Доступ предоставлен для: Guest
Critical Reviews™ in Oncogenesis
Главный редактор: Benjamin Bonavida (open in a new tab)

Выходит 4 номеров в год

ISSN Печать: 0893-9675

ISSN Онлайн: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Immunosenescence and Cancer

Том 18, Выпуск 6, 2013, pp. 489-513
DOI: 10.1615/CritRevOncog.2013010597
Get accessGet access

Краткое описание

The immune system, interacting intimately with the cancer cells in a tumor, may combat or favor cancer development and progression, or both. One of the most important risk factors for solid cancers is age. With increasing age, numerous alterations at multiple levels including molecular, cellular, organ, and systemic are occurring. With age many physiological systems are changing, including the immune system. Several alterations occur in both arms of the immune system with aging. Although the innate immune system shows changes with aging, the most important alterations occur in the adaptive immune system, especially involving T cells. Many changes in the immune system may decrease its capacity to combat the emerging or progressing tumor. Further, the age-related immune changes may favor the cancer development. The most important changes which may decrease the immune response efficiency are the changes in T cell functions and phenotypes, concomitant with the presence of a low-grade inflammation. A consensus is now emerging in oncology that not only the cancer cells themselves should be studied but also their macro- and microenvironments. In this context, the study of the interrelation of the immune response and the tumor at various stages is essential to enhance our capacity for intervention in elderly cancer patients.

ЦИТИРОВАНО В
  1. Martinet Kim, Bloquet Stéphane, Bourgeois Christine, Ageing combines CD4 T cell lymphopenia in secondary lymphoid organs and T cell accumulation in gut associated lymphoid tissue, Immunity & Ageing, 11, 1, 2014. Crossref

  2. Bailur Jithendra Kini, Derhovanessian Evelyna, Gueckel Brigitte, Pawelec Graham, Prognostic impact of circulating Her-2-reactive T-cells producing pro- and/or anti-inflammatory cytokines in elderly breast cancer patients, Journal for ImmunoTherapy of Cancer, 3, 1, 2015. Crossref

  3. Golomb L, Sagiv A, Pateras I S, Maly A, Krizhanovsky V, Gorgoulis V G, Oren M, Ben-Yehuda A, Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy, Cell Death & Differentiation, 22, 11, 2015. Crossref

  4. Zhu Wei, Germain Claire, Liu Zheng, Sebastian Yinong, Devi Priyanka, Knockaert Samantha, Brohawn Philip, Lehmann Kim, Damotte Diane, Validire Pierre, Yao Yihong, Valge-Archer Viia, Hammond Scott A, Dieu-Nosjean Marie-Caroline, Higgs Brandon W, A high density of tertiary lymphoid structure B cells in lung tumors is associated with increased CD4+T cell receptor repertoire clonality, OncoImmunology, 4, 12, 2015. Crossref

  5. Bailur Jithendra Kini, Gueckel Brigitte, Derhovanessian Evelyna, Pawelec Graham, Presence of circulating Her2-reactive CD8 + T-cells is associated with lower frequencies of myeloid-derived suppressor cells and regulatory T cells, and better survival in older breast cancer patients, Breast Cancer Research, 17, 1, 2015. Crossref

  6. Rodriguez-Zhurbenko Nely, Rabade-Chediak Maura, Martinez Darel, Griñan Tania, Hernandez Ana Maria, Anti-NeuGcGM3 reactivity: a possible role of natural antibodies and B-1 cells in tumor immunosurveillance, Annals of the New York Academy of Sciences, 1362, 1, 2015. Crossref

  7. Sarkozy Clémentine, Salles Gilles, Falandry Claire, The Biology of Aging and Lymphoma: a Complex Interplay, Current Oncology Reports, 17, 7, 2015. Crossref

  8. Krenzien Felix, ElKhal Abdallah, Quante Markus, Rodriguez Cetina Biefer Hector, Hirofumi Uehara, Gabardi Steven, Tullius Stefan G., A Rationale for Age-Adapted Immunosuppression in Organ Transplantation, Transplantation, 99, 11, 2015. Crossref

