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ISSN Печать: 0731-8898
ISSN Онлайн: 2162-6537
Indexed in
Radioprotective Role of Selenium after Single-Dose Radioiodine (131I) Exposure to Red Blood Cells of Rats
Краткое описание
The present study elucidated the protective potential of selenium following 131I-induced alterations in rat blood. Forty rats were segregated into 4 groups. Animals in Group I served as normal controls, Group II animals were injected with a single dose of 3.7 Mbq of 131I (carrier free), Group III animals were supplemented with selenium (1 ppm), and Group IV animals were given a combined treatment of selenium and 131I. 131I treatment of rats showed significant increases in total leukocyte counts (TLCs), lymphocytes, and neutrophils (monocytes and eosinophils were not recorded). These were significantly restored upon supplementation of selenium. Lipid peroxidase (LPO), glutathione peroxidase (GSH-PX), reduced glutathione (GSH), superoxide dismutase (SOD), and δ-aminolevulinic acid dehydratase (δ-ALAD) were found to be enhanced following 131I treatment. However, the levels of catalase were found to be decreased. Selenium administration to 131I-treated rats resulted in significant restoration of these enzyme activities. Scanning electron microscope (SEM) studies also revealed various surface deformities in erythrocytes after 131I treatment, which upon supplementation with selenium were significantly restored. In conclusion, selenium may prove to be an effective radioprotector following 131I treatment.
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Sochor Jiri, Pohanka Miroslav, Ruttkay-Nedecky Branislav, Zitka Ondrej, Hynek David, Mares Petr, Zeman Ladislav, Adam Vojtech, Kizek Rene, Effect of selenium in organic and inorganic form on liver, kidney, brain and muscle of Wistar rats, Open Chemistry, 10, 5, 2012. Crossref
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Hazbavi Maryam, Zarei Mansoureh, Nazaralivand Roghayeh, Shahbazian Hojattollah, Cheki Mohsen, Protection from ionizing radiation-induced genotoxicity and apoptosis in rat bone marrow cells by HESA-A: a new herbal-marine compound, Journal of Bioenergetics and Biomembranes, 51, 5, 2019. Crossref