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Critical Reviews™ in Oncogenesis
Главный редактор: Benjamin Bonavida (open in a new tab)

Выходит 4 номеров в год

ISSN Печать: 0893-9675

ISSN Онлайн: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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The Cbl Family of Signal Transduction Molecules

Том 8, Выпуск 4, 1997, pp. 359-380
DOI: 10.1615/CritRevOncog.v8.i4.50
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Краткое описание

This review summarizes the current knowledge about the structure, expression, and signaling function of Cbl. A mutant Cbl form (v-Cbl) was first identified as the product of the Cas-NS-1 murine retrovirus that induces lymphomas and leukemias. Two members of the Cbl family have since been defined in mammals (c-Cbl and Cbl-b), one in C. elegans (Sli-1) and one in Drosophila (D-Cbl). There is high conservation between Cbl species in the amino-terminal region that contains a putative phosphotyrosine binding domain and a Ring finger motif. In the carboxy-terminal region, mammalian Cbl forms share a proline-rich stretch, conserved tyrosine residues, and a leucine zipper. Cbl participates in signaling by receptor protein tyrosine kinases, as well as antigen and cytokine receptors that signal via associated cytoplasmic protein tyrosine kinases. Cbl is recruited to the tyrosine kinase module of these receptors and tyrosine phosphorylated after cellular activation. It functions as a scaffold protein and associates with SH2 and SH3 domain containing molecules, including the Crk adaptor family and Vav. By analogy with the C. elegans homologue Sli-1, Cbl is proposed to be a negative regulator of receptor tyrosine kinase signaling. After deletion mutation in a region close to the Ring finger, c-Cbl becomes oncogenic. Such mutations are suggested to result in a structural alteration, allowing oncogenic mutants to displace wild-type c-Cbl from the receptor complex and to abrogate its negative regulatory function.

ЦИТИРОВАНО В
  1. Xue Rong, Hao Dan-Dan, Sun Ji-Ping, Li Wen-Wen, Zhao Man-Man, Li Xing-Hui, Chen Ying, Zhu Jian-Hua, Ding Ying-Jiong, Liu Jun, Zhu Yi-Chun, Hydrogen Sulfide Treatment Promotes Glucose Uptake by Increasing Insulin Receptor Sensitivity and Ameliorates Kidney Lesions in Type 2 Diabetes, Antioxidants & Redox Signaling, 19, 1, 2013. Crossref

  2. Hazeki Kaoru, Hazeki Osamu, Matsuo Tsuyoshi, Seya Tsukasa, Yamashita Toshiyuki, Nagasawa Shigeharu, Band Hamid, Ui Michio, Role of Syk in Fcγ receptor-coupled tyrosine phosphorylation of Cbl in a manner susceptible to inhibition by protein kinase C, European Journal of Immunology, 29, 10, 1999. Crossref

  3. Drost Jessica, Nonis David, Eich Florian, Leske Oliver, Damrath Ewa, Brunt Ewout R., Lastres-Becker Isabel, Heumann Rolf, Nowock Joachim, Auburger Georg, Ataxin-2 Modulates the Levels of Grb2 and Src but Not Ras Signaling, Journal of Molecular Neuroscience, 51, 1, 2013. Crossref

  4. Brenner Birgit, Kadel Stephanie, Birle Alexandra, Linderkamp Otwin, L-Selectin Tyrosine Phosphorylates Cbl and Induces Association of Tyrosine-Phosphorylated Cbl with CrkL and Grb2, Biochemical and Biophysical Research Communications, 282, 1, 2001. Crossref

  5. van der Voort Robbert, Keehnen Robert M.J., Beuling Esther A., Spaargaren Marcel, Pals Steven T., Regulation of Cytokine Signaling by B Cell Antigen Receptor and Cd40-Controlled Expression of Heparan Sulfate Proteoglycans, Journal of Experimental Medicine, 192, 8, 2000. Crossref

  6. Wang Yingxiao, Flores Leona, Lu Shaoying, Miao Hui, Li Yi-Shuan, Chien Shu, Shear Stress Regulates the Flk-1/Cbl/PI3K/NF-κB Pathway Via Actin and Tyrosine Kinases, Cellular and Molecular Bioengineering, 2, 3, 2009. Crossref

  7. Sun Qingxiang, Ng Cherlyn, Guy Graeme R., Sivaraman J., An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding, FEBS Letters, 585, 2, 2011. Crossref

