Доступ предоставлен для: Guest
Critical Reviews™ in Immunology

Выходит 6 номеров в год

ISSN Печать: 1040-8401

ISSN Онлайн: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

The Proteasome and Its Inhibitors in Immune Regulation and Immune Disorders

Том 26, Выпуск 6, 2006, pp. 487-498
DOI: 10.1615/CritRevImmunol.v26.i6.20
Get accessGet access

Краткое описание

The ubiquitin-proteasome pathway is a well-characterized mechanism deputed to the degradation of intracellular proteins. Proteasomal degradation intervenes in the regulation of numerous cellular functions including signal transduction, apoptosis, cell cycle, and antigen presentation. In vitro and in vivo studies have shown that both normal and malignant cells of the immune system are exquisitely affected by inhibition of proteasome activity. This property is currently exploited in the treatment of multiple myeloma and mantle cell lymphoma, two B-cell malignancies that respond to treatment with the proteasome inhibitor bortezomib. Pharmacological inhibitors of the proteasome also affect function and survival of B and T lymphocytes and of dendritic cells and were shown to reduce autoimmune and inflammatory manifestations in several models of immune-mediated disorders. The present review offers an overview of the mechanisms implicated in the immunomodulatory effects of proteasome inhibitors and discusses prospective future applications for these small molecules in immune and inflammatory diseases.

ЦИТИРОВАНО В
  1. Stübgen Joerg-Patrick, Drug-induced dysimmune demyelinating neuropathies, Journal of the Neurological Sciences, 307, 1-2, 2011. Crossref

  2. Chen Chen, Meng Yan, Wang Lei, Wang Hong-Xia, Tian Cui, Pang Guo-Dong, Li Hui-Hua, Du Jie, Ubiquitin-activating enzyme E1 inhibitor PYR41 attenuates angiotensin II-induced activation of dendritic cells via the IκBa/NF-κB and MKP1/ERK/STAT1 pathways, Immunology, 142, 2, 2014. Crossref

  3. Turchan-Cholewo Jadwiga, Dimayuga Filomena O., Gupta Sunita, Keller Jeffrey N., Knapp Pamela E., Hauser Kurt F., Bruce-Keller Annadora J., Morphine and HIV-Tat increase microglial-free radical production and oxidative stress: possible role in cytokine regulation, Journal of Neurochemistry, 108, 1, 2009. Crossref

  4. Pilecka Iwona, Sadowski Lukasz, Kalaidzidis Yannis, Miaczynska Marta, Recruitment of APPL1 to ubiquitin-rich aggresomes in response to proteasomal impairment, Experimental Cell Research, 317, 8, 2011. Crossref

  5. Finn Jonathan D, Hui Daniel, Downey Harre D, Dunn Danielle, Pien Gary C, Mingozzi Federico, Zhou Shangzhen, High Katherine A, Proteasome Inhibitors Decrease AAV2 Capsid derived Peptide Epitope Presentation on MHC Class I Following Transduction, Molecular Therapy, 18, 1, 2010. Crossref

  6. Vázquez Jesús, García-Jareño Alicia, Mondragón Laura, Rubio-Martinez Jaime, Pérez-Payá Enrique, Albericio Fernando, Conformationally Restricted Hydantoin-Based Peptidomimetics as Inhibitors of Caspase-3 with Basic Groups Allowed at the S3 Enzyme Subsite, ChemMedChem, 3, 6, 2008. Crossref

  7. Ravaglia Sabrina, Corso Alessandro, Piccolo Giovanni, Lozza Alessandro, Alfonsi Enrico, Mangiacavalli Silvia, Varettoni Marzia, Zappasodi Patrizia, Moglia Arrigo, Lazzarino Mario, Costa Alfredo, Immune-mediated neuropathies in myeloma patients treated with bortezomib, Clinical Neurophysiology, 119, 11, 2008. Crossref

  8. Corredor Miriam, Garrido Maria, Bujons Jordi, Orzáez Mar, Pérez‐Payá Enrique, Alfonso Ignacio, Messeguer Angel, Efficient Synthesis of Conformationally Restricted Apoptosis Inhibitors Bearing a Triazole Moiety, Chemistry – A European Journal, 21, 40, 2015. Crossref