  9. Baëhl Sarra, Garneau Hugo, Le Page Aurélie, Lorrain Dominique, Viens Isabelle, Svotelis Amy, Lord Janet M., Phillips Anna C., Cabana François, Larbi Anis, Dupuis Gilles, Fülöp Tamàs, Altered neutrophil functions in elderly patients during a 6-month follow-up period after a hip fracture, Experimental Gerontology, 65, 2015. Crossref

  10. Saavedra Danay, García Beatriz, Lorenzo-Luaces Patricia, González Amnely, Popa Xitlally, Fuentes Karla P., Mazorra Zaima, Crombet Tania, Neninger Elia, Lage Agustin, Biomarkers related to immunosenescence: relationships with therapy and survival in lung cancer patients, Cancer Immunology, Immunotherapy, 65, 1, 2016. Crossref

  11. Cho Si-Young, Kim Juewon, Lee Ji Hae, Sim Ji Hyun, Cho Dong-Hyun, Bae Il-Hong, Lee Hyunbok, Seol Min A., Shin Hyun Mu, Kim Tae-Joo, Kim Dae-Yong, Lee Su-Hyung, Shin Song Seok, Im Sin-Hyeog, Kim Hang-Rae, Modulation of gut microbiota and delayed immunosenescence as a result of syringaresinol consumption in middle-aged mice, Scientific Reports, 6, 1, 2016. Crossref

  12. Battle-Lopez Ana, Gonzalez de Villambrosia Sonia, Nuñez Javier, Cagigal Maria-Luisa, Montes-Moreno Santiago, Conde Eulogio, Piris Miguel A, Epstein-Barr virus-associated diffuse large B-cell lymphoma: diagnosis, difficulties and therapeutic options, Expert Review of Anticancer Therapy, 16, 4, 2016. Crossref

  13. Gonzalez O.A., Kirakodu S., Novak M.J., Stromberg A.J., Orraca L., Gonzalez-Martinez J., Burgos A., Ebersole J.L., Comparative analysis of microbial sensing molecules in mucosal tissues with aging, Immunobiology, 223, 3, 2018. Crossref

  14. Krenzien Felix, El Hajj Sandra, Tullius Stefan G., Gabardi Steven, Immunosenescence and Immunosuppressive Drugs in the Elderly, in Handbook of Immunosenescence, 2018. Crossref

  15. Fedarko Neal S., Theories and Mechanisms of Aging, in Geriatric Anesthesiology, 2018. Crossref

  16. Hassouneh Fakhri, Lopez-Sejas Nelson, Campos Carmen, Sanchez-Correa Beatriz, Tarazona Raquel, Solana Rafael, Pera Alejandra, Differential Effect of Cytomegalovirus Infection with Age on the Expression of CD57, CD300a, and CD161 on T-Cell Subpopulations, Frontiers in Immunology, 8, 2017. Crossref

  17. Hassouneh Fakhri, Lopez-Sejas Nelson, Campos Carmen, Sanchez-Correa Beatriz, Tarazona Raquel, Pera Alejandra, Solana Rafael, Effect of Cytomegalovirus (CMV) and Ageing on T-Bet and Eomes Expression on T-Cell Subsets, International Journal of Molecular Sciences, 18, 7, 2017. Crossref

  18. Friedman Claire F., Wolchok Jedd D., Checkpoint inhibition and melanoma: Considerations in treating the older adult, Journal of Geriatric Oncology, 8, 4, 2017. Crossref

  19. Jose Shyam Sushama, Bendickova Kamila, Kepak Tomas, Krenova Zdenka, Fric Jan, Chronic Inflammation in Immune Aging: Role of Pattern Recognition Receptor Crosstalk with the Telomere Complex?, Frontiers in Immunology, 8, 2017. Crossref

  20. Goubran Hadi A., Kotb Rami R., Stakiw Julie, Emara Mohamed E., Burnouf Thierry, Regulation of Tumor Growth and Metastasis: The Role of Tumor Microenvironment, Cancer Growth and Metastasis, 7, 2014. Crossref

  21. Falandry Claire, Sarkozy Clémentine, Salles Gilles, The Biologic Interconnections Between Aging and Lymphoma, in Geriatric Oncology, 2018. Crossref

