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Critical Reviews™ in Biomedical Engineering

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ISSN Печать: 0278-940X

ISSN Онлайн: 1943-619X

SJR: 0.262 SNIP: 0.372 CiteScore™:: 2.2 H-Index: 56

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Biomedical Engineering Strategies for Peripheral Nerve Repair: Surgical Applications, State of the Art, and Future Challenges

Том 39, Выпуск 2, 2011, pp. 81-124
DOI: 10.1615/CritRevBiomedEng.v39.i2.20
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Краткое описание

Damage to the peripheral nervous system is surprisingly common and occurs primarily from trauma or a complication of surgery. Although recovery of nerve function occurs in many mild injuries, outcomes are often unsatisfactory following severe trauma. Nerve repair and regeneration presents unique clinical challenges and opportunities, and substantial contributions can be made through the informed application of biomedical engineering strategies. This article reviews the clinical presentations and classification of nerve injuries, in addition to the state of the art for surgical decision-making and repair strategies. This discussion presents specific challenges that must be addressed to realistically improve the treatment of nerve injuries and promote widespread recovery. In particular, nerve defects a few centimeters in length use a sensory nerve autograft as the standard technique; however, this approach is limited by the availability of donor nerve and comorbidity associated with additional surgery. Moreover, we currently have an inadequate ability to noninvasively assess the degree of nerve injury and to track axonal regeneration. As a result, wait-and-see surgical decisions can lead to undesirable and less successful "delayed" repair procedures. In this fight for time, degeneration of the distal nerve support structure and target progresses, ultimately blunting complete functional recovery. Thus, the most pressing challenges in peripheral nerve repair include the development of tissue-engineered nerve grafts that match or exceed the performance of autografts, the ability to noninvasively assess nerve damage and track axonal regeneration, and approaches to maintain the efficacy of the distal pathway and targets during the regenerative process. Biomedical engineering strategies can address these issues to substantially contribute at both the basic and applied levels, improving surgical management and functional recovery following severe peripheral nerve injury.

ЦИТИРОВАНО В
  1. Szynkaruk Mark, Kemp Stephen W.P., Wood Matthew D., Gordon Tessa, Borschel Gregory H., Experimental and Clinical Evidence for Use of Decellularized Nerve Allografts in Peripheral Nerve Gap Reconstruction, Tissue Engineering Part B: Reviews, 19, 1, 2013. Crossref

  2. Mokarram Nassir, Merchant Alishah, Mukhatyar Vivek, Patel Gaurangkumar, Bellamkonda Ravi V., Effect of modulating macrophage phenotype on peripheral nerve repair, Biomaterials, 33, 34, 2012. Crossref

  3. Zhou Wenda, Blewitt Matthew, Hobgood Ashley, Willits Rebecca Kuntz, Comparison of neurite growth in three dimensional natural and synthetic hydrogels, Journal of Biomaterials Science, Polymer Edition, 24, 3, 2013. Crossref

  4. Mendes Raquel Metzker, Barbosa Rafael Inácio, Salmón Carlos Ernesto Garrido, Rondinoni Carlo, Escorsi-Rosset Sara, Delsim Juliana Carla, Barbieri Cláudio Henrique, Mazzer Nilton, Auditory stimuli from a sensor glove model modulate cortical audiotactile integration, Neuroscience Letters, 548, 2013. Crossref

  5. Johnson P. J., Wood M. D., Moore A. M ., Mackinnon S. E., Tissue engineered constructs for peripheral nerve surgery, European Surgery, 45, 3, 2013. Crossref

  6. Sedaghati Tina, Jell Gavin, Seifalian Alexander M., Nerve Regeneration and Bioengineering, in Regenerative Medicine Applications in Organ Transplantation, 2014. Crossref

  7. Vasudevan Srikanth, Yan Ji-Geng, Zhang Lin-Ling, Matloub Hani S., Cheng Jonathan J., A Rat Model for Long-Gap Peripheral Nerve Reconstruction, Plastic and Reconstructive Surgery, 132, 4, 2013. Crossref

  8. Geuna Stefano, Gnavi Sara, Perroteau Isabelle, Tos Pierluigi, Battiston Bruno, Tissue Engineering and Peripheral Nerve Reconstruction, in Tissue Engineering of the Peripheral Nerve: Stem Cells and Regeneration Promoting Factors, 108, 2013. Crossref

  9. Tos Pierluigi, Ronchi Giulia, Geuna Stefano, Battiston Bruno, Future Perspectives in Nerve Repair and Regeneration, in Tissue Engineering of the Peripheral Nerve - Biomaterials and physical therapy, 109, 2013. Crossref

  10. Katchinskiy Nir, Godbout Roseline, Goez Helly R., Elezzabi Abdulhakem Y., Femtosecond laser-induced cell-cell surgical attachment, Lasers in Surgery and Medicine, 46, 4, 2014. Crossref

  11. Shim Sun Woo, Kwon Doo Yeon, Lee Bit Na, Kwon Jin Seon, Park Ji Hoon, Lee Jun Hee, Kim Jae Ho, Lee Il Woo, Shin Jung-Woog, Lee Hai Bang, Kim Wan-Doo, Kim Moon Suk, Evaluation of Small Intestine Submucosa and Poly(caprolactone-co-lactide) Conduits for Peripheral Nerve Regeneration, Tissue Engineering Part A, 21, 5-6, 2015. Crossref

  12. Hoyng Stefan A., De Winter Fred, Gnavi Sara, de Boer Ralph, Boon Lennard I., Korvers Laura M., Tannemaat Martijn R., Malessy Martijn J.A., Verhaagen Joost, A comparative morphological, electrophysiological and functional analysis of axon regeneration through peripheral nerve autografts genetically modified to overexpress BDNF, CNTF, GDNF, NGF, NT3 or VEGF, Experimental Neurology, 261, 2014. Crossref

  13. Struzyna Laura A., Katiyar Kritika, Cullen D. Kacy, Living scaffolds for neuroregeneration, Current Opinion in Solid State and Materials Science, 18, 6, 2014. Crossref

  14. Gordon Tessa, Neurotrophic factor expression in denervated motor and sensory Schwann cells: Relevance to specificity of peripheral nerve regeneration, Experimental Neurology, 254, 2014. Crossref

  15. Grinsell D., Keating C. P., Peripheral Nerve Reconstruction after Injury: A Review of Clinical and Experimental Therapies, BioMed Research International, 2014, 2014. Crossref

  16. Markiewicz Katarzyna, van Til Janine A., IJzerman Maarten J., MEDICAL DEVICES EARLY ASSESSMENT METHODS: SYSTEMATIC LITERATURE REVIEW, International Journal of Technology Assessment in Health Care, 30, 2, 2014. Crossref

  17. Kou Yuhui, Wang Zhiyong, Wu Zhihong, Zhang Peixun, Zhang Yu, Yin Xiaofeng, Wong Xisheng, Qiu Guixing, Jiang Baoguo, EpimediumExtract Promotes Peripheral Nerve Regeneration in Rats, Evidence-Based Complementary and Alternative Medicine, 2013, 2013. Crossref

  18. Sachanandani Neil F., Pothula Aravind, Tung Thomas H., Nerve Gaps, Plastic and Reconstructive Surgery, 133, 2, 2014. Crossref

  19. Vasudevan Srikanth, Huang Jiying, Botterman Barry, Matloub Hani S., Keefer Edward, Cheng Jonathan, Detergent-free Decellularized Nerve Grafts for Long-gap Peripheral Nerve Reconstruction, Plastic and Reconstructive Surgery Global Open, 2, 8, 2014. Crossref

  20. Gustafson Tiffany P., Yan Ying, Newton Piyaraj, Hunter Daniel A., Achilefu Samuel, Akers Walter J., Mackinnon Susan E., Johnson Philip J., Berezin Mikhail Y., A NIR dye for development of peripheral nerve targeted probes, MedChemComm, 3, 6, 2012. Crossref