  9. Al-Homsi Ahmad-Samer, Cole Kelli, Bogema Marlee, Duffner Ulrich, Williams Stephanie, Mageed Aly, Short Course of Post-Transplantation Cyclophosphamide and Bortezomib for Graft-versus-Host Disease Prevention after Allogeneic Peripheral Blood Stem Cell Transplantation Is Feasible and Yields Favorable Results: A Phase I Study, Biology of Blood and Marrow Transplantation, 21, 7, 2015. Crossref

  10. Lin Amy Erica, Mak Tak W, The role of E3 ligases in autoimmunity and the regulation of autoreactive T cells, Current Opinion in Immunology, 19, 6, 2007. Crossref

  11. Cenci Simone, The Proteasome in Terminal Plasma Cell Differentiation, Seminars in Hematology, 49, 3, 2012. Crossref

  12. Khalturin Konstantin, Anton-Erxleben Friederike, Milde Sabine, Plötz Christine, Wittlieb Jörg, Hemmrich Georg, Bosch Thomas C.G., Transgenic stem cells in Hydra reveal an early evolutionary origin for key elements controlling self-renewal and differentiation, Developmental Biology, 309, 1, 2007. Crossref

  13. Vana P. Geoff, LaPorte Heather M., Wong Yee M., Kennedy Richard H., Gamelli Richard L., Majetschak Matthias, Proteasome Inhibition After Burn Injury, Journal of Burn Care & Research, 37, 4, 2016. Crossref

  14. Toema Bassem, El-Sweilmeen Hamdan, Helmy Tarek, Oculomotor nerve palsy associated with bortezomib in a patient with multiple myeloma: a case report, Journal of Medical Case Reports, 4, 1, 2010. Crossref

  15. Kaplan Gulce Sari, Torcun Ceyda Corek, Grune Tilman, Ozer Nesrin Kartal, Karademir Betul, Proteasome inhibitors in cancer therapy: Treatment regimen and peripheral neuropathy as a side effect, Free Radical Biology and Medicine, 103, 2017. Crossref

  16. Eldor Roy, Abel Roy, Sever Dror, Sadoun Gad, Peled Amnon, Sionov Ronit, Melloul Danielle, Maedler Kathrin, Inhibition of Nuclear Factor-κB Activation in Pancreatic β-Cells Has a Protective Effect on Allogeneic Pancreatic Islet Graft Survival, PLoS ONE, 8, 2, 2013. Crossref

  17. Bosch Thomas C. G., Stem Cells in Immortal Hydra, in Stem Cells, 2008. Crossref

  18. Wang Xin Shelley, Shi Qiuling, Mendoza Tito R., Garcia-Gonzalez Araceli, Chen Ting-Yu, Kamal Mona, Chen Tsun Hsuan, Heijnen Cobi, Orlowski Robert Z., Cleeland Charles S., Minocycline for symptom reduction in patients with multiple myeloma during maintenance therapy: a phase II placebo-controlled randomized trial, Supportive Care in Cancer, 29, 10, 2021. Crossref

  19. Xue Yan, Yun Dong, Esmon Alex, Zou Peng, Zuo Shuai, Yu Yanbao, He Fuchu, Yang Pengyuan, Chen Xian, Proteomic Dissection of Agonist-Specific TLR-Mediated Inflammatory Responses on Macrophages at Subcellular Resolution, Journal of Proteome Research, 7, 8, 2008. Crossref

  20. Mondragón L., Orzáez M., Sanclimens G., Moure A., Armiñán A., Sepúlveda P., Messeguer A., Vicent M. J., Pérez-Payá E., Modulation of Cellular Apoptosis with Apoptotic Protease-Activating Factor 1 (Apaf-1) Inhibitors, Journal of Medicinal Chemistry, 51, 3, 2008. Crossref

  21. Hwang Seungmin, Wu Ting-Ting, Tong Leming M., Kim Kyeong Seon, Martinez-Guzman DeeAnn, Colantonio Arnaud D., Uittenbogaart Christel H., Sun Ren, Persistent Gammaherpesvirus Replication and Dynamic Interaction with the Host In Vivo, Journal of Virology, 82, 24, 2008. Crossref

