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Critical Reviews™ in Oncogenesis
Главный редактор: Benjamin Bonavida (open in a new tab)

Выходит 4 номеров в год

ISSN Печать: 0893-9675

ISSN Онлайн: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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Surgical Resection of Retroperitoneal Sarcomas: Analysis of Factors Determining Outcome

Том 21, Выпуск 1-2, 2016, pp. 105-113
DOI: 10.1615/CritRevOncog.2016016967
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Краткое описание

Introduction: Retroperitoneal sarcomas (RS) are rare malignant tumors characterized by high local recurrence rates and poor survival, Aggressive surgical resection may improve local recurrence rates and disease-specific survival (DSS), The aim of our study was to determine predictors of survival and local recurrence in primary RS.
Methods: We performed a retrospective analysis and identified 68 patients who underwent surgical resection of a primary RS between 1985 and 2010, Clinical and pathologic variables were used to create univariate and multivariate models for both survival and recurrence.
Results: 68 patients (37% male) with mean age 59 (range 25-84) underwent surgical resection for RS. Median tumor size was 12.0 cm (range 7.0-18.0 cm). 75% of tumors were intermediate/high grade, Incontinuity organ resection was performed in 29 (43%) patients. Seven patients (10%) underwent vascular resection with graft placement. Overall survival at 5, 10 and 15 years was 55%, 42%, and 33%, respectively. Grade (p<0.007), tumor size (p=0.048) and margin status (p<0.05) were found to significantly affect local recurrence. In a multivariate analysis, recurrent disease (p<0.001), age (p<0.003) and high/intermediate grade (p<0.001) significantly affected DSS. Incontinuity organ resection did not significantly affect recurrence (HR = 1.1, CI 0.63 − 1.85) or survival (HR = 1.4, CI 0.8 − 2.9).
Conclusion: Surgical resection of RS affords the best chance of survival. Incontinuity organ resection did not affect outcome on multivariate analysis; however, margin status did significantly affect recurrence and could not be achieved without aggressive resection of incontinuity organs.

Ключевые слова: Surgery, Retroperitoneal Sarcomas, Outcomes
ЦИТИРОВАНО В
  1. Patkar Shraddha, Kattepur Abhay K, Shinde Rajesh, Goel Mahesh, Retroperitoneal Sarcomas: Prognostic Factors and Outcomes of a Series of Patients Treated at a Single Institution, Indian Journal of Surgical Oncology, 11, 2, 2020. Crossref

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