Выходит 6 номеров в год
ISSN Печать: 1040-8401
ISSN Онлайн: 2162-6472
IF:
1.3
5-Year IF:
2.6
Eigenfactor:
0.00079
JCI:
0.24
SJR:
0.429
SNIP:
0.287
CiteScore™::
2.7
H-Index:
81
Indexed in
Cellular Components and Mechanisms of Oral Tolerance Induction
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Краткое описание
Oral tolerance can be defined as an inhibition of specific immune responsiveness to subsequent parenteral injections of proteins to which an individual or animal has been previously exposed via the oral route. Multiple mechanisms of tolerance are induced by oral-fed antigens, but induction of regulatory CD4 T-cells expressing the transcription factor Foxp3 and the membrane-bound TGF-β stands out as the major players in oral tolerance. Oral antigen administration suppresses several animal models of autoimmune disease, including experimental autoimmune encephalomyelitis, uveitis, thyroiditis, myasthenia, arthritis, and diabetes, but also nonautoimmune inflammatory conditions such as asthma, atherosclerosis, graft rejection, allergy, and stroke. However, human trials have produced mixed results, and a great deal remains to be learned about the mechanisms of oral tolerance before it can be successfully applied to people. In this review, we highlight the cellular components involved in oral tolerance induction. A deep knowledge of these intricate cell interactions will pave the way for a successful application of antigen tolerance to treat autoimmune and nonautoimmune inflammatory diseases.
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Rezende Rafael M., Nakagaki Brenda N., Moreira Thais G., Lopes Juliana R., Kuhn Chantal, Tatematsu Bruna K., Boulenouar Selma, Maghzi Amir-Hadi, Rubino Stephen, Menezes Gustavo B., Chitnis Tanuja, Weiner Howard L., γδ T Cell–Secreted XCL1 Mediates Anti-CD3–Induced Oral Tolerance, The Journal of Immunology, 203, 10, 2019. Crossref
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Gusmao-Silva Guilherme, Aguiar Sarah Leão Fiorini, Miranda Mariana Camila Gonçalves, Guimarães Mauro Andrade, Alves Juliana Lima, Vieira Angélica Thomaz, Cara Denise Carmona, Miyoshi Anderson, Azevedo Vasco Ariston, Oliveira Rafael Pires, Faria Ana Maria Caetano, Hsp65-Producing Lactococcocus lactis Prevents Antigen-Induced Arthritis in Mice, Frontiers in Immunology, 11, 2020. Crossref
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Moreira Thais G., Mangani Davide, Cox Laura M., Leibowitz Jeffrey, Lobo Eduardo. L. C., Oliveira Mariana A., Gauthier Christian D., Nakagaki Brenda N., Willocq Valerie, Song Anya, Guo Lydia, Lima David C. A., Murugaiyan Gopal, Butovsky Oleg, Gabriely Galina, Anderson Ana C., Rezende Rafael M., Faria Ana Maria C., Weiner Howard L., PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis, Nature Communications, 12, 1, 2021. Crossref
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Srinivasan Aparajitha, Herzog Roland W., Khan Imran, Sherman Alexandra, Bertolini Thais, Wynn Tung, Daniell Henry, Preclinical development of plant‐based oral immune modulatory therapy for haemophilia B, Plant Biotechnology Journal, 19, 10, 2021. Crossref
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Pinheiro-Rosa Natália, Torres Lícia, Oliveira Mariana de Almeida, Andrade-Oliveira Marcos Felipe, Guimarães Mauro Andrade de Freitas, Coelho Monique Macedo, Alves Juliana de Lima, Maioli Tatiani Uceli, Faria Ana M Caetano, Oral tolerance as antigen-specific immunotherapy, Immunotherapy Advances, 1, 1, 2021. Crossref
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Rey Laura María, Gil José Ángel, Mateus José, Rodríguez Luz-Stella, Rondón Martín Alonso, Ángel Juana, Franco Manuel Antonio, López Susana, LAP + Cells Modulate Protection Induced by Oral Vaccination with Rhesus Rotavirus in a Neonatal Mouse Model , Journal of Virology, 93, 19, 2019. Crossref
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Gribonika Inta, Strömberg Anneli, Lebrero-Fernandez Cristina, Schön Karin, Moon James, Bemark Mats, Lycke Nils, Peyer’s patch T H 17 cells are dispensable for gut IgA responses to oral immunization , Science Immunology, 7, 73, 2022. Crossref