Статьи, принятые к публикации

Identification of a novel five-gene prognostic model for laryngeal cancer associated with mitophagy using integrated bioinformatics analysis and experimental verification Dong Song, Lun Dong, Mei Wang, Xiaoping Gao Function of steroid receptor coactivators (SRCs) in T cells and cancers: Implications for cancer immunotherapy Wencan Zhang, Xu Cao, Hongmin Wu, Xiancai Zhong, Yun Shi, Zuoming Sun Electroacupuncture Alleviates Ischemic Stroke by Activating the mTOR/SREBP1 Pathway Jiawang Lang, Jianchang Luo, Luodan Wang, Wenbin Xu, Jie Jia, Zhipeng Zhao, Boxu Lang KIAA1429 induces the m6A modification of LINC01106 to enhance the malignancy of lung adenocarcinoma cell via JAK/STAT3 pathway Di Xu, Ziming Wang, Fajiu Li Effect of p-estrogen receptor at serine on its function and breast growth Yuan Liang, Junhui Qin, Tiancheng Ma, Tong Yang, Zhenyu Ke, Ruian Wang Mechanistic Insights into Tanshinone IIA in the Amelioration of Post-Thyroidectomy Hypoparathyroidism Xiaoyu Qian, Lin Li, Liang Chen, Chao Shen, Jian Tang MiRNA let-7d-5p alleviates inflammatory responses by targeting Map3k1 and inactivating ERK/p38 MAPK signaling in microglia Fan Fang, Cheng Chen Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro Kawaljit Kaur, Anahid Jewett The Current and Future States of Natural Killer Cell-Based Immunotherapy in Hepatocellular Carcinoma Tu Nguyen, Po-Chun Chen, Janet Pham, Kawaljit Kaur, Steven Raman, Anahid Jewett, Jason Chiang Phillygenin alleviated arthritis through the inhibition of NLRP3 inflammasome and Ferroptosis by AMPK Jianghui Wang, Shufang Ni, Kai Zheng, Yan Zhao, peihong zhang, Hong Chang The value of systemic immune-inflammation index and T cell subsets in the severity and prognosis of sepsis Hao Zhou Efficacy and Nuances of Precision Molecular Engineering for Hodgkin's Disease to a Gene Therapeutic Approach Muhammad Imran Qadir, Bilal Ahmed, Nadir Hussain Serum interleukin 6 and ferritin levels are the independent risk factors for pneumonia in elderly patients Hao Yuan, Jing Tian, Lu Wen Exploration of diagnostic markers associated with inflammation in chronic kidney disease (CKD) based on WGCNA and machine learning Qianjia Wu, Yang Yang, Chongze Lin Clinical significance of serum CTRP3 level in the prediction of cardiac dysfunction and intestinal mucosal barrier dysfunction in patients with severe acute pancreatitis Qiang Shao, Lin Sun The protective effect and mechanism of mild hypothermia on pig lung injury after cardiopulmonary resuscitation Jinlin Ren, Fangfang Zhu, Dongdong Sang, Mulin Cong, Shujuan Jiang Exploring mechanism of Zilongjin in treating lung adenocarcinoma based on network pharmacology combined with experimental verification Kang Zhang, Xiaoqun Chen Gastric Cancer Immune Subtypes and Prognostic Modeling: Insights from Aging-Related Genes Analysis Jian Shen, Minzhe Li Effects of different doses of dexmedetomidine on the prevention of postoperative sleep disturbance and serum neurotransmitter level in patients under general anesthesia Huifei Lu, Fei He, Ying Huang, Zhongliang Wei Identification of key ubiquitination-related genes and their associated with immune infiltration in osteoarthritis based on mRNA-miRNA network Dalu Yuan, Hailiang Shen, Lina Bai, Menglin Li, Qiujie Ye Diagnostic and Prognostic value of peripheral neutrophil CD64 index in elderly patients with community-acquired pneumonia Yan Li, Jing Zhang, Suhang Wang, Jie Cao Identification of Metabolism-Related Prognostic Biomarkers and Immune Features of Head and Neck Squamous Cell Carcinoma Rongjin Zhou, Junguo Wang Downregulation of miR-503-5p promotes the development of pancreatic cancer via targeting cyclin E2 Fei Li, Ying-pei Ling, Pan Wang, Shi-cheng Gu, Hao Jiang, Jie Zhu
Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции Цены и условия подписки Begell House Контакты Language English 中文 Русский Português German French Spain