  22. Foster Jared C., Le-Rademacher Jennifer G., Feliciano Josephine L., Gajra Ajeet, Seisler Drew K., DeMatteo Ronald, Lafky Jacqueline M., Hurria Arti, Muss Hyman B., Cohen Harvey J., Jatoi Aminah, Comparative “nocebo effects” in older patients enrolled in cancer therapeutic trials: Observations from a 446-patient cohort, Cancer, 123, 21, 2017. Crossref

  23. Pilkington Suzanne M., Ogden Stephanie, Eaton Laura H., Dearman Rebecca J., Kimber Ian, Griffiths Christopher E. M., Lower levels of interleukin-1β gene expression are associated with impaired Langerhans’ cell migration in aged human skin, Immunology, 153, 1, 2018. Crossref

  24. Bhandari Shruti, Gill Amitoj S, Perez Cesar A, Jain Dharamvir, Management of immunotherapy toxicities in older adults, Seminars in Oncology, 45, 4, 2018. Crossref

  25. Campos Carmen, Pera Alejandra, Pita-Lopez M. L., Lopez-Cejas Nelson, Hassouneh Fakhri, Sánchez-Correa Beatriz, Gayoso Inmaculada, Alonso Corona, Peralbo Esther, Casado Javier G., Morgado Sara, Tarazona Raquel, Solana Rafael, Natural Killer Cells in Human Aging, in Handbook of Immunosenescence, 2018. Crossref

  26. Witkowski Jacek M., Fulop Tamas, T-Cell Cycle and Immunosenescence: Role of Aging in the T-Cell Proliferative Behavior and Status Quo Maintenance, in Handbook of Immunosenescence, 2019. Crossref

  27. Egorov Evgeny S., Kasatskaya Sofya A., Zubov Vasiliy N., Izraelson Mark, Nakonechnaya Tatiana O., Staroverov Dmitriy B., Angius Andrea, Cucca Francesco, Mamedov Ilgar Z., Rosati Elisa, Franke Andre, Shugay Mikhail, Pogorelyy Mikhail V., Chudakov Dmitriy M., Britanova Olga V., The Changing Landscape of Naive T Cell Receptor Repertoire With Human Aging, Frontiers in Immunology, 9, 2018. Crossref

  28. Palladini Arianna, Landuzzi Lorena, Lollini Pier-Luigi, Nanni Patrizia, Cancer immunoprevention: from mice to early clinical trials, BMC Immunology, 19, 1, 2018. Crossref

  29. Fülöp Tamas, Pawelec Graham, Witkowski Jacek M., Cohen Alan A., Fortin Carl, Le Page Aurelie, Garneau Hugo, Dupuis Gilles, Larbi Anis, Immunological Methods and the Concept of Inflammaging in the Study of Human Aging, in Conn's Handbook of Models for Human Aging, 2018. Crossref

  30. Pilkington S.M., Barron M.J., Watson R.E.B., Griffiths C.E.M., Bulfone‐Paus S., Aged human skin accumulates mast cells with altered functionality that localize to macrophages and vasoactive intestinal peptide‐positive nerve fibres, British Journal of Dermatology, 180, 4, 2019. Crossref

  31. Mancuso Salvatrice, Carlisi Melania, Santoro Marco, Napolitano Mariasanta, Raso Simona, Siragusa Sergio, Immunosenescence and lymphomagenesis, Immunity & Ageing, 15, 1, 2018. Crossref

  32. Campos Carmen, Pera Alejandra, Pita-López María Luisa, Lopez-Sejas Nelson, Hassouneh Fakhri, Sánchez-Correa Beatriz, Gayoso Inmaculada, Alonso Corona, Peralbo Esther, Casado Javier G., Morgado Sara, Tarazona Raquel, Solana Rafael, Natural Killer Cells in Human Aging, in Handbook of Immunosenescence, 2019. Crossref

  33. Witkowski Jacek M., Fulop Tamas, T Cell Cycle and Immunosenescence: Role of Aging in the T Cell Proliferative Behavior and Status Quo Maintenance, in Handbook of Immunosenescence, 2019. Crossref

  34. Simm Andreas, Seliger Barbara, Klotz Lars-Oliver, Cellular Aging and Tumor Regulation, in Cellular Ageing and Replicative Senescence, 2016. Crossref

  35. Krenzien Felix, El Hajj Sandra, Tullius Stefan G., Gabardi Steven, Immunosenescence and Immunosuppressive Drugs in the Elderly, in Handbook of Immunosenescence, 2019. Crossref