  8. Suzue Naoto, Nikawa Takeshi, Onishi Yuko, Yamada Chiharu, Hirasaka Katsuya, Ogawa Takayuki, Furochi Harumi, Kosaka Hirofumi, Ishidoh Kazumi, Gu Hua, Takeda Shin'ichi, Ishimaru Naozumi, Hayashi Yoshio, Yamamoto Hironori, Kishi Kyoichi, Yasui Natsuo, Ubiquitin Ligase Cbl-b Downregulates Bone Formation Through Suppression of IGF-I Signaling in Osteoblasts During Denervation, Journal of Bone and Mineral Research, 21, 5, 2006. Crossref

  9. van Leeuwen Jeroen EM, Samelson Lawrence E, T cell antigen-receptor signal transduction, Current Opinion in Immunology, 11, 3, 1999. Crossref

  10. Lorenzo Mayra E, Ploegh Hidde L, Tirabassi Rebecca S, Viral immune evasion strategies and the underlying cell biology, Seminars in Immunology, 13, 1, 2001. Crossref

  11. Ettenberg Seth A., Rubinstein Yaffa R., Banerjee Priya, Nau Marion M., Keane Maccon M., Lipkowitz Stanley, cbl-b Inhibits EGF-Receptor-Induced Apoptosis by Enhancing Ubiquitination and Degradation of Activated Receptors, Molecular Cell Biology Research Communications, 2, 2, 1999. Crossref

  12. Chodniewicz David, Klemke Richard L, Regulation of integrin-mediated cellular responses through assembly of a CAS/Crk scaffold, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1692, 2-3, 2004. Crossref

  13. Medema Jan Paul, Borst Jannie, T cell signaling:, Human Immunology, 60, 5, 1999. Crossref

  14. Jacobs Heinz, TCR-independent T cell development mediated by gain-of-oncogene function or loss-of-tumor-suppressor gene function, Seminars in Immunology, 12, 5, 2000. Crossref

  15. Corsois Laurent, Quatannens Brigitte, Dumont Patrick, Aumercier Marc, Defresne Marie-Paule, Régnier Daniel C.L., Association of a new c-Cbl related protein with the very first stages of apoptosis induction, Cancer Detection and Prevention, 26, 2, 2002. Crossref

  16. Leo Albrecht, Schraven Burkhart, Adapters in lymphocyte signalling, Current Opinion in Immunology, 13, 3, 2001. Crossref

  17. Yasuda Tomoharu, Maeda Akito, Kurosaki Mari, Tezuka Tohru, Hironaka Katsunori, Yamamoto Tadashi, Kurosaki Tomohiro, Cbl Suppresses B Cell Receptor–Mediated Phospholipase C (Plc)-γ2 Activation by Regulating B Cell Linker Protein–Plc-γ2 Binding, Journal of Experimental Medicine, 191, 4, 2000. Crossref

  18. Moghal Nadeem, Sternberg Paul W, Multiple positive and negative regulators of signaling by the EGF-receptor, Current Opinion in Cell Biology, 11, 2, 1999. Crossref

  19. Pai Li-Mei, Barcelo Gail, Schüpbach Trudi, D-cbl, a Negative Regulator of the Egfr Pathway, Is Required for Dorsoventral Patterning in Drosophila Oogenesis, Cell, 103, 1, 2000. Crossref

  20. Wojchowski Don M., Gregory Richard C., Miller Chris P., Pandit Ajay K., Pircher Tony J., Signal Transduction in the Erythropoietin Receptor System, Experimental Cell Research, 253, 1, 1999. Crossref

  21. Doyu Manabu, Sawada Ko-ichi, Mitsuma Norimasa, Niwa Jun-ichi, Yoshimoto Makoto, Fujii Yasuyuki, Sobue Gen, Kato Kikuya, Gene expression profile in Alzheimer’s brain screened by molecular indexing, Molecular Brain Research, 87, 1, 2001. Crossref

  22. Bock O, Kreipe HH, Molecular studies in myeloproliferative and myelodysplastic/myeloproliferative neoplasms, in Blood and Bone Marrow Pathology, 2011. Crossref

  23. Sawasdikosol Sansana, Pratt Joanne C., Meng Wuyi, Eck Michael J., Burakoff Steven J., Adapting to multiple personalities: Cbl is also a RING finger ubiquitin ligase, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1471, 1, 2000. Crossref

  24. Wang Yingxiao, Miao Hui, Li Song, Chen Kuang-Den, Li Yi-Shuan, Yuan Suli, Shyy John Y.-J., Chien Shu, Interplay between integrins and FLK-1 in shear stress-induced signaling, American Journal of Physiology-Cell Physiology, 283, 5, 2002. Crossref

  25. Yokouchi Masahiro, Kondo Takeshi, Houghton Adam, Bartkiewicz Marcjanna, Horne William C., Zhang Hui, Yoshimura Akihiko, Baron Roland, Ligand-induced Ubiquitination of the Epidermal Growth Factor Receptor Involves the Interaction of the c-Cbl RING Finger and UbcH7, Journal of Biological Chemistry, 274, 44, 1999. Crossref

