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Critical Reviews™ in Oncogenesis
Главный редактор: Benjamin Bonavida (open in a new tab)

Выходит 4 номеров в год

ISSN Печать: 0893-9675

ISSN Онлайн: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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Cellular Iron Metabolism in Prognosis and Therapy of Breast Cancer

Том 18, Выпуск 5, 2013, pp. 435-448
DOI: 10.1615/CritRevOncog.2013007784
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Краткое описание

Despite many recent advances, breast cancer remains a clinical challenge. Current issues include improving prognostic evaluation and increasing therapeutic options for women whose tumors are refractory to current frontline therapies. Iron metabolism is frequently disrupted in breast cancer, and may offer an opportunity to address these challenges. Iron enhances breast tumor initiation, growth and metastases. Iron may contribute to breast tumor initiation by promoting redox cycling of estrogen metabolites. Up-regulation of iron import and down-regulation of iron export may enable breast cancer cells to acquire and retain excess iron. Alterations in iron metabolism in macrophages and other cells of the tumor microenvironment may also foster breast tumor growth. Expression of iron metabolic genes in breast tumors is predictive of breast cancer prognosis. Iron chelators and other strategies designed to limit iron may have therapeutic value in breast cancer. The dependence of breast cancer on iron presents rich opportunities for improved prognostic evaluation and therapeutic intervention.

Ключевые слова: iron, breast cancer, estrogen
ЦИТИРОВАНО В
  1. Xiong Wei, Wang Li, Yu Fenglei, Regulation of cellular iron metabolism and its implications in lung cancer progression, Medical Oncology, 31, 7, 2014. Crossref

  2. Guo Wenli, Zhang Shuping, Chen Yue, Zhang Daoqiang, Yuan Lin, Cong Haibo, Liu Sijin, An important role of the hepcidin–ferroportin signaling in affecting tumor growth and metastasis, Acta Biochimica et Biophysica Sinica, 47, 9, 2015. Crossref

  3. Chekhun Vasyl’, Lukianova Natalia, Demash Dmytro, Borikun Tetiana, Chekhun Svyatoslav, Shvets Yulia, Manifestation of Key Molecular Genetic Markers in Pharmacocorrection of Endogenous Iron Metabolism in MCF-7 and MCF-7/DDP Human Breast Cancer Cells, CellBio, 02, 04, 2013. Crossref

  4. Qian Yi, Yin Chunyang, Chen Yue, Zhang Shuping, Jiang Li, Wang Fudi, Zhao Meirong, Liu Sijin, Estrogen contributes to regulating iron metabolism through governing ferroportin signaling via an estrogen response element, Cellular Signalling, 27, 5, 2015. Crossref

  5. Power Coombs Melanie R., Grant Taryn, Greenshields Anna L., Arsenault Daniel J., Holbein Bruce E., Hoskin David W., Inhibitory effect of iron withdrawal by chelation on the growth of human and murine mammary carcinoma and fibrosarcoma cells, Experimental and Molecular Pathology, 99, 2, 2015. Crossref

  6. Khan Parvez, Prakash Amresh, Haque Md. Anzarul, Islam Asimul, Hassan Md. Imtaiyaz, Ahmad Faizan, Structural basis of urea-induced unfolding: Unraveling the folding pathway of hemochromatosis factor E, International Journal of Biological Macromolecules, 91, 2016. Crossref

  7. Kazan Hasan Huseyin, Urfali-Mamatoglu Cagri, Gunduz Ufuk, Iron metabolism and drug resistance in cancer, BioMetals, 30, 5, 2017. Crossref

  8. Jung Michaela, Weigert Andreas, Mertens Christina, Rehwald Claudia, Brüne Bernhard, Iron Handling in Tumor-Associated Macrophages—Is There a New Role for Lipocalin-2?, Frontiers in Immunology, 8, 2017. Crossref

  9. Mertens Christina, Akam Eman Abureida, Rehwald Claudia, Brüne Bernhard, Tomat Elisa, Jung Michaela, Singh Pankaj K, Intracellular Iron Chelation Modulates the Macrophage Iron Phenotype with Consequences on Tumor Progression, PLOS ONE, 11, 11, 2016. Crossref

  10. Elnahas Marwa, Amin Magdy, Hussein Mohamed, Shanbhag Vinit, Ali Amal, Wall Judy, Isolation, Characterization and Bioactivities of an Extracellular Polysaccharide Produced from Streptomyces sp. MOE6, Molecules, 22, 9, 2017. Crossref