  21. Nune Manasa, Krishnan Uma Maheswari, Sethuraman Swaminathan, Decoration of PLGA electrospun nanofibers with designer self-assembling peptides: a “Nano-on-Nano” concept, RSC Advances, 5, 108, 2015. Crossref

  22. Sugimura-Wakayama Yukiko, Katagiri Wataru, Osugi Masashi, Kawai Takamasa, Ogata Kenichi, Sakaguchi Kohei, Hibi Hideharu, Peripheral Nerve Regeneration by Secretomes of Stem Cells from Human Exfoliated Deciduous Teeth, Stem Cells and Development, 24, 22, 2015. Crossref

  23. Koppes A.N., Thompson D.M., Neural innervation of engineered musculoskeletal tissues, in Regenerative Engineering of Musculoskeletal Tissues and Interfaces, 2015. Crossref

  24. Tian Feng, Ji Xiang-lu, Xiao Wan-an, Wang Bin, Wang Fei, WITHDRAWN: Macrophage-derived microvesicles promote proliferation and migration of Schwann cells on peripheral nerve repair, Biomedicine & Pharmacotherapy, 2015. Crossref

  25. Gordon Tessa, The Biology, Limits, and Promotion of Peripheral Nerve Regeneration in Rats and Humans, in Nerves and Nerve Injuries, 2015. Crossref

  26. Zhan Chuan, Ma Cheng-bin, Yuan Hong-mou, Cao Bao-yuan, Zhu Jia-jun, Macrophage-derived microvesicles promote proliferation and migration of Schwann cell on peripheral nerve repair, Biochemical and Biophysical Research Communications, 468, 1-2, 2015. Crossref

  27. Johnson Blake N., Lancaster Karen Z., Zhen Gehua, He Junyun, Gupta Maneesh K., Kong Yong Lin, Engel Esteban A., Krick Kellin D., Ju Alex, Meng Fanben, Enquist Lynn W., Jia Xiaofeng, McAlpine Michael C., 3D Printed Anatomical Nerve Regeneration Pathways, Advanced Functional Materials, 25, 39, 2015. Crossref

  28. Koppes Ryan A., Park Seongjun, Hood Tiffany, Jia Xiaoting, Abdolrahim Poorheravi Negin, Achyuta Anilkumar Harapanahalli, Fink Yoel, Anikeeva Polina, Thermally drawn fibers as nerve guidance scaffolds, Biomaterials, 81, 2016. Crossref

  29. Mikhailov Andrey, Saotome Kousaku, Matsushita Akira, Sankai Yoshiyuki, Multifunctional chitosan implants for controllable protein release, 2013 6th International IEEE/EMBS Conference on Neural Engineering (NER), 2013. Crossref

  30. Paprottka Felix J., Wolf Petra, Harder Yves, Kern Yasmin, Paprottka Philipp M., Machens Hans-Günther, Lohmeyer Jörn A., Sensory Recovery Outcome after Digital Nerve Repair in Relation to Different Reconstructive Techniques: Meta-Analysis and Systematic Review, Plastic Surgery International, 2013, 2013. Crossref

  31. Hopkins Tracy M., Heilman Alexander M., Liggett James A., LaSance Kathleen, Little Kevin J., Hom David B., Minteer Danielle M., Marra Kacey G., Pixley Sarah K., Combining micro-computed tomography with histology to analyze biomedical implants for peripheral nerve repair, Journal of Neuroscience Methods, 255, 2015. Crossref

  32. Baddour Joëlle A., Sousounis Konstantinos, Tsonis Panagiotis A., Organ repair and regeneration: An overview, Birth Defects Research Part C: Embryo Today: Reviews, 96, 1, 2012. Crossref

  33. Luo Lihua, Gan Li, Liu Yongming, Tian Weiqun, Tong Zan, Wang Xiong, Huselstein Celine, Chen Yun, Construction of nerve guide conduits from cellulose/soy protein composite membranes combined with Schwann cells and pyrroloquinoline quinone for the repair of peripheral nerve defect, Biochemical and Biophysical Research Communications, 457, 4, 2015. Crossref

  34. Bai Lu, Wang Tian-bing, Wang Xin, Zhang Wei-wen, Xu Ji-hai, Cai Xiao-ming, Zhou Dan-ya, Cai Li-bing, Pan Jia-dong, Tian Min-tao, Chen Hong, Zhang Dian-ying, Fu Zhong-guo, Zhang Pei-xun, Jiang Bao-guo, Use of nerve elongator to repair short-distance peripheral nerve defects: a prospective randomized study, Neural Regeneration Research, 10, 1, 2015. Crossref

  35. Loverde J. R., Pfister B. J., High magnification imaging of neuronal somata undergoing Axon Stretch Growth in vitro, 2012 38th Annual Northeast Bioengineering Conference (NEBEC), 2012. Crossref

  36. Struzyna LauraA, Harris JamesP, Katiyar KritikaS, Chen HIsaac, Cullen DKacy, Restoring nervous system structure and function using tissue engineered living scaffolds, Neural Regeneration Research, 10, 5, 2015. Crossref

  37. Nawrotek Katarzyna, Tylman Michał, Rudnicka Karolina, Balcerzak Jacek, Kamiński Kamil, Chitosan-based hydrogel implants enriched with calcium ions intended for peripheral nervous tissue regeneration, Carbohydrate Polymers, 136, 2016. Crossref

  38. Loverde Joseph R., Ozoka Vivian C., Aquino Robert, Lin Ling, Pfister Bryan J., Live Imaging of Axon Stretch Growth in Embryonic and Adult Neurons, Journal of Neurotrauma, 28, 11, 2011. Crossref

  39. Zilic Leyla, Wilshaw Stacy‐Paul, Haycock John W., Decellularisation and histological characterisation of porcine peripheral nerves, Biotechnology and Bioengineering, 113, 9, 2016. Crossref

  40. Oliveira Júlia Teixeira, de Oliveira Goulart Camila, de Lima Silmara Veline Souto, Mendonça Henrique Rocha, de Andrade Klauss Mostacada, Baptista Abrahão Fontes, Martinez Ana Maria Blanco, Peripheral Nervous System: Regenerative Therapies, in Regenerative Medicine - from Protocol to Patient, 2016. Crossref

  41. Vishnoi Tanushree, Kumar Ashok, Cryogels for Neural Tissue Engineering, in Supermacroporous Cryogels, 2016. Crossref

  42. Padilla Sabino, Sánchez Mikel, Orive Gorka, Anitua Eduardo, Human-Based Biological and Biomimetic Autologous Therapies for Musculoskeletal Tissue Regeneration, Trends in Biotechnology, 35, 3, 2017. Crossref

  43. Grosso Clara, Valentão Patrícia, Ferreres Federico, Andrade Paula, Bioactive Marine Drugs and Marine Biomaterials for Brain Diseases, Marine Drugs, 12, 5, 2014. Crossref

  44. Zhu Qian, Lu Qiqi, Gao Rong, Cao Tong, Prospect of Human Pluripotent Stem Cell-Derived Neural Crest Stem Cells in Clinical Application, Stem Cells International, 2016, 2016. Crossref

  45. Caseiro Ana Rita, Pereira Tiago, Ivanova Galya, Luís Ana Lúcia, Maurício Ana Colette, Neuromuscular Regeneration: Perspective on the Application of Mesenchymal Stem Cells and Their Secretion Products, Stem Cells International, 2016, 2016. Crossref

  46. Takayama Yuzo, Kida Yasuyuki S., Di Giovanni Simone, In Vitro Reconstruction of Neuronal Networks Derived from Human iPS Cells Using Microfabricated Devices, PLOS ONE, 11, 2, 2016. Crossref