  26. Rosenkranz Stephan, Ikuno Yasushi, Leong Fee Lai, Klinghoffer Richard A., Miyake Sachiko, Band Hamid, Kazlauskas Andrius, Src Family Kinases Negatively Regulate Platelet-derived Growth Factor α Receptor-dependent Signaling and Disease Progression, Journal of Biological Chemistry, 275, 13, 2000. Crossref

  27. Wang Yingxiao, Chang Joann, Li Yi-Chen, Li Yi-Shuan, Shyy John Y.-J., Chien Shu, Shear stress and VEGF activate IKK via the Flk-1/Cbl/Akt signaling pathway, American Journal of Physiology-Heart and Circulatory Physiology, 286, 2, 2004. Crossref

  28. Katsumata Osamu, Hara-Yokoyama Miki, Sautès-Fridman Catherine, Nagatsuka Yasuko, Katada Toshiaki, Hirabayashi Yoshio, Shimizu Kazufumi, Fujita-Yoshigaki Junko, Sugiya Hiroshi, Furuyama Shunsuke, Association of FcγRII with Low-Density Detergent-Resistant Membranes Is Important for Cross-Linking-Dependent Initiation of the Tyrosine Phosphorylation Pathway and Superoxide Generation, The Journal of Immunology, 167, 10, 2001. Crossref

  29. Rao Navin, Lupher Mark L., Ota Satoshi, Reedquist Kris A., Druker Brian J., Band Hamid, The Linker Phosphorylation Site Tyr292 Mediates the Negative Regulatory Effect of Cbl on ZAP-70 in T Cells, The Journal of Immunology, 164, 9, 2000. Crossref

  30. Cohen Shai, Dadi Harjit, Shaoul Ester, Sharfe Nigel, Roifman Chaim M., Cloning and Characterization of a Lymphoid-Specific, Inducible Human Protein Tyrosine Phosphatase, Lyp, Blood, 93, 6, 1999. Crossref

  31. Taher Taher E. I., Tjin Esther P. M., Beuling Esther A., Borst Jannie, Spaargaren Marcel, Pals Steven T., c-Cbl Is Involved in Met Signaling in B Cells and Mediates Hepatocyte Growth Factor-Induced Receptor Ubiquitination, The Journal of Immunology, 169, 7, 2002. Crossref

  32. Luo Hongyu, Wan Xiaochun, Wu Yulian, Wu Jiangping, Cross-Linking of EphB6 Resulting in Signal Transduction and Apoptosis in Jurkat Cells, The Journal of Immunology, 167, 3, 2001. Crossref

  33. Protein Kinase C-Theta (PKCθ): A Rheostat in T cell Signaling and Cancer, Journal of Clinical & Experimental Immunology, 1, 2, 2016. Crossref

  34. Lazaar Aili L., Krymskaya Vera P., Das Susan K. P., VCAM-1 Activates Phosphatidylinositol 3-Kinase and Induces p120CblPhosphorylation in Human Airway Smooth Muscle Cells, The Journal of Immunology, 166, 1, 2001. Crossref

  35. Lyle Chimera L., Belghasem Mostafa, Chitalia Vipul C., c-Cbl: An Important Regulator and a Target in Angiogenesis and Tumorigenesis, Cells, 8, 5, 2019. Crossref

  36. Caligiuri Michael A., Briesewitz Roger, Yu Jianhua, Wang Lisheng, Wei Min, Arnoczky Kristy J., Marburger Trent B., Wen Jing, Perrotti Danilo, Bloomfield Clara D., Whitman Susan P., Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia, Blood, 110, 3, 2007. Crossref

  37. de Melker Annemieke A., van der Horst Gerda, Borst Jannie, c-Cbl directs EGF receptors into an endocytic pathway that involves the ubiquitin-interacting motif of Eps15, Journal of Cell Science, 117, 21, 2004. Crossref

  38. van Leeuwen Jeroen E.M., Paik Paul K., Samelson Lawrence E., Activation of Nuclear Factor of Activated T Cells-(NFAT) and Activating Protein 1 (AP-1) by Oncogenic 70Z Cbl Requires an Intact Phosphotyrosine Binding Domain but Not Crk(L) or p85 Phosphatidylinositol 3-Kinase Association, Journal of Biological Chemistry, 274, 8, 1999. Crossref

  39. Ettenberg Seth A., Magnifico Alessandra, Cuello Mauricio, Nau Marion M., Rubinstein Yaffa R., Yarden Yosef, Weissman Allan M., Lipkowitz Stan, Cbl-b-dependent Coordinated Degradation of the Epidermal Growth Factor Receptor Signaling Complex, Journal of Biological Chemistry, 276, 29, 2001. Crossref