  11. Rosager Ann Mari, Sørensen Mia D., Dahlrot Rikke H., Hansen Steinbjørn, Schonberg David L., Rich Jeremy N., Lathia Justin D., Kristensen Bjarne W., Fillmore Helen, Transferrin receptor-1 and ferritin heavy and light chains in astrocytic brain tumors: Expression and prognostic value, PLOS ONE, 12, 8, 2017. Crossref

  12. El Hout Mouradi, Dos Santos Leïla, Hamaï Ahmed, Mehrpour Maryam, A promising new approach to cancer therapy: Targeting iron metabolism in cancer stem cells, Seminars in Cancer Biology, 53, 2018. Crossref

  13. Rejmund Marta, Mrozek-Wilczkiewicz Anna, Malarz Katarzyna, Pyrkosz-Bulska Monika, Gajcy Kamila, Sajewicz Mieczyslaw, Musiol Robert, Polanski Jaroslaw, Palit Deb Swati, Piperazinyl fragment improves anticancer activity of Triapine, PLOS ONE, 13, 4, 2018. Crossref

  14. Jakubaszek Marta, Goud Bruno, Ferrari Stefano, Gasser Gilles, Mechanisms of action of Ru(ii) polypyridyl complexes in living cells upon light irradiation, Chemical Communications, 54, 93, 2018. Crossref

  15. Chua Anita CG, Knuiman Matthew W, Trinder Debbie, Divitini Mark L, Olynyk John K, Higher concentrations of serum iron and transferrin saturation but not serum ferritin are associated with cancer outcomes, The American Journal of Clinical Nutrition, 104, 3, 2016. Crossref

  16. Yang Jie, Li Wei, Luo Lihua, Jiang Mengshi, Zhu Chunqi, Qin Bing, Yin Hang, Yuan Xiaoling, Yin Xiaoyi, Zhang Junlei, Luo Zhenyu, Du Yongzhong, You Jian, Hypoxic tumor therapy by hemoglobin-mediated drug delivery and reversal of hypoxia-induced chemoresistance, Biomaterials, 182, 2018. Crossref

  17. Bajbouj Khuloud, Shafarin Jasmin, Hamad Mawieh, High-Dose Deferoxamine Treatment Disrupts Intracellular Iron Homeostasis, Reduces Growth, and Induces Apoptosis in Metastatic and Nonmetastatic Breast Cancer Cell Lines, Technology in Cancer Research & Treatment, 17, 2018. Crossref

  18. Greenshields Anna L., Power Coombs Melanie R., Fernando Wasundara, Holbein Bruce E., Hoskin David W., DIBI, a novel 3-hydroxypyridin-4-one chelator iron-binding polymer, inhibits breast cancer cell growth and functions as a chemosensitizer by promoting S-phase DNA damage, BioMetals, 32, 6, 2019. Crossref

  19. Petrosino Maria, Pasquo Alessandra, Novak Leonore, Toto Angelo, Gianni Stefano, Mantuano Elide, Veneziano Liana, Minicozzi Velia, Pastore Annalisa, Puglisi Rita, Capriotti Emidio, Chiaraluce Roberta, Consalvi Valerio, Characterization of human frataxin missense variants in cancer tissues, Human Mutation, 40, 9, 2019. Crossref

  20. Mora Javier, Mertens Christina, Meier Julia K., Fuhrmann Dominik C., Brüne Bernhard, Jung Michaela, Strategies to Interfere with Tumor Metabolism through the Interplay of Innate and Adaptive Immunity, Cells, 8, 5, 2019. Crossref

  21. Chang Vicky C., Cotterchio Michelle, Khoo Edwin, Iron intake, body iron status, and risk of breast cancer: a systematic review and meta-analysis, BMC Cancer, 19, 1, 2019. Crossref

  22. Yaghoobi Fatemeh, Karimi shervedani Reza, Torabi Mostafa, Kefayat Amirhosein, Ghahremani Fatemeh, Farzadniya Amin, Therapeutic effect of deferrioxamine conjugated to PEGylated gold nanoparticles and complexed with Mn(II) beside the CT scan and MRI diagnostic studies, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 583, 2019. Crossref

  23. Gasparetto Maura, Pei Shanshan, Minhajuddin Mohammad, Stevens Brett, Smith Clayton A., Seligman Paul, Low ferroportin expression in AML is correlated with good risk cytogenetics, improved outcomes and increased sensitivity to chemotherapy, Leukemia Research, 80, 2019. Crossref