  36. Fulop Tamàs, Witkowski Jacek M., Cohen Alan A., Dupuis Gilles, Hirokawa Katsuiku, Larbi Anis, From Inflamm-Aging to Immunosenescence, in The Cambridge Handbook of Successful Aging, 2019. Crossref

  37. Leiting Jennifer L., Hernandez Matthew C., Yang Lin, Bergquist John R., Ivanics Tommy, Graham Rondell P., Truty Mark J., Rituximab Decreases Lymphoproliferative Tumor Formation in Hepatopancreaticobiliary and Gastrointestinal Cancer Patient-Derived Xenografts, Scientific Reports, 9, 1, 2019. Crossref

  38. Lemaître Jean‐François, Pavard Samuel, Giraudeau Mathieu, Vincze Orsolya, Jennings Geordie, Hamede Rodrigo, Ujvari Beata, Thomas Frédéric, Fox Charles, Eco‐evolutionary perspectives of the dynamic relationships linking senescence and cancer, Functional Ecology, 34, 1, 2020. Crossref

  39. Fulop Tamas, Cohen Alan, Wong Glenn, Witkowski Jacek M., Larbi Anis, Are There Reliable Biomarkers for Immunosenescence and Inflammaging?, in Biomarkers of Human Aging, 10, 2019. Crossref

  40. Vitale Ilio, Sistigu Antonella, Manic Gwenola, Rudqvist Nils-Petter, Trajanoski Zlatko, Galluzzi Lorenzo, Mutational and Antigenic Landscape in Tumor Progression and Cancer Immunotherapy, Trends in Cell Biology, 29, 5, 2019. Crossref

  41. Navani Vishal, Graves Moira C., Bowden Nikola A., Van Der Westhuizen Andre, Immune checkpoint blockade in solid organ tumours: Choice, dose and predictors of response, British Journal of Clinical Pharmacology, 86, 9, 2020. Crossref

  42. Beltran Brady E., Castro Denisse, Paredes Sally, Miranda Roberto N., Castillo Jorge J., EBV‐positive diffuse large B‐cell lymphoma, not otherwise specified: 2020 update on diagnosis, risk‐stratification and management, American Journal of Hematology, 95, 4, 2020. Crossref

  43. Shannon Adrienne B., Song Yun, Xu Xiaowei, Karakousis Giorgos C., Age and Melanocytic Lesions, Surgical Oncology Clinics of North America, 29, 3, 2020. Crossref

  44. Marconcini Riccardo, Spagnolo Francesco, Stucci Luigia Stefania, Ribero Simone, Marra Elena, De Rosa Francesco, Picasso Virginia, Di Guardo Lorenza, Cimminiello Carolina, Cavalieri Stefano, Orgiano Laura, Tanda Enrica, Spano Laura, Falcone Alfredo, Queirolo Paola, Current status and perspectives in immunotherapy for metastatic melanoma, Oncotarget, 9, 15, 2018. Crossref

  45. Witkowski Jacek M., Bryl Ewa, Fulop Tamas, Should we Try to Alleviate Immunosenescence and Inflammaging - Why, How and to What Extent?, Current Pharmaceutical Design, 25, 39, 2019. Crossref

  46. Houdek Matthew T., Witten Brent G., Hevesi Mario, Griffin Anthony M., Salduz Ahmet, Wenger Doris E., Sim Franklin H., Ferguson Peter C., Rose Peter S., Wunder Jay S., Advancing patient age is associated with worse outcomes in low‐ and intermediate‐grade primary chondrosarcoma of the pelvis, Journal of Surgical Oncology, 121, 4, 2020. Crossref

  47. Schulz Gerald Bastian, Rodler Severin, Szabados Bernadett, Graser Annabel, Buchner Alexander, Stief Christian, Casuscelli Jozefina, Safety, efficacy and prognostic impact of immune checkpoint inhibitors in older patients with genitourinary cancers, Journal of Geriatric Oncology, 11, 7, 2020. Crossref

  48. Falandry Claire, Sarkozy Clémentine, Salles Gilles, The Biologic Interconnections Between Aging and Lymphoma, in Geriatric Oncology, 2020. Crossref