  47. Yamanaka Toshiaki, Hosoi Hiroshi, Murai Takayuki, Kobayashi Takehiko, Inada Yuji, Nakamura Tatsuo, Simon Sidney Arthur, Regeneration of the Nerves in the Aerial Cavity with an Artificial Nerve Conduit -Reconstruction of Chorda Tympani Nerve Gaps-, PLoS ONE, 9, 4, 2014. Crossref

  48. Kemp Stephen W.P., Cederna Paul S., Midha Rajiv, Comparative outcome measures in peripheral regeneration studies, Experimental Neurology, 287, 2017. Crossref

  49. KleinJan Gijs, Buckle Tessa, van Willigen Danny, Oosterom Matthias, Spa Silvia, Kloosterboer Harmen, van Leeuwen Fijs, Fluorescent Lectins for Local in Vivo Visualization of Peripheral Nerves, Molecules, 19, 7, 2014. Crossref

  50. Petrov D., Katiyar K.S., Struzyna L.A., Harris J.P., Cullen D.K., Extracellular matrix-derived tissues for neurological applications, in Extracellular Matrix-derived Implants in Clinical Medicine, 2016. Crossref

  51. Gordon Tessa, Nerve regeneration in the peripheral and central nervous systems, The Journal of Physiology, 594, 13, 2016. Crossref

  52. Dayawansa Samantha, Wang Ernest W., Liu Weimin, Markman John D., Gelbard Harris A., Huang Jason H., Allotransplanted DRG neurons or Schwann cells affect functional recovery in a rodent model of sciatic nerve injury, Neurological Research, 36, 11, 2014. Crossref

  53. Choe Shawn, Bond Christopher W., Harrington Daniel A., Stupp Samuel I., McVary Kevin T., Podlasek Carol A., Peptide amphiphile nanofiber hydrogel delivery of sonic hedgehog protein to the cavernous nerve to promote regeneration and prevent erectile dysfunction, Nanomedicine: Nanotechnology, Biology and Medicine, 13, 1, 2017. Crossref

  54. Keilhoff Gerburg, Becker Axel, Kropf Siegfried, Schild Lorenz, Sciatic nerve ligation causes impairment of mitochondria associated with changes in distribution, respiration, and cardiolipin composition in related spinal cord neurons in rats, Molecular and Cellular Biochemistry, 421, 1-2, 2016. Crossref

  55. Žygelytė Emilija, Bernard Megan E., Tomlinson Joy E., Martin Matthew J., Terhorst Allegra, Bradford Harriet E., Lundquist Sarah A., Sledziona Michael, Cheetham Jonathan, RetroDISCO: Clearing technique to improve quantification of retrograde labeled motor neurons of intact mouse spinal cords, Journal of Neuroscience Methods, 271, 2016. Crossref

  56. Roberts S. E., Thibaudeau S., Burrell J. C., Zager E. L., Cullen D. K., Levin L. S., To reverse or not to reverse? A systematic review of autograft polarity on functional outcomes following peripheral nerve repair surgery, Microsurgery, 37, 2, 2017. Crossref

  57. Yi Jiling, Xiong Feng, Li Binbin, Chen Heping, Yin Yixia, Dai Honglian, Li Shipu, Degradation characteristics, cell viability and host tissue responses of PDLLA-based scaffold with PRGD and β-TCP nanoparticles incorporation, Regenerative Biomaterials, 3, 3, 2016. Crossref

  58. Zuo Wenpu, Xu Fuben, Zhang Kun, Zheng Li, Zhao Jinmin, Proliferation-enhancing effects of gastrodin on RSC96 Schwann cells by regulating ERK1/2 and PI3K signaling pathways, Biomedicine & Pharmacotherapy, 84, 2016. Crossref

  59. Sánchez Mikel, Anitua Eduardo, Delgado Diego, Sanchez Peio, Prado Roberto, Orive Gorka, Padilla Sabino, Platelet-rich plasma, a source of autologous growth factors and biomimetic scaffold for peripheral nerve regeneration, Expert Opinion on Biological Therapy, 17, 2, 2017. Crossref

  60. Tamaki Tetsuro, Hirata Maki, Soeda Shuichi, Nakajima Nobuyuki, Saito Kosuke, Nakazato Kenei, Okada Yoshinori, Hashimoto Hiroyuki, Uchiyama Yoshiyasu, Mochida Joji, Asakura Atsushi, Preferential and Comprehensive Reconstitution of Severely Damaged Sciatic Nerve Using Murine Skeletal Muscle-Derived Multipotent Stem Cells, PLoS ONE, 9, 3, 2014. Crossref

  61. Gordon Tessa, Borschel Gregory H., The use of the rat as a model for studying peripheral nerve regeneration and sprouting after complete and partial nerve injuries, Experimental Neurology, 287, 2017. Crossref

  62. Kohn C., Klemens J. M., Kascholke C., Murthy N. S., Kohn J., Brandenburger M., Hacker M. C., Dual-component collagenous peptide/reactive oligomer hydrogels as potential nerve guidance materials – from characterization to functionalization, Biomaterials Science, 4, 11, 2016. Crossref

  63. Vennemeyer JJ, Hopkins T, Hershcovitch M, Little KD, Hagen MC, Minteer D, Hom DB, Marra K, Pixley SK, Initial observations on using magnesium metal in peripheral nerve repair, Journal of Biomaterials Applications, 29, 8, 2015. Crossref

  64. Yao Min, Zhou Yi, Xue Chengbin, Ren Hechun, Wang Shengran, Zhu Hui, Gu Xingjian, Gu Xiaosong, Gu Jianhui, Repair of Rat Sciatic Nerve Defects by Using Allogeneic Bone Marrow Mononuclear Cells Combined with Chitosan/Silk Fibroin Scaffold, Cell Transplantation, 25, 5, 2016. Crossref

  65. Mekaj Agon, Mekaj Ymer, The Role of Pharmacological Agents in Nerve Regeneration after Peripheral Nerve Repair, in Peripheral Nerve Regeneration - From Surgery to New Therapeutic Approaches Including Biomaterials and Cell-Based Therapies Development, 2017. Crossref

  66. Modrak Max, Sundem Leigh, Elfar John, Erythropoietin enhanced recovery after peripheral nerve injury, Neural Regeneration Research, 12, 8, 2017. Crossref

  67. Yeh Chia-Wei, Wang Li-Wen, Wu Hsi-Chin, Hsieh Yi-Kong, Wang Jane, Chen Ming-Hong, Wang Tzu-Wei, Development of biomimetic micro-patterned device incorporated with neurotrophic gradient and supportive Schwann cells for the applications in neural tissue engineering, Biofabrication, 9, 1, 2017. Crossref

  68. Saito Kosuke, Tamaki Tetsuro, Hirata Maki, Hashimoto Hiroyuki, Nakazato Kenei, Nakajima Nobuyuki, Kazuno Akihito, Sakai Akihiro, Iida Masahiro, Okami Kenji, Asakura Atsushi, Reconstruction of Multiple Facial Nerve Branches Using Skeletal Muscle-Derived Multipotent Stem Cell Sheet-Pellet Transplantation, PLOS ONE, 10, 9, 2015. Crossref

  69. Wang Houlei, Wu Jingping, Zhang Xinchao, Ding Lei, Zeng Qingmin, Heregulin-1β Promotes the Synergistic Effect Between Allogenic Skin-Derived Precursor Differentiated Schwann Cells (SKP-SC) and Acellular Nerve Allograft (ANA) in Peripheral Nerve Regeneration Through Inhibiting Mir-21, Brazilian Archives of Biology and Technology, 59, 2016. Crossref

  70. Nguyen Lyly, Afshari Ashkan, Kelm Nathaniel D., Pollins Alonda C., Shack R. Bruce, Does Mark D., Thayer Wesley P., Bridging the Gap, Annals of Plastic Surgery, 78, 6S, 2017. Crossref

