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Critical Reviews™ in Oncogenesis
Главный редактор: Benjamin Bonavida (open in a new tab)

Выходит 4 номеров в год

ISSN Печать: 0893-9675

ISSN Онлайн: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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Ras Suppressor-1 (RSU-1) in Cancer Cell Metastasis: Friend or Foe?

Том 22, Выпуск 3-4, 2017, pp. 249-253
DOI: 10.1615/CritRevOncog.2018024231
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Краткое описание

Metastasis to distant organs and not the primary tumor itself is usually the cause of death for cancer patients. Hence, studying the key molecules and molecular pathways involved in metastasis are essential. Metastasis is a complex process in which cancer cells detach from the original tumor, migrate, and invade through surrounding tissues and metastasize to other sites of the body through the circulation. The cell-extracellular matrix (ECM) adhesion proteins play a fundamental role in this process as cancer cells need to weaken their adhesions to dissociate from the ECM as well as the neighboring cells within the tumor and finally form new adhesions and invade surrounding tissues. Ras suppressor-1 (RSU-1) was originally identified as a suppressor of Ras-dependent oncogenic transformation and found to be localized to cell-ECM adhesions where it binds to PINCH-1, a focal adhesion involved in cell survival. Although RSU-1 was connected to cancer early on, little is known about its expression in various cancer types or its role in metastasis. In this article, we review the recent literature regarding the expression of RSU-1 in various cancer types and its potential role in metastasis, discussing interesting findings and issues that still need to be addressed.

ЦИТИРОВАНО В
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  2. Louca Maria, Gkretsi Vasiliki, Stylianopoulos Triantafyllos, Coordinated Expression of Ras Suppressor 1 (RSU-1) and Growth Differentiation Factor 15 (GDF15) Affects Glioma Cell Invasion, Cancers, 11, 8, 2019. Crossref

  3. Louca Maria, Stylianou Andreas, Minia Angeliki, Pliaka Vaia, Alexopoulos Leonidas G., Gkretsi Vasiliki, Stylianopoulos Triantafyllos, Ras suppressor-1 (RSU-1) promotes cell invasion in aggressive glioma cells and inhibits it in non-aggressive cells through STAT6 phospho-regulation, Scientific Reports, 9, 1, 2019. Crossref

  4. Louca Maria, Stylianopoulos Triantafyllos, Gkretsi Vasiliki, Ras Suppressor-1 (RSU1) in Cancer Cell Metastasis: A Tale of a Tumor Suppressor, International Journal of Molecular Sciences, 21, 11, 2020. Crossref

  5. Nikou Sofia, Arbi Marina, Dimitrakopoulos Foteinos-Ioannis D., Sirinian Chaido, Chadla Panagiota, Pappa Ioanna, Ntaliarda Giannoula, Stathopoulos Georgios T., Papadaki Helen, Zolota Vasiliki, Lygerou Zoi, Kalofonos Haralabos P., Bravou Vasiliki, Integrin-linked kinase (ILK) regulates KRAS, IPP complex and Ras suppressor-1 (RSU1) promoting lung adenocarcinoma progression and poor survival, Journal of Molecular Histology, 51, 4, 2020. Crossref

  6. Wang Zhonghai, Zhang Wenmin, Fang Jinchuan, Xie Ping, Miao Miao, Yang Hongwen, <p>Circular RNA circEXOC6B Inhibits the Progression of Ovarian Cancer by Sponging miR-421 and Regulating RUS1 Expression</p>, OncoTargets and Therapy, Volume 13, 2020. Crossref

  7. Yang Haibin, Lin Leishu, Sun Kang, Zhang Ting, Chen Wan, Li Lianghui, Xie Yuchen, Wu Chuanyue, Wei Zhiyi, Yu Cong, Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics, eLife, 10, 2021. Crossref

  8. Rivello Francesca, Matuła Kinga, Piruska Aigars, Smits Minke, Mehra Niven, Huck Wilhelm T. S., Probing single-cell metabolism reveals prognostic value of highly metabolically active circulating stromal cells in prostate cancer, Science Advances, 6, 40, 2020. Crossref

  9. Geramoutsou Christina, Nikou Sofia, Karavias Dimitrios, Arbi Marina, Tavlas Panagiotis, Tzelepi Vasiliki, Lygerou Zoi, Maroulis Ioannis, Bravou Vasiliki, Focal adhesion proteins in hepatocellular carcinoma: RSU1 a novel tumour suppressor with prognostic significance, Pathology - Research and Practice, 235, 2022. Crossref

  10. Nikou Sofia, Arbi Marina, Dimitrakopoulos Foteinos-Ioannis D., Kalogeropoulou Argiro, Geramoutsou Christina, Zolota Vasiliki, Kalofonos Haralabos P., Taraviras Stavros, Lygerou Zoi, Bravou Vasiliki, Ras suppressor-1 (RSU1) exerts a tumor suppressive role with prognostic significance in lung adenocarcinoma, Clinical and Experimental Medicine, 2022. Crossref

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