  49. Blagosklonny Mikhail, Gudkov Andrei, Introducing, OncoTarget, Oncotarget, 1, 1, 2010. Crossref

  50. Lisanti Camilla, Basile Debora, Parnofiello Annamaria, Bertoli Elisa, Andreotti Victoria Josephine, Garattini Silvio Ken, Bartoletti Michele, Cattaneo Monica, Di Nardo Paola, Bonotto Marta, Casagrande Mariaelena, Da Ros Lucia, Cinausero Marika, Foltran Luisa, Pella Nicoletta, Buonadonna Angela, Aprile Giuseppe, Fasola Gianpiero, Puglisi Fabio, The SENECA study: Prognostic role of serum biomarkers in older patients with metastatic colorectal cancer, Journal of Geriatric Oncology, 11, 8, 2020. Crossref

  51. Morita Yuji, Jounai Kenta, Sakamoto Akihiko, Tomita Yasuyuki, Sugihara Yoshihiko, Suzuki Hiroaki, Ohshio Konomi, Otake Masato, Fujiwara Daisuke, Kanauchi Osamu, Maruyama Mitsuo, Long-term intake of Lactobacillus paracasei KW3110 prevents age-related chronic inflammation and retinal cell loss in physiologically aged mice, Aging, 10, 10, 2018. Crossref

  52. Montaudié Henri, Tumors: Melanoma, in Encyclopedia of Gerontology and Population Aging, 2020. Crossref

  53. Lázničková Petra, Bendíčková Kamila, Kepák Tomáš, Frič Jan, Immunosenescence in Childhood Cancer Survivors and in Elderly: A Comparison and Implication for Risk Stratification, Frontiers in Aging, 2, 2021. Crossref

  54. Libertini Giacinto, Corbi Graziamaria, Conti Valeria, Shubernetskaya Olga, Ferrara Nicola, Subtelomere-Telomere Aging Theory, in Evolutionary Gerontology and Geriatrics, 2, 2021. Crossref

  55. Morita Yuji, Jounai Kenta, Tomita Yasuyuki, Maruyama Mitsuo, Long-term intake of Lactobacillus paracasei KW3110 prevents age-related circadian locomotor activity and changes in gut metabolism in physiologically aged mice, Experimental Gerontology, 153, 2021. Crossref

  56. Montaudié Henri, Tumors: Melanoma, in Encyclopedia of Gerontology and Population Aging, 2021. Crossref

  57. Bigas Anna, Rodriguez-Sevilla Juan José, Espinosa Lluis, Gallardo Fernando, Recent advances in T-cell lymphoid neoplasms, Experimental Hematology, 106, 2022. Crossref

  58. Langsford David, Steinberg Adam, Dwyer Karen M., Diabetes Mellitus Following Renal Transplantation: Clinical and Pharmacological Considerations for the Elderly Patient, Drugs & Aging, 34, 8, 2017. Crossref

  59. Frankowska Natalia, Lisowska Katarzyna, Witkowski Jacek M., Proteolysis dysfunction in the process of aging and age-related diseases, Frontiers in Aging, 3, 2022. Crossref

  60. Fulop Tamas, Witkowski Jacek M., Olivieri Fabiola, Larbi Anis, The integration of inflammaging in age-related diseases, Seminars in Immunology, 40, 2018. Crossref

  61. Martin Austin, Woolbright Benjamin L., Umar Shahid, Ingersoll Molly A., Taylor John A., Bladder cancer, inflammageing and microbiomes, Nature Reviews Urology, 19, 8, 2022. Crossref

  62. Jinna Nikita, Rida Padmashree, Su Tianyi, Gong Zhihong, Yao Song, LaBarge Mark, Natarajan Rama, Jovanovic-Talisman Tijana, Ambrosone Christine, Seewaldt Victoria, The DARC Side of Inflamm-Aging: Duffy Antigen Receptor for Chemokines (DARC/ACKR1) as a Potential Biomarker of Aging, Immunosenescence, and Breast Oncogenesis among High-Risk Subpopulations, Cells, 11, 23, 2022. Crossref

Портал Begell Электронная Бибилиотека e-Книги Журналы Справочники и Сборники статей Коллекции Цены и условия подписки Begell House Контакты Language English 中文 Русский Português German French Spain