  71. Lu Ziyin, Jiang Guozheng, Chen Ying, Wang Jian, Muhammad Ishfaq, Zhang Ling, Wang Rui, Liu Fangping, Li Rui, Qian Feng, Li Jichang, Salidroside attenuates colistin-induced neurotoxicity in RSC96 Schwann cells through PI3K/Akt pathway, Chemico-Biological Interactions, 271, 2017. Crossref

  72. Busuttil Francesca, Rahim Ahad A., Phillips James B., Combining Gene and Stem Cell Therapy for Peripheral Nerve Tissue Engineering, Stem Cells and Development, 26, 4, 2017. Crossref

  73. Tamaki Tetsuro, Therapeutic capacities of human and mouse skeletal muscle-derived stem cells for a long gap peripheral nerve injury, Neural Regeneration Research, 12, 11, 2017. Crossref

  74. Chen Ming-Ming, Qin Jing, Chen Shu-Jian, Yao Le-Meng, Zhang Lu-Yong, Yin Zhi-Qi, Liao Hong, Quercetin promotes motor and sensory function recovery following sciatic nerve-crush injury in C57BL/6J mice, The Journal of Nutritional Biochemistry, 46, 2017. Crossref

  75. Tezcan Aysu Hayriye, Peripheral Nerve Injury and Current Treatment Strategies, in Peripheral Nerve Regeneration - From Surgery to New Therapeutic Approaches Including Biomaterials and Cell-Based Therapies Development, 2017. Crossref

  76. Tamaki Tetsuro, Hirata Maki, Nakajima Nobuyuki, Saito Kosuke, Hashimoto Hiroyuki, Soeda Shuichi, Uchiyama Yoshiyasu, Watanabe Masahiko, Asakura Atsushi, A Long-Gap Peripheral Nerve Injury Therapy Using Human Skeletal Muscle-Derived Stem Cells (Sk-SCs): An Achievement of Significant Morphological, Numerical and Functional Recovery, PLOS ONE, 11, 11, 2016. Crossref

  77. Xia Bin, Lv Yonggang, Dual-delivery of VEGF and NGF by emulsion electrospun nanofibrous scaffold for peripheral nerve regeneration, Materials Science and Engineering: C, 82, 2018. Crossref

  78. Chung Joo-Ryun, Choi Jong-Won, Fiorellini Joseph P., Hwang Kyung-Gyun, Park Chang-Joo, Effects of nerve cells and adhesion molecules on nerve conduit for peripheral nerve regeneration, Journal of Dental Anesthesia and Pain Medicine, 17, 3, 2017. Crossref

  79. Guarino V., Cirillo V., Ambrosio L., 6.18 Multicomponent Conduits for Peripheral Nerve Regeneration ☆, in Comprehensive Biomaterials II, 2017. Crossref

  80. Ullah Imran, Park Ju-Mi, Kang Young-Hoon, Byun June-Ho, Kim Dae-Geon, Kim Joo-Heon, Kang Dong-Ho, Rho Gyu-Jin, Park Bong-Wook, Transplantation of Human Dental Pulp-Derived Stem Cells or Differentiated Neuronal Cells from Human Dental Pulp-Derived Stem Cells Identically Enhances Regeneration of the Injured Peripheral Nerve, Stem Cells and Development, 26, 17, 2017. Crossref

  81. Tao Jie, Hu Yu, Wang Shujuan, Zhang Jiumeng, Liu Xuan, Gou Zhiyuan, Cheng Hao, Liu Qianqi, Zhang Qianqian, You Shenglan, Gou Maling, A 3D-engineered porous conduit for peripheral nerve repair, Scientific Reports, 7, 1, 2017. Crossref

  82. Willand Michael P., Nguyen May-Anh, Borschel Gregory H., Gordon Tessa, Electrical Stimulation to Promote Peripheral Nerve Regeneration, Neurorehabilitation and Neural Repair, 30, 5, 2016. Crossref

  83. Pedrosa Sílvia Santos, Caseiro Ana Rita, Santos José Domingos, Maurício Ana Colette, Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art, in Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications, 2017. Crossref

  84. Braga Silva J., Marchese G.M., Cauduro C.G., Debiasi M., Nerve conduits for treating peripheral nerve injuries: A systematic literature review, Hand Surgery and Rehabilitation, 36, 2, 2017. Crossref

  85. Palispis Winnie A., Gupta Ranjan, Surgical repair in humans after traumatic nerve injury provides limited functional neural regeneration in adults, Experimental Neurology, 290, 2017. Crossref

  86. Zuo Wenpu, Wu Huayu, Zhang Kun, Lv Peizhen, Xu Fuben, Jiang Weizhe, Zheng Li, Zhao Jinmin, Baicalin promotes the viability of Schwann cells in vitro by regulating neurotrophic factors, Experimental and Therapeutic Medicine, 14, 1, 2017. Crossref

  87. Pawelec K M, Koffler J, Shahriari D, Galvan A, Tuszynski M H, Sakamoto J, Microstructure and in vivo characterization of multi-channel nerve guidance scaffolds , Biomedical Materials, 13, 4, 2018. Crossref

  88. Romero-Ortega Mario, Peripheral Nerves, Anatomy and Physiology of, in Encyclopedia of Computational Neuroscience, 2014. Crossref

  89. Vijayavenkataraman Sanjairaj, Zhang Shuo, Thaharah Siti, Sriram Gopu, Lu Wen Feng, Fuh Jerry Ying Hsi, Electrohydrodynamic Jet 3D Printed Nerve Guide Conduits (NGCs) for Peripheral Nerve Injury Repair, Polymers, 10, 7, 2018. Crossref

  90. Rahman Saeed, Nagrath Malvika, Ponnusamy Sasikumar, Arany Praveen, Nanoscale and Macroscale Scaffolds with Controlled-Release Polymeric Systems for Dental Craniomaxillofacial Tissue Engineering, Materials, 11, 8, 2018. Crossref

  91. Visalli Carmela, Cavallaro Marco, Concerto Antonella, La Torre Domenico, Di Salvo Rosanna, Mazziotti Silvio, Salamone Ignazio, Ultrasonography of traumatic injuries to limb peripheral nerves: technical aspects and spectrum of features, Japanese Journal of Radiology, 36, 10, 2018. Crossref

  92. Dixon Angela R., Jariwala Shailly H., Bilis Zoe, Loverde Joseph R., Pasquina Paul F., Alvarez Luis M., Bridging the gap in peripheral nerve repair with 3D printed and bioprinted conduits, Biomaterials, 186, 2018. Crossref

  93. Mahumane Gillian Dumsile, Kumar Pradeep, du Toit Lisa Claire, Choonara Yahya Essop, Pillay Viness, 3D scaffolds for brain tissue regeneration: architectural challenges, Biomaterials Science, 6, 11, 2018. Crossref

  94. Patel NiteshP, Lyon KristopherA, Huang JasonH, An update–tissue engineered nerve grafts for the repair of peripheral nerve injuries, Neural Regeneration Research, 13, 5, 2018. Crossref

  95. Wieringa Paul A., Gonçalves de Pinho Ana Rita, Micera Silvestro, Wezel Richard J. A., Moroni Lorenzo, Biomimetic Architectures for Peripheral Nerve Repair: A Review of Biofabrication Strategies, Advanced Healthcare Materials, 7, 8, 2018. Crossref

  96. Behkami Saber, Frounchi Javad, Ghaderi Pakdel Firouz, Stieglitz Thomas, Simulation of effects of the electrode structure and material in the density measuring system of the peripheral nerve based on micro-electrical impedance tomography, Biomedical Engineering / Biomedizinische Technik , 63, 2, 2018. Crossref

  97. Lovati Arianna B., D’Arrigo Daniele, Odella Simonetta, Tos Pierluigi, Geuna Stefano, Raimondo Stefania, Nerve Repair Using Decellularized Nerve Grafts in Rat Models. A Review of the Literature, Frontiers in Cellular Neuroscience, 12, 2018. Crossref