  24. Pamphlett Roger, Satgunaseelan Laveniya, Kum Jew Stephen, Doble Philip A., Bishop David P., Hu Yi, Elemental bioimaging shows mercury and other toxic metals in normal breast tissue and in breast cancers, PLOS ONE, 15, 1, 2020. Crossref

  25. Rychtarcikova Zuzana, Lettlova Sandra, Tomkova Veronika, Korenkova Vlasta, Langerova Lucie, Simonova Ekaterina, Zjablovskaja Polina, Alberich-Jorda Meritxell, Neuzil Jiri, Truksa Jaroslav, Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism, Oncotarget, 8, 4, 2017. Crossref

  26. Jiang Honglin, Muir Ryan K., Gonciarz Ryan L., Olshen Adam, Yeh Iwei, Hann Byron C., Zhao Ning, Wang Yung-hua, Behr Spencer C., Evans Michael J., Collisson Eric A., Renslo Adam R., Exploiting KRAS-Driven Ferroaddiction in Cancer Through Ferrous Iron-Activatable Drug Conjugates (FeADC), SSRN Electronic Journal , 2020. Crossref

  27. Cheng Gang, Zielonka Jacek, Hardy Micael, Ouari Olivier, Chitambar Christopher R., Dwinell Michael B., Kalyanaraman Balaraman, Synergistic inhibition of tumor cell proliferation by metformin and mito-metformin in the presence of iron chelators, Oncotarget, 10, 37, 2019. Crossref

  28. Chen Gang , Guo Guangqi , Zhou Xiaodong , Chen Hongxia , Potential mechanism of ferroptosis in pancreatic cancer (Review), Oncology Letters, 2019. Crossref

  29. Chen Ying, Fan Zhimin, Yang Ye, Gu Chunyan, Iron metabolism and its contribution to cancer (Review), International Journal of Oncology, 2019. Crossref

  30. Shibabaw Tewodros, Teferi Banchamlak, Molla Meseret Derbew, Ayelign Birhanu, <p>Inflammation Mediated Hepcidin-Ferroportin Pathway and Its Therapeutic Window in Breast Cancer</p>, Breast Cancer: Targets and Therapy, Volume 12, 2020. Crossref

  31. Henry Kelly E., Dilling Thomas R., Abdel-Atti Dalya, Edwards Kimberly J., Evans Michael J., Lewis Jason S., Noninvasive 89Zr-Transferrin PET Shows Improved Tumor Targeting Compared with 18F-FDG PET in MYC-Overexpressing Human Triple-Negative Breast Cancer, Journal of Nuclear Medicine, 59, 1, 2018. Crossref

  32. Khan Rizwan Ullah, Hassan Amber, Tanvir Imrana, Ehsan Kashifa , Prognostic Signicance of Cellular Iron Metabolism in Breast Cancer , Pakistan BioMedical Journal, 1, 1, 2018. Crossref

  33. Liu Kai-Yan, Feng Xiao-Li, Mo Xiong-Fei, Lin Fang-Yu, Zhang Xin, Huang Chu-Yi, Abulimiti Alinuer, Li Lei, Zhang Cai-Xia, Iron intake with the risk of breast cancer among Chinese women: a case–control study, Public Health Nutrition, 24, 17, 2021. Crossref

  34. Xiaofei Jiang, Mingqing Shi, Miao Sui, Yizhen Yuan, Shuang Zhang, Qinhua Xia, Kai Zhao, Oleanolic acid inhibits cervical cancer Hela cell proliferation through modulation of the ACSL4 ferroptosis signaling pathway, Biochemical and Biophysical Research Communications, 545, 2021. Crossref

  35. Yang Jianhui, Xu Jin, Zhang Bo, Tan Zhen, Meng Qingcai, Hua Jie, Liu Jiang, Wang Wei, Shi Si, Yu Xianjun, Liang Chen, Ferroptosis: At the Crossroad of Gemcitabine Resistance and Tumorigenesis in Pancreatic Cancer, International Journal of Molecular Sciences, 22, 20, 2021. Crossref

  36. Qian Yi, Zhang Shuping, Guo Wenli, Ma Juan, Chen Yue, Wang Lei, Zhao Meirong, Liu Sijin, Polychlorinated Biphenyls (PCBs) Inhibit Hepcidin Expression through an Estrogen-Like Effect Associated with Disordered Systemic Iron Homeostasis, Chemical Research in Toxicology, 28, 4, 2015. Crossref

