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ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472
Indexed in
The Basis of Immunogenicity of Endocrine Allografts
Краткое описание
Two signals are required for optimal T-cell activation: the engagement of the antigen-specific receptor and the provision of a second non–antigen-specific inductive signal, or costimulator (CoS). Regarding allograft immunity, two primary pathways of donor antigen presentation can fulfill this two-signal requirement, resulting in cellular immunity to a transplant: (1) "direct" (donor MHC-restricted) presentation in which the antigen-presenting cells (APCs) resident within the transplant directly activate host T lymphocytes and (2) "indirect" (host MHC-restricted) presentation in which host-derived APCs acquire donor antigens that are then presented to host T lymphocytes. It appears that endocrine allografts, such as pancreatic islets and thyroid, are highly dependent on donor-derived APCs, or "passenger leukocytes," to trigger acute graft rejection. Tissue pretreatment aimed at selectively eliminating APCs within endocrine tissues can result in indefinite allograft survival in immune-competent recipients. Although such results implicate the “direct” pathway as the predominant route of host sensitization, the role of donor APCs in rejection appears to be more complex. Recently, we have found that indirect, CD4 T-cell–dependent reactivity can contribute to islet allograft rejection. However, such indirect recognition nevertheless requires donor-derived APCs as a source of antigen. Thus, whereas the donor-type APC is a critical limiting step for initiating islet allograft rejection, such cells can trigger both direct and indirect forms of immune responses that can result in graft rejection. That is, donor hematopoietic cells, rather than tissue parenchymal cells, probably play a major role in providing antigens that stimulate cellular immunity.
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Alabedalkarim N.M., Bozhok G.A., Legach E.I., Ustichenko V.D., Zubov P.M., Bilyavskaya S.B., Dudetskaya G.V., Bondarenko T.P., Hoffmann M.W., Outcome of adrenal tissue fragments allotransplantation: The impact of cryopreservation, Cryobiology, 65, 3, 2012. Crossref
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Lindeborg Ellinor, Kumagai-Braesch Makiko, Tibell Annika, Christensson Birger, Moller Erna, Biological activity of pig islet-cell reactive IgG antibodies in xenotransplanted diabetic patients, Xenotransplantation, 11, 5, 2004. Crossref
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Siemionow Maria, Klimczak Aleksandra, Tolerance and Future Directions for Composite Tissue Allograft Transplants: Part II, Plastic & Reconstructive Surgery, 123, 1, 2009. Crossref
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Lindeborg Ellinor, Kumagai-Braesch Makiko, Moller Erna, Phenotypic and functional characterization of human T cell clones indirectly activated against adult pig islet cells, Xenotransplantation, 13, 1, 2006. Crossref
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Siemionow M., Klimczak A., Unal S., Agaoglu G., Carnevale K., Hematopoietic Stem Cell Engraftment and Seeding Permits Multi-Lymphoid Chimerism in Vascularized Bone Marrow Transplants, American Journal of Transplantation, 8, 6, 2008. Crossref
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Martins Paulo N. A., Chandraker Anil, Tullius Stefan G., Modifying graft immunogenicity and immune response prior to transplantation: potential clinical applications of donor and graft treatment, Transplant International, 19, 5, 2006. Crossref
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Qureshi Khalid M., Lee Jou, Paget Michelle B., Bailey Clifford J., Curnow S. John, Murray Hilary E., Downing Richard, Low gravity rotational culture and the integration of immunomodulatory stem cells reduce human islet allo-reactivity, Clinical Transplantation, 29, 1, 2015. Crossref
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Gorczynski Reginald M., Regulation of transplantation tolerance by antigen-presenting cells, Transplantation Reviews, 19, 3, 2005. Crossref
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Jia Liang, Kovacs Jeffrey R., Zheng Ying, Gawalt Ellen S., Shen Hongmei, Meng Wilson S., Attenuated alloreactivity of dendritic cells engineered with surface-modified microspheres carrying a plasmid encoding interleukin-10, Biomaterials, 27, 9, 2006. Crossref
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Boros Peter, Liu Jianhua, Li Yansui, Bromberg Jonathan S., Organ transplantation in rodents: Novel applications of long-established methods, Transplant Immunology, 18, 1, 2007. Crossref
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Toyama H, Takada M, Tanaka T, Suzuki Y, Kuroda Y, Characterization of islet-infiltrating immunocytes after pancreas preservation by two-layer (UW/perfluorochemical) cold storage method, Transplantation Proceedings, 35, 4, 2003. Crossref
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Kupfer T., Beilke J.N., Pham K., Buhrman J., Gill R.G., “Indirect” Acute Islet Allograft Destruction in Nonobese Diabetic Mice Is Independent of Donor Major Histocompatibility Complex and Requires Host B Lymphocytes, Transplantation Proceedings, 40, 2, 2008. Crossref
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Boyd Ashleigh S., Wood Kathryn J., Goldberg Anna Carla, Characteristics of the Early Immune Response Following Transplantation of Mouse ES Cell Derived Insulin-Producing Cell Clusters, PLoS ONE, 5, 6, 2010. Crossref
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Burrack Adam L., Martinov Tijana, Fife Brian T., T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes, Frontiers in Endocrinology, 8, 2017. Crossref
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Toyama Hirochika, Takada Moriatsu, Suzuki Yasuyuki, Kuroda Yoshikazu, Activation of Macrophage-Associated Molecules after Brain Death in Islets, Cell Transplantation, 12, 1, 2003. Crossref
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Montanari Elisa, Gonelle‐Gispert Carmen, Seebach Jörg D., Knoll Michael F., Bottino Rita, Bühler Leo H., Immunological aspects of allogeneic pancreatic islet transplantation: a comparison between mouse and human, Transplant International, 32, 9, 2019. Crossref
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Plesner Annette, Liston Peter, Tan Rusung, Korneluk Robert G., Verchere C. Bruce, The X-Linked Inhibitor of Apoptosis Protein Enhances Survival of Murine Islet Allografts, Diabetes, 54, 9, 2005. Crossref
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Fiorina Paolo, Jurewicz Mollie, Tanaka Katsunori, Behazin Negin, Augello Andrea, Vergani Andrea, Von Adrian Uli, Smith Neal R., Sayegh Mohamed H., Abdi Reza, Characterization of Donor Dendritic Cells and Enhancement of Dendritic Cell Efflux With cc-Chemokine Ligand 21, Diabetes, 56, 4, 2007. Crossref