  98. García de Cortázar Unai, Padilla Sabino, Lobato Enrique, Delgado Diego, Sánchez Mikel, Intraneural Platelet-Rich Plasma Injections for the Treatment of Radial Nerve Section: A Case Report, Journal of Clinical Medicine, 7, 2, 2018. Crossref

  99. Magaz Adrián, Faroni Alessandro, Gough Julie E., Reid Adam J., Li Xu, Blaker Jonny J., Bioactive Silk‐Based Nerve Guidance Conduits for Augmenting Peripheral Nerve Repair, Advanced Healthcare Materials, 7, 23, 2018. Crossref

  100. Luo Lihua, He Yan, Wang Xiaoyan, Key Brian, Lee Bae Hoon, Li Huaqiong, Ye Qingsong, Potential Roles of Dental Pulp Stem Cells in Neural Regeneration and Repair, Stem Cells International, 2018, 2018. Crossref

  101. Sun Xun, Zhu Yun, Yin He-yong, Guo Zhi-yuan, Xu Feng, Xiao Bo, Jiang Wen-li, Guo Wei-min, Meng Hao-ye, Lu Shi-bi, Wang Yu, Peng Jiang, Differentiation of adipose-derived stem cells into Schwann cell-like cells through intermittent induction: potential advantage of cellular transient memory function, Stem Cell Research & Therapy, 9, 1, 2018. Crossref

  102. Ikumi Akira, Hara Yuki, Okano Eriko, Kohyama Sho, Arai Norihito, Taniguchi Yu, Sugaya Hisashi, Yoshioka Tomokazu, Kanamori Akihiro, Yamazaki Masashi, Intraoperative Local Administration of Platelet-Rich Plasma (PRP) during Neurolysis Surgery for the Treatment of Digital Nerve Crush Injury, Case Reports in Orthopedics, 2018, 2018. Crossref

  103. Wrobel Melissa R., Sundararaghavan Harini G., Biomaterial Cues to Direct a Pro-regenerative Phenotype in Macrophages and Schwann Cells, Neuroscience, 376, 2018. Crossref

  104. Nakanishi Kazuyoshi, Watanabe Tomoshi, Sunagawa Toru, Kurumadani Hiroshi, Ibrahim Zehry Hanan, Ochi Mitsuo, Adachi Nobuo, Mirror imaging of finger mechanical stimulation affects secondary somatosensory response, NeuroReport, 29, 3, 2018. Crossref

  105. Tajdaran Kasra, Chan Katelyn, Gordon Tessa, Borschel Gregory H., Matrices, scaffolds, and carriers for protein and molecule delivery in peripheral nerve regeneration, Experimental Neurology, 319, 2019. Crossref

  106. Lu Jiaju, Sun Xun, Yin Heyong, Shen Xuezhen, Yang Shuhui, Wang Yu, Jiang Wenli, Sun Yue, Zhao Lingyun, Sun Xiaodan, Lu Shibi, Mikos Antonios G., Peng Jiang, Wang Xiumei, A neurotrophic peptide-functionalized self-assembling peptide nanofiber hydrogel enhances rat sciatic nerve regeneration, Nano Research, 11, 9, 2018. Crossref

  107. Uckermann Ortrud, Hirsch Joana, Galli Roberta, Bendig Jonas, Later Robert, Koch Edmund, Schackert Gabriele, Steiner Gerald, Tanaka Elly, Kirsch Matthias, Label-free Imaging of Tissue Architecture during Axolotl Peripheral Nerve Regeneration in Comparison to Functional Recovery, Scientific Reports, 9, 1, 2019. Crossref

  108. Dietzmeyer Nina, Förthmann Maria, Leonhard Julia, Helmecke Olaf, Brandenberger Christina, Freier Thomas, Haastert-Talini Kirsten, Two-Chambered Chitosan Nerve Guides With Increased Bendability Support Recovery of Skilled Forelimb Reaching Similar to Autologous Nerve Grafts in the Rat 10 mm Median Nerve Injury and Repair Model, Frontiers in Cellular Neuroscience, 13, 2019. Crossref

  109. Yang Jian-Tao, Fang Jin-Tao, Li Liang, Chen Gang, Qin Ben-Gang, Gu Li-Qiang, Contralateral C7 transfer combined with acellular nerve allografts seeded with differentiated adipose stem cells for repairing upper brachial plexus injury in rats, Neural Regeneration Research, 14, 11, 2019. Crossref

  110. Ghorbani Farnaz, Zamanian Ali, Shams Alireza, Shamoosi Atefeh, Aidun Amir, Fabrication and characterisation of super‐paramagnetic responsive PLGA–gelatine–magnetite scaffolds with the unidirectional porous structure: a physicochemical, mechanical, and in vitro evaluation , IET Nanobiotechnology, 13, 8, 2019. Crossref

  111. Liu Juan, Ernst Jennifer, Klingelhoefer Eric, Saul Dominik, Lehmann Wolfgang, Felmerer Gunter, Schilling Arndt F., Translational Challenges in Soft Tissue Regeneration, in Regenerative Medicine and Plastic Surgery, 2019. Crossref

  112. Sakuma Miyuki, Minev Ivan R., Gribi Sandra, Singh Bhagat, Woolf Clifford J., Lacour Stéphanie P., Chronic Electrical Nerve Stimulation as a Therapeutic Intervention for Peripheral Nerve Repair, Bioelectronic Medicine, 2, 1, 2015. Crossref

  113. Dun Xin-Peng, Parkinson DavidB, Classic axon guidance molecules control correct nerve bridge tissue formation and precise axon regeneration, Neural Regeneration Research, 15, 1, 2020. Crossref

  114. Wang Dianri, Wang Yuhao, Tian Weidong, Pan Jian, Advances of tooth‐derived stem cells in neural diseases treatments and nerve tissue regeneration, Cell Proliferation, 52, 3, 2019. Crossref

  115. Endo Takeshi, Kadoya Ken, Kawamura Daisuke, Iwasaki Norimasa, Evidence for cell‐contact factor involvement in neurite outgrowth of dorsal root ganglion neurons stimulated by Schwann cells, Experimental Physiology, 104, 10, 2019. Crossref

  116. Cavanaugh McKay, Silantyeva Elena, Pylypiv Koh Galina, Malekzadeh Elham, Lanzinger William D., Willits Rebecca Kuntz, Becker Matthew L., RGD-Modified Nanofibers Enhance Outcomes in Rats after Sciatic Nerve Injury, Journal of Functional Biomaterials, 10, 2, 2019. Crossref

  117. Pountos Ippokratis, Tellisi Nazzar, Ashammakhi Nureddin, Potential Clinical Applications of Three-Dimensional Bioprinting, in 3D Bioprinting in Medicine, 2019. Crossref

  118. Crosio Alessandro, Fornasari BenedettaElena, Gambarotta Giovanna, Geuna Stefano, Raimondo Stefania, Battiston Bruno, Tos Pierluigi, Ronchi Giulia, Chitosan tubes enriched with fresh skeletal muscle fibers for delayed repair of peripheral nerve defects, Neural Regeneration Research, 14, 6, 2019. Crossref

  119. Schaub Nicholas J., Corey Joseph M., A method to rapidly analyze the simultaneous release of multiple pharmaceuticals from electrospun fibers, International Journal of Pharmaceutics, 574, 2020. Crossref

  120. Jamalpour Mohammad Reza, Vahdatinia Farshid, Vargas Jessica, Tayebi Lobat, Clinical Functions of Regenerative Dentistry and Tissue Engineering in Treatment of Oral and Maxillofacial Soft Tissues, in Applications of Biomedical Engineering in Dentistry, 2020. Crossref

  121. Katiyar Kritika S., Das Suradip, Burrell Justin C., Cullen D. Kacy, Scaffolds for bridging sciatic nerve gaps, in Handbook of Tissue Engineering Scaffolds: Volume Two, 2019. Crossref

