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ISSN Печать: 0731-8898
ISSN Онлайн: 2162-6537
Indexed in
The Quartz Hazard: Effects of Surface and Matrix on Inflammogenic Activity
Краткое описание
Modification of the quartz surface during the history of the particle is a powerful idea in understanding the variability of the quartz hazard. Interactions between quartz and other minerals are likely to occur in sediments, during industrial processing, or in matrix-bound quartz.We discuss new evidence regarding the basis of changes in the quartz surface that relate to changes in its ability to cause inflammation. Different samples of quartz were subjected to various biological assays. Endpoints included instillation of quartz into the tracheobronchial tree and measurement of PMN numbers in bronchoalveolar lavage (BAL) and in lung tissue, levels of the chemokine MIP-2 in BAL,and nuclear translocation of the transcription factor NF-kB in BAL cells. In vitro biological assays included cytotoxicity to epithelial cells, hemolytic activity, and radical activity of the particle surface as measured by electron spin resonance. Treatment of quartz with aluminium lactate impaired its ability to cause PMN recruitment, chemokine release, and NF-kB nuclear translocation in BAL.Workplace quartzes had no proinflammatory activity, which correlated with their ability to cause hemolysis but not their electron spin resonance (ESR) activity. Quartz in a matrix with coalmine dust or fly-ash showed different effects. In fly-ash, the toxicity was masked, but coalmine dusts were more toxic to epithelial cells than pure quartz in vitro; however, after instillation, the long-term inflammation was not related to the in vitro activity. Amelioration of quartz surface activity can occur in workplace samples of quartz and quartz samples whose surface is protected, to the extent that they have very little inflammogenic activity and display an inability to activate key subcellular pathways that lead to inflammation.Quartz from a workplace whose surface has been affected, or in a matrix such as coalmine dust or fly-ash, can have its toxicity modulated. These effects are due to minerals and organic compounds that can both decrease (e.g., aluminium salts) or enhance (e.g., coalmine dust matrix) biological activity and thus may contribute to toxicity in a complex way that is not easily predicted. Iron is a good example.There are reports that it can enhance quartz toxicity, or it may have little role to play in its toxicity, as shown here for almost pure quartz particles. A broad program of further research is needed before we have a sound understanding of the mechanisms of quartz toxicity.
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Wendlandt Richard F., Harrison Wendy J., Vaughan David J., Surface coatings on quartz grains in bentonites and their relevance to human health, Applied Geochemistry, 22, 11, 2007. Crossref
-
Leonard Stephen, Porter Dale, Castranova Vincent, Particles and Cellular Oxidative and Nitrosative Stress, in Particle Toxicology, 2006. Crossref
-
Scully Robert R., Lam Chiu-Wing, James John T., Estimating safe human exposure levels for lunar dust using benchmark dose modeling of data from inhalation studies in rats, Inhalation Toxicology, 25, 14, 2013. Crossref
-
Kodavanti Urmila, Watkinson William, Bioavailability of Particle-Associated Air Pollutants and Relationship to Cardiopulmonary Injury, in Air Pollutants and the Respiratory Tract, Second Edition, 20054265, 2005. Crossref
-
Oxygen/Nitrogen Radicals and Silica-Induced Diseases, in Oxygen/Nitrogen Radicals, 20040763, 2004. Crossref
-
Chauhan V., Breznan D., Thomson E., Karthikeyan S., Vincent R., Effects of ambient air particles on the endothelin system in human pulmonary epithelial cells (A549), Cell Biology and Toxicology, 21, 5-6, 2005. Crossref
-
Okuda-Shimazaki Junko, Takaku Saiko, Kanehira Koki, Sonezaki Shuji, Taniguchi Akiyohshi, Effects of Titanium Dioxide Nanoparticle Aggregate Size on Gene Expression, International Journal of Molecular Sciences, 11, 6, 2010. Crossref
-
Duffin Rodger, Tran Lang, Brown David, Stone Vicki, Donaldson Ken, Proinflammogenic Effects of Low-Toxicity and Metal Nanoparticles In Vivo and In Vitro: Highlighting the Role of Particle Surface Area and Surface Reactivity, Inhalation Toxicology, 19, 10, 2007. Crossref
-
Cokic Stevan M., Ghosh Manosij, Hoet Peter, Godderis Lode, Van Meerbeek Bart, Van Landuyt Kirsten L., Cytotoxic and genotoxic potential of respirable fraction of composite dust on human bronchial cells, Dental Materials, 36, 2, 2020. Crossref
-
Chen Fei, Reactive Oxygen Species in the Activation and Regulation of Intracellular Signaling Events, in Oxygen/Nitrogen Radicals, 20040763, 2004. Crossref
-
Pavan Cristina, Fubini Bice, Unveiling the Variability of “Quartz Hazard” in Light of Recent Toxicological Findings, Chemical Research in Toxicology, 30, 1, 2017. Crossref
-
Liu Guoming, Xu Qianqian, Zhao Jipeng, Nie Wen, Guo Qingkun, Ma Guanguo, Research Status of Pathogenesis of Pneumoconiosis and Dust Control Technology in Mine—A Review, Applied Sciences, 11, 21, 2021. Crossref
-
Sayes Christie M., Marchione Alexander A., Reed Kenneth L., Warheit David B., Comparative Pulmonary Toxicity Assessments of C60 Water Suspensions in Rats: Few Differences in Fullerene Toxicity in Vivo in Contrast to in Vitro Profiles, Nano Letters, 7, 8, 2007. Crossref
-
Albrecht Catrin, Schins Roel P. F., Höhr Doris, Becker Andrea, Shi Tingming, Knaapen Ad M., Borm Paul J. A., Inflammatory Time Course after Quartz Instillation, American Journal of Respiratory Cell and Molecular Biology, 31, 3, 2004. Crossref