  37. Gibbons Jessica A., Kanwar Jagat R., Kanwar Rupinder K., Iron-free and iron-saturated bovine lactoferrin inhibit survivin expression and differentially modulate apoptosis in breast cancer, BMC Cancer, 15, 1, 2015. Crossref

  38. Crake Rebekah L. I., Burgess Eleanor R., Royds Janice A., Phillips Elisabeth, Vissers Margreet C. M., Dachs Gabi U., The Role of 2-Oxoglutarate Dependent Dioxygenases in Gliomas and Glioblastomas: A Review of Epigenetic Reprogramming and Hypoxic Response, Frontiers in Oncology, 11, 2021. Crossref

  39. Wigner Paulina, Zielinski Krzysztof, Labieniec-Watala Magdalena, Marczak Agnieszka, Szwed Marzena, Doxorubicin–transferrin conjugate alters mitochondrial homeostasis and energy metabolism in human breast cancer cells, Scientific Reports, 11, 1, 2021. Crossref

  40. Liu Zixuan, Xia Xiaomin, Lv Xuying, Song Erqun, Song Yang, Iron-bearing nanoparticles trigger human umbilical vein endothelial cells ferroptotic responses by promoting intracellular iron level, Environmental Pollution, 287, 2021. Crossref

  41. Zhang Zheng, Jiang Hao-Jie, Yang Huan-Huan, Ren Jin-Jin, Jiang Guo-Qin, Xu Jia-Ying, Qin Li-Qiang, Growth differentiation factor-15 and lactoferrin immuno-expression in breast cancer: relationship with body iron-status and survival outcome, BioMetals, 34, 2, 2021. Crossref

  42. Ali Amjad, Shafarin Jasmin, Abu Jabal Rola, Aljabi Nour, Hamad Mohamad, Sualeh Muhammad Jibran, Unnikannan Hema, Hamad Mawieh, Ferritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c‐MYC, FEBS Open Bio, 11, 11, 2021. Crossref

  43. Trudu Federica, Amato Filippo, Vaňhara Petr, Pivetta Tiziana, Peña-Méndez E.M., Havel Josef, Coordination compounds in cancer: Past, present and perspectives, Journal of Applied Biomedicine, 13, 2, 2015. Crossref

  44. Dong Dandan, Zhang Gejing, Yang Jiancheng, Zhao Bin, Wang Shenghang, Wang Luyao, Zhang Ge, Shang Peng, The role of iron metabolism in cancer therapy focusing on tumor‐associated macrophages, Journal of Cellular Physiology, 234, 6, 2019. Crossref

  45. Jiang Honglin, Muir Ryan K., Gonciarz Ryan L., Olshen Adam B., Yeh Iwei, Hann Byron C., Zhao Ning, Wang Yung-hua, Behr Spencer C., Korkola James E., Evans Michael J., Collisson Eric A., Renslo Adam R., Ferrous iron–activatable drug conjugate achieves potent MAPK blockade in KRAS-driven tumors, Journal of Experimental Medicine, 219, 4, 2022. Crossref

  46. Zhu Liyun, Meng Danni, Wang Xu, Chen Xuerui, Ferroptosis-Driven Nanotherapeutics to Reverse Drug Resistance in Tumor Microenvironment, ACS Applied Bio Materials, 5, 6, 2022. Crossref

  47. Kawabata Tsuyoshi, Yoshimori Tamotsu, Beyond starvation: An update on the autophagic machinery and its functions, Journal of Molecular and Cellular Cardiology, 95, 2016. Crossref

  48. Jung Michaela, Mertens Christina, Bauer Rebekka, Rehwald Claudia, Brüne Bernhard, Lipocalin-2 and iron trafficking in the tumor microenvironment, Pharmacological Research, 120, 2017. Crossref

  49. Qin Hong, Zeng Weibiao, Lou Yongfu, Mendelian randomization study indicates lack of causal associations between iron status and lung cancer, Medicine, 101, 29, 2022. Crossref

  50. Chen Shuming, Li He, Chen Siyu, Wang Bing, Zhang Kaixiang, BMI1 promotes the proliferation and inhibits autophagy of breast cancer cells by activating COPZ1, Clinical and Translational Oncology, 24, 11, 2022. Crossref

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