  122. Koval Tal, Ofir Shay, Belkin Avner, Segal Ori, Nemet Achia, Nemet Arie Y., Sensory Changes in Periocular Skin After Upper Eyelid Surgery, Journal of Craniofacial Surgery, 30, 1, 2019. Crossref

  123. Sayad-Fathi Sara, Nasiri Ebrahim, Zaminy Arash, Advances in stem cell treatment for sciatic nerve injury, Expert Opinion on Biological Therapy, 19, 4, 2019. Crossref

  124. Manoukian Ohan S., Arul Michael R., Rudraiah Swetha, Kalajzic Ivo, Kumbar Sangamesh G., Aligned microchannel polymer-nanotube composites for peripheral nerve regeneration: Small molecule drug delivery, Journal of Controlled Release, 296, 2019. Crossref

  125. Tariq Rayhan, Malayaman S. Nini, Yan Hong, Iqbal Usama, Li Mingqiang, Zebrower Marcus, Liu Henry, Severe Peripheral Nerve Injury, in Catastrophic Perioperative Complications and Management, 2019. Crossref

  126. Chen Wei, Xiao Shune, Wei Zairong, Deng Chengliang, Nie Kaiyu, Wang Dali, Schwann Cell-Like Cells Derived from Human Amniotic Mesenchymal Stem Cells Promote Peripheral Nerve Regeneration through a MicroRNA-214/c-Jun Pathway, Stem Cells International, 2019, 2019. Crossref

  127. Kaya Hüseyin, Sabah Dündar, Keçeci Burçin, Küçük Levent, Erbaş Oytun, Oltulu Fatih, Yiğittürk Gürkan, Taskiran Dilek, Comparison of the Effects of Extracorporeal Irradiation and Liquid Nitrogen on Nerve Recovery in a Rat Model, Journal of Investigative Surgery, 34, 7, 2021. Crossref

  128. Kuzma Michelle, Gerhard Ethan, Shan Dingying, Yang Jian, Advances in Bioresorbable Electronics and Uses in Biomedical Sensing, in Interfacing Bioelectronics and Biomedical Sensing, 2020. Crossref

  129. Harris James P., Burrell Justin C., Struzyna Laura A., Chen H. Isaac, Serruya Mijail D., Wolf John A., Duda John E., Cullen D. Kacy, Emerging regenerative medicine and tissue engineering strategies for Parkinson’s disease, npj Parkinson's Disease, 6, 1, 2020. Crossref

  130. Vajapey Sravya P., Morris Jesse, Lynch Daniel, Spitzer Andrew, Li Mengnai, Glassman Andrew H., Nerve Injuries with the Direct Anterior Approach to Total Hip Arthroplasty, JBJS Reviews, 8, 2, 2020. Crossref

  131. Ardhani Retno, Ana Ika Dewi, Tabata Yasuhiko, Gelatin hydrogel membrane containing carbonate hydroxyapatite for nerve regeneration scaffold, Journal of Biomedical Materials Research Part A, 108, 12, 2020. Crossref

  132. Pfister Bryan J., Grasman Jonathan M., Loverde Joseph R., Exploiting biomechanics to direct the formation of nervous tissue, Current Opinion in Biomedical Engineering, 14, 2020. Crossref

  133. Raffa Vittoria, Engineering magnetic nanoparticles for repairing nerve injuries, in Advances in Nanostructured Materials and Nanopatterning Technologies, 2020. Crossref

  134. Sousa Sara C., Sousa Mónica M., The cytoskeleton as a modulator of tension driven axon elongation, Developmental Neurobiology, 81, 3, 2021. Crossref

  135. Zuo Kevin J., Saffari Tiam M., Chan Katelyn, Shin Alexander Y., Borschel Gregory H., Systemic and Local FK506 (Tacrolimus) and its Application in Peripheral Nerve Surgery, The Journal of Hand Surgery, 45, 8, 2020. Crossref

  136. Rodriguez-Fontan Francisco, Reeves Bradley, Tuaño Krystle, Colakoglu Salih, D' Agostino Laura, Banegas Rodrigo, Tobacco use and neurogenesis: A theoretical review of pathophysiological mechanism affecting the outcome of peripheral nerve regeneration, Journal of Orthopaedics, 22, 2020. Crossref

  137. Pan Deng, Mackinnon Susan E., Wood Matthew D., Advances in the repair of segmental nerve injuries and trends in reconstruction, Muscle & Nerve, 61, 6, 2020. Crossref

  138. Katiyar Kritika S., Struzyna Laura A., Morand Joseph P., Burrell Justin C., Clements Basak, Laimo Franco A., Browne Kevin D., Kohn Joachim, Ali Zarina, Ledebur Harry C., Smith Douglas H., Cullen D. Kacy, Tissue Engineered Axon Tracts Serve as Living Scaffolds to Accelerate Axonal Regeneration and Functional Recovery Following Peripheral Nerve Injury in Rats, Frontiers in Bioengineering and Biotechnology, 8, 2020. Crossref

  139. Guedan-Duran Atocha, Jemni-Damer Nahla, Orueta-Zenarruzabeitia Irune, Guinea Gustavo Víctor, Perez-Rigueiro José, Gonzalez-Nieto Daniel, Panetsos Fivos, Biomimetic Approaches for Separated Regeneration of Sensory and Motor Fibers in Amputee People: Necessary Conditions for Functional Integration of Sensory–Motor Prostheses With the Peripheral Nerves, Frontiers in Bioengineering and Biotechnology, 8, 2020. Crossref

  140. Puhl Devan L., Funnell Jessica L., Nelson Derek W., Gottipati Manoj K., Gilbert Ryan J., Electrospun Fiber Scaffolds for Engineering Glial Cell Behavior to Promote Neural Regeneration, Bioengineering, 8, 1, 2020. Crossref

  141. Rhode Sophie Charlotte, Beier Justus Patrick, Ruhl Tim, Adipose tissue stem cells in peripheral nerve regeneration— In vitro and in vivo , Journal of Neuroscience Research, 99, 2, 2021. Crossref

  142. Wang Dian-Ri, Wang Yu-Hao, Pan Jian, Tian Wei-Dong, Neurotrophic effects of dental pulp stem cells in repair of peripheral nerve after crush injury, World Journal of Stem Cells, 12, 10, 2020. Crossref

  143. Maggiore Joseph C., Burrell Justin C., Browne Kevin D., Katiyar Kritika S., Laimo Franco A., Ali Zarina S., Kaplan Hilton M., Rosen Joseph M., Cullen D. Kacy, Tissue engineered axon‐based “living scaffolds” promote survival of spinal cord motor neurons following peripheral nerve repair, Journal of Tissue Engineering and Regenerative Medicine, 14, 12, 2020. Crossref

  144. Hopf Alois, Schaefer Dirk J., Kalbermatten Daniel F., Guzman Raphael, Madduri Srinivas, Schwann Cell-Like Cells: Origin and Usability for Repair and Regeneration of the Peripheral and Central Nervous System, Cells, 9, 9, 2020. Crossref

  145. Yan Ji, Wu Ruoyin, Liao Sisi, Jiang Miao, Qian Yun, Applications of Polydopamine-Modified Scaffolds in the Peripheral Nerve Tissue Engineering, Frontiers in Bioengineering and Biotechnology, 8, 2020. Crossref

  146. Xu Zhanyan, Bártolo Paulo Jorge, Scaffold Design for Nerve Regeneration, in Virtual Prototyping & Bio Manufacturing in Medical Applications, 2021. Crossref

  147. Taylor Caroline S., Haycock John W., Biomaterials and Scaffolds for Repair of the Peripheral Nervous System, in Peripheral Nerve Tissue Engineering and Regeneration, 2020. Crossref

  148. Panzer Kate V., Burrell Justin C., Helm Kaila V. T., Purvis Erin M., Zhang Qunzhou, Le Anh D., O’Donnell John C., Cullen D. Kacy, Tissue Engineered Bands of Büngner for Accelerated Motor and Sensory Axonal Outgrowth, Frontiers in Bioengineering and Biotechnology, 8, 2020. Crossref

