Extract Ameliorates Experimental Autoimmune Encephalomyelitis through the Regulation of Th1/Th17 Cells, Evidence-Based Complementary and Alternative Medicine, 2019, 2019. Crossref
-
Chen Feng, Li Hai-long, Li Yong-Hui, Tan Yin-Feng, Zhang Jun-Qing, Quantitative analysis of the major constituents in Chinese medicinal preparation SuoQuan formulae by ultra fast high performance liquid chromatography/quadrupole tandem mass spectrometry, Chemistry Central Journal, 7, 1, 2013. Crossref
-
Kim Min Young, Hwang Hyung Seo, Improving effect of psoriasis dermatitis by yakuchinone A in the TNF-α stimulated HaCaT cells, Journal of Applied Biological Chemistry, 63, 1, 2020. Crossref
-
Yu Su Hyun, Kim Hyun Jin, Jeon Se Yeong, Kim Mi Ran, Lee Bo Su, Lee Jeong Jun, Kim Dong-Seon, Lee Young Chul, Anti-inflammatory and anti-nociceptive activities of Alpinia Oxyphylla Miquel extracts in animal models, Journal of Ethnopharmacology, 260, 2020. Crossref
-
Ullah Md. Asad, Johora Fatema Tuz, Sarkar Bishajit, Araf Yusha, Rahman MD. Hasanur, Curcumin analogs as the inhibitors of TLR4 pathway in inflammation and their drug like potentialities: a computer-based study, Journal of Receptors and Signal Transduction, 40, 4, 2020. Crossref
-
Pan Yanni, Wang Hong, Tan Fang, Yi Ruokun, Li Wenfeng, Long Xingyao, Mu Jianfei, Zhao Xin, Lactobacillus plantarum KFY02 enhances the prevention of CCl4-induced liver injury by transforming geniposide into genipin to increase the antioxidant capacity of mice, Journal of Functional Foods, 73, 2020. Crossref
-
Li Yong-Hui, Chen Feng, Wang Jun-fang, Wang Yong, Zhang Jun-Qing, Guo Tao, Analysis of nine compounds from Alpinia oxyphyllafruit at different harvest time using UFLC-MS/MS and an extraction method optimized by orthogonal design, Chemistry Central Journal, 7, 1, 2013. Crossref
-
Lin Rong-Jyh, Yen Chuan-Min, Chou Tzung-Han, Chiang Feng-Yu, Wang Guey-Horng, Tseng Ya-Ping, Wang Lin, Huang Ting-Wei, Wang Hui-Chuan, Chan Leong-Perng, Ding Hsiou-Yu, Liang Chia-Hua, Antioxidant, anti-adipocyte differentiation, antitumor activity and anthelminticactivities against Anisakis simplex and Hymenolepis nana ofyakuchinone A from Alpinia oxyphylla , BMC Complementary and Alternative Medicine, 13, 1, 2013. Crossref
-
Saleem Mohammad, Afaq Farrukh, Adhami Vaqar Mustafa, Mukhtar Hasan, Lupeol modulates NF-κB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice, Oncogene, 23, 30, 2004. Crossref
-
Shi Xiang, Deng Yu, Kurtz Nicole C., Sun Yue, Xue Mingxing, Wu Xian, Concise and efficient total synthesis of oxyphyllacinol, yakuchione-A and yakuchione-B, Synthetic Communications, 52, 4, 2022. Crossref
-
Ju Hen‐Yi, Huang Kuo‐Chuan, Chen Jiann‐Hwa, Liu Yung‐Chuan, Chang Chieh‐Ming J., Lee Chih‐Chen, Chang Cheng, Shieh Chwen‐Jen, Optimization of the Extraction of Alpinia oxyphylla Essence Oil in Supercritical Carbon Dioxide , Journal of the American Oil Chemists' Society, 87, 9, 2010. Crossref