  40. Miyake Sachiko, Mullane-Robinson Karen P., Lill Nancy L., Douillard Patrice, Band Hamid, Cbl-mediated Negative Regulation of Platelet-derived Growth Factor Receptor-dependent Cell Proliferation, Journal of Biological Chemistry, 274, 23, 1999. Crossref

  41. Isakov Noah, Altman Amnon, Protein Kinase Cθ in T Cell Activation, Annual Review of Immunology, 20, 1, 2002. Crossref

  42. Scaife R.M., Langdon W.Y., c-Cbl localizes to actin lamellae and regulates lamellipodia formation and cell morphology, Journal of Cell Science, 113, 2, 2000. Crossref

  43. de Melker Annemieke A., van der Horst Gerda, Calafat Jero, Jansen Hans, Borst Jannie, c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route, Journal of Cell Science, 114, 11, 2001. Crossref

  44. Keane Maccon M, Ettenberg Seth A, Nau Marion M, Banerjee Priya, Cuello Mauricio, Penninger Josef, Lipkowitz Stan, cbl-3: a new mammalian cbl family protein, Oncogene, 18, 22, 1999. Crossref

  45. Wong Esther Sook Miin, Lim Jormay, Low Boon Chuan, Chen Qiping, Guy Graeme R., Evidence for Direct Interaction between Sprouty and Cbl, Journal of Biological Chemistry, 276, 8, 2001. Crossref

  46. van Leeuwen Jeroen E. M., Paik Paul K., Samelson Lawrence E., The Oncogenic 70Z Cbl Mutation Blocks the Phosphotyrosine Binding Domain-Dependent Negative Regulation of ZAP-70 by c-Cbl in Jurkat T Cells, Molecular and Cellular Biology, 19, 10, 1999. Crossref

  47. Joazeiro Claudio A. P., Wing Simon S., Huang Han-kuei, Leverson Joel D., Hunter Tony, Liu Yun-Cai, The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase, Science, 286, 5438, 1999. Crossref

  48. Lill Nancy L., Douillard Patrice, Awwad Rana A., Ota Satoshi, Lupher Mark L., Miyake Sachiko, Meissner-Lula Nichole, Hsu Victor W., Band Hamid, The Evolutionarily Conserved N-terminal Region of Cbl Is Sufficient to Enhance Down-regulation of the Epidermal Growth Factor Receptor, Journal of Biological Chemistry, 275, 1, 2000. Crossref

  49. Ota Satoshi, Hazeki Kaoru, Rao Navin, Lupher Mark L., Andoniou Christopher E., Druker Brian, Band Hamid, The RING Finger Domain of Cbl Is Essential for Negative Regulation of the Syk Tyrosine Kinase, Journal of Biological Chemistry, 275, 1, 2000. Crossref

  50. Feller Stephan M, Crk family adaptors–signalling complex formation and biological roles, Oncogene, 20, 44, 2001. Crossref

  51. Broome Martin A, Galisteo Maria L, Schlessinger Joseph, Courtneidge Sara A, The proto-oncogene c-Cbl is a negative regulator of DNA synthesis initiated by both receptor and cytoplasmic tyrosine kinases, Oncogene, 18, 18, 1999. Crossref

  52. Chen Ceshi, Seth Arun K., Aplin Andrew E., Genetic and Expression Aberrations of E3 Ubiquitin Ligases in Human Breast Cancer, Molecular Cancer Research, 4, 10, 2006. Crossref

  53. van der Voort Robbert, Taher Taher E.I., Wielenga Vera J.M., Spaargaren Marcel, Prevo Remko, Smit Lia, David Guido, Hartmann Guido, Gherardi Ermanno, Pals Steven T., Heparan Sulfate-modified CD44 Promotes Hepatocyte Growth Factor/Scatter Factor-induced Signal Transduction through the Receptor Tyrosine Kinase c-Met, Journal of Biological Chemistry, 274, 10, 1999. Crossref

  54. Ettenberg Seth A, Keane Maccon M, Nau Marion M, Frankel Mark, Wang Ling-Mei, Pierce Jacalyn H, Lipkowitz Stan, cbl-b inhibits epidermal growth factor receptor signaling, Oncogene, 18, 10, 1999. Crossref

  55. Yu Guang, Luo Hongyu, Wu Yulian, Wu Jiangping, EphrinB1 Is Essential in T-cell-T-cell Co-operation during T-cell Activation, Journal of Biological Chemistry, 279, 53, 2004. Crossref

  56. Lee Junho, Ahnn Joohong, Bae Suk-Chul, Homologs of RUNX and CBFβ/PEBP2β in C. elegans, Oncogene, 23, 24, 2004. Crossref

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