  149. Burrell Justin C., Bhatnagar Divya, Brown Dan P., Murthy N. Sanjeeva, Dutton John, Browne Kevin D., Laimo Franco A., Ali Zarina S., Rosen Joseph M., Kaplan Hilton M., Kohn Joachim, Cullen D. Kacy, Tyrosine‐derived polycarbonate nerve guidance tubes elicit proregenerative extracellular matrix deposition when used to bridge segmental nerve defects in swine, Journal of Biomedical Materials Research Part A, 109, 7, 2021. Crossref

  150. Tamaki Tetsuro, Biomedical applications of muscle-derived stem cells: from bench to bedside, Expert Opinion on Biological Therapy, 20, 11, 2020. Crossref

  151. Tsuang Fon-Yih, Chen Ming-Hong, Lin Feng-Huei, Yang Ming-Chia, Liao Chun-Jen, Chang Wen-Hsiang, Sun Jui-Sheng, Partial enzyme digestion facilitates regeneration of crushed nerve in rat, Translational Neuroscience, 11, 1, 2020. Crossref

  152. Abuarqoub Duaa, Aslam Nazneen, Almajali Bayan, Shajrawi Leen, Jafar Hanan, Awidi Abdalla, Neuro-regenerative potential of dental stem cells: a concise review, Cell and Tissue Research, 382, 2, 2020. Crossref

  153. Gordon Tessa, Peripheral Nerve Regeneration and Muscle Reinnervation, International Journal of Molecular Sciences, 21, 22, 2020. Crossref

  154. Gilbert Ryan, Pfister Bryan J., Brain organoids/brain tissue engineering — As disease models and for understanding, Current Opinion in Biomedical Engineering, 14, 2020. Crossref

  155. Bolívar Sara, Navarro Xavier, Udina Esther, Schwann Cell Role in Selectivity of Nerve Regeneration, Cells, 9, 9, 2020. Crossref

  156. Maki Daisuke, Tamaki Tetsuro, Fukuzawa Tsuyoshi, Natsume Toshiharu, Yamato Ippei, Uchiyama Yoshiyasu, Saito Kosuke, Okami Kenji, Peripheral Nerve Regeneration Using a Cytokine Cocktail Secreted by Skeletal Muscle-Derived Stem Cells in a Mouse Model, Journal of Clinical Medicine, 10, 4, 2021. Crossref

  157. Vartanian Emma D., Lo Andrea Y., Hershenhouse Korri S., Jacob Laya, Patel Ketan M., The role of neurotization in autologous breast reconstruction: Can reconstruction restore breast sensation?, Journal of Surgical Oncology, 123, 5, 2021. Crossref

  158. Nune Manasa, Subramanian Anuradha, Krishnan Uma Maheswari, Kaimal Suraj Sasidhara, Sethuraman Swaminathan, Self-assembling peptide nanostructures on aligned poly(lactide-co-glycolide) nanofibers for the functional regeneration of sciatic nerve, Nanomedicine, 12, 3, 2017. Crossref

  159. Shultz Robert B, Katiyar Kritika S, Laimo Franco A, Burrell Justin C, Browne Kevin D, Ali Zarina S, Cullen Daniel K, Biopreservation of living tissue engineered nerve grafts, Journal of Tissue Engineering, 12, 2021. Crossref

  160. Pozzobon Laura Gonçalves, Sperling Laura Elena, Teixeira Cristian E., Malysz Tais, Pranke Patricia, Development of a conduit of PLGA-gelatin aligned nanofibers produced by electrospinning for peripheral nerve regeneration, Chemico-Biological Interactions, 348, 2021. Crossref

  161. Zhang Jingxin, Zhang Binjing, Zhang Jinglan, Lin Weimin, Zhang Shiwen, Magnesium Promotes the Regeneration of the Peripheral Nerve, Frontiers in Cell and Developmental Biology, 9, 2021. Crossref

  162. Pugliese Pierfrancesco, De Francesco Francesco, Campodonico Andrea, Pangrazi Pier Paolo, Antonini Andrea, Riccio Michele, Medial Sural Perforator “Nerve through Flap”: Anatomical Study and Clinical Application, Trauma Care, 1, 1, 2021. Crossref

  163. Gordon Tessa, Fu Susan Y., Peripheral nerves preferentially regenerate in intramuscular endoneurial tubes to reinnervate denervated skeletal muscles, Experimental Neurology, 341, 2021. Crossref

  164. Suhar Riley A., Marquardt Laura M., Song Shang, Buabbas Hana, Doulames Vanessa M., Johansson Patrik K., Klett Katarina C., Dewi Ruby E., Enejder Annika M. K., Plant Giles W., George Paul M., Heilshorn Sarah C., Elastin-like Proteins to Support Peripheral Nerve Regeneration in Guidance Conduits, ACS Biomaterials Science & Engineering, 7, 9, 2021. Crossref

  165. Vishnoi Tanushree, Singh Anamika, Teotia Arun K., Kumar Ashok, Chitosan-Gelatin-Polypyrrole Cryogel Matrix for Stem Cell Differentiation into Neural Lineage and Sciatic Nerve Regeneration in Peripheral Nerve Injury Model, ACS Biomaterials Science & Engineering, 5, 6, 2019. Crossref

  166. Xu Jianyi, Yin Xiaofeng, Qi Yisong, Chen Bo, Li Yusha, Wan Peng, Yao Yingtao, Zhu Dan, Jiang Baoguo, Yu Tingting, Three-Dimensional Mapping of Retrograde Multi-Labeled Motor Neuron Columns in the Spinal Cord, Photonics, 8, 5, 2021. Crossref

  167. Rochkind Shimon, Almog Mara, Meilin Sigal, Nevo Zvi, Reviving Matrix for Nerve Reconstruction in Rabbit Model of Chronic Peripheral Nerve Injury With Massive Loss Defect, Frontiers in Surgery, 7, 2021. Crossref

  168. Chen Shuhai, Ikemoto Tetsuya, Tokunaga Takuya, Okikawa Shohei, Miyazaki Katsuki, Tokuda Kazunori, Yamada Shinichiro, Saito Yu, Imura Satoru, Morine Yuji, Shimada Mitsuo, Effective <i>in vitro</i> differentiation of adipose-derived stem cells into Schwann-like cells with folic acid supplementation, The Journal of Medical Investigation, 68, 3.4, 2021. Crossref

  169. McCulloch Ian, Valerio Ian, Lower extremity reconstruction for limb salvage and functional restoration - The Combat experience, Clinics in Plastic Surgery, 48, 2, 2021. Crossref

  170. Manoukian Ohan S., Rudraiah Swetha, Arul Michael R., Bartley Jenna M., Baker Jiana T., Yu Xiaojun, Kumbar Sangamesh G., Biopolymer-nanotube nerve guidance conduit drug delivery for peripheral nerve regeneration: In vivo structural and functional assessment, Bioactive Materials, 6, 9, 2021. Crossref

  171. Sakaue Motoharu, Sieber-Blum Maya, Human epidermal neural crest stem cells as a source of Schwann cells, Development, 2015. Crossref

  172. Mota Carlos, Camarero-Espinosa Sandra, Baker Matthew B., Wieringa Paul, Moroni Lorenzo, Bioprinting: From Tissue and Organ Development to in Vitro Models, Chemical Reviews, 120, 19, 2020. Crossref

  173. Xue Wen, Shi Wen, Kong Yunfan, Kuss Mitchell, Duan Bin, Anisotropic scaffolds for peripheral nerve and spinal cord regeneration, Bioactive Materials, 6, 11, 2021. Crossref

  174. D. Alvites Rui, V. Branquinho Mariana, Sousa Ana C., Zen Federica, Maurina Monica, Raimondo Stefania, Mendonça Carla, Atayde Luís, Geuna Stefano, Varejão Artur S.P., Maurício Ana C., Establishment of a Sheep Model for Hind Limb Peripheral Nerve Injury: Common Peroneal Nerve, International Journal of Molecular Sciences, 22, 3, 2021. Crossref

  175. Rose Ryan Adam, Bliss Ryan, Bromage Timothy, Hu Bin, Gopman Jared M., Melamed Eitan, The Cutting Edge: Surface Texture Analysis following Resection of Nerve Stumps Using Various Instruments, Plastic and Reconstructive Surgery - Global Open, 9, 5, 2021. Crossref

  176. Cottilli Patrick, Gaja-Capdevila Núria, Navarro Xavier, Effects of Sigma-1 Receptor Ligands on Peripheral Nerve Regeneration, Cells, 11, 7, 2022. Crossref

  177. Roberts Sanford E., Burrell Justin C., Comments on “Comparison between normal and reverse orientation of graft in functional and histomorphological outcomes after autologous nerve grafting: An experimental study in the mouse model”, Microsurgery, 42, 4, 2022. Crossref

  178. Howarth HollyM, Alaziz Turki, Nicolds Brogan, O'Connor Shawn, Shah SameerB, Redistribution of nerve strain enables end-to-end repair under tension without inhibiting nerve regeneration, Neural Regeneration Research, 14, 7, 2019. Crossref

  179. Dursun Usal Tugba, Yesiltepe Metin, Yucel Deniz, Sara Yıldırım, Hasirci Vasif, Fabrication of a 3D Printed PCL Nerve Guide: In Vitro and In Vivo Testing, Macromolecular Bioscience, 22, 3, 2022. Crossref

  180. Siriwardane Mevan L., Derosa Kathleen, Collins George, Pfister Bryan J., Engineering Fiber-Based Nervous Tissue Constructs for Axon Regeneration, Cells Tissues Organs, 210, 2, 2021. Crossref

  181. Roca Fernando Gisbert, Santos Luis Gil, Roig Manuel Mata, Medina Lara Milian, Martínez-Ramos Cristina, Pradas Manuel Monleón, Novel Tissue-Engineered Multimodular Hyaluronic Acid-Polylactic Acid Conduits for the Regeneration of Sciatic Nerve Defect, Biomedicines, 10, 5, 2022. Crossref

  182. Mayilswamy Neelaambhigai, Jaya Prakash Niranjana, Kandasubramanian Balasubramanian, Design and fabrication of biodegradable electrospun nanofibers loaded with biocidal agents, International Journal of Polymeric Materials and Polymeric Biomaterials, 2022. Crossref

  183. Das Suradip, Gordián-Vélez Wisberty J., Ledebur Harry C., Mourkioti Foteini, Rompolas Panteleimon, Chen H. Isaac, Serruya Mijail D., Cullen D. Kacy, Innervation: the missing link for biofabricated tissues and organs, npj Regenerative Medicine, 5, 1, 2020. Crossref

  184. Lopez-Silva Tania L., Cristobal Carlo D., Edwin Lai Cheuk Sun, Leyva-Aranda Viridiana, Lee Hyun Kyoung, Hartgerink Jeffrey D., Self-assembling multidomain peptide hydrogels accelerate peripheral nerve regeneration after crush injury, Biomaterials, 265, 2021. Crossref

  185. Zeng Xiao Xue, Zeng Jianwen, Zhu Baoyi, Future generation of combined multimodal approach to treat brain glioblastoma multiforme and potential impact on micturition control, Reviews in the Neurosciences, 33, 3, 2022. Crossref

  186. Fadia Neil B., Bliley Jacqueline M., DiBernardo Gabriella A., Crammond Donald J., Schilling Benjamin K., Sivak Wesley N., Spiess Alexander M., Washington Kia M., Waldner Matthias, Liao Han-Tsung, James Isaac B., Minteer Danielle M., Tompkins-Rhoades Casey, Cottrill Adam R., Kim Deok-Yeol, Schweizer Riccardo, Bourne Debra A., Panagis George E., Asher Schusterman M., Egro Francesco M., Campwala Insiyah K., Simpson Tyler, Weber Douglas J., Gause Trent, Brooker Jack E., Josyula Tvisha, Guevara Astrid A., Repko Alexander J., Mahoney Christopher M., Marra Kacey G., Long-gap peripheral nerve repair through sustained release of a neurotrophic factor in nonhuman primates, Science Translational Medicine, 12, 527, 2020. Crossref

  187. Girard Alisa O., Lake Isabel V., Lopez Christopher D., Kalsi Richa, Brandacher Gerald, Cooney Damon S., Redett Richard J., Vascularized composite allotransplantation of the penis: current status and future perspectives, International Journal of Impotence Research, 34, 4, 2022. Crossref

  188. Mokarram Nassir, Dymanus Kyle, Srinivasan Akhil, Lyon Johnathan G., Tipton John, Chu Jason, English Arthur W., Bellamkonda Ravi V., Immunoengineering nerve repair, Proceedings of the National Academy of Sciences, 114, 26, 2017. Crossref

  189. Chen Shuhai, Ikemoto Tetsuya, Tokunaga Takuya, Okikawa Shouhei, Miyazaki Katsuki, Yamada Shinichiro, Saito Yu, Morine Yuji, Shimada Mitsuo, Newly Generated 3D Schwann-Like Cell Spheroids From Human Adipose-Derived Stem Cells Using a Modified Protocol, Cell Transplantation, 31, 2022. Crossref

  190. Gisbert Roca Fernando, Serrano Requena Sara, Monleón Pradas Manuel, Martínez-Ramos Cristina, Electrical Stimulation Increases Axonal Growth from Dorsal Root Ganglia Co-Cultured with Schwann Cells in Highly Aligned PLA-PPy-Au Microfiber Substrates, International Journal of Molecular Sciences, 23, 12, 2022. Crossref

  191. Zhu Yaqiong, Peng Nan, Wang Jing, Jin Zhuang, Zhu Lianhua, Wang Yu, Chen Siming, Hu Yongqiang, Zhang Tieyuan, Song Qing, Xie Fang, Yan Lin, Li Yingying, Xiao Jing, Li Xinyang, Jiang Bo, Peng Jiang, Wang Yuexiang, Luo Yukun, Peripheral nerve defects repaired with autogenous vein grafts filled with platelet-rich plasma and active nerve microtissues and evaluated by novel multimodal ultrasound techniques, Biomaterials Research, 26, 1, 2022. Crossref

  192. Murphy Ralph N A, Elsayed Heba, Singh Sahiba, Dumville Jo, Wong Jason K F, Reid Adam J, A Quantitative Systematic Review of Clinical Outcome Measure Use in Peripheral Nerve Injury of the Upper Limb, Neurosurgery, 89, 1, 2021. Crossref

  193. Jia Yachao, Yang Weichao, Zhang Kuihua, Qiu Shuo, Xu Jia, Wang Chunyang, Chai Yimin, Nanofiber arrangement regulates peripheral nerve regeneration through differential modulation of macrophage phenotypes, Acta Biomaterialia, 83, 2019. Crossref

  194. Romero-Ortega Mario, Peripheral Nerves, Anatomy and Physiology of, in Encyclopedia of Computational Neuroscience, 2022. Crossref

  195. Petrov Dmitriy, Burrell Justin C., Browne Kevin D., Laimo Franco A., Roberts Sanford E., Ali Zarina S., Cullen D. Kacy, Neurorrhaphy in Presence of Polyethylene Glycol Enables Immediate Electrophysiological Conduction in Porcine Model of Facial Nerve Injury, Frontiers in Surgery, 9, 2022. Crossref

  196. Ma Fukai, Zhu Tongming, Xu Feng, Wang Zhifu, Zheng Yongtao, Tang Qisheng, Chen Luping, Shen Yiwen, Zhu Jianhong, Neural stem/progenitor cells on collagen with anchored basic fibroblast growth factor as potential natural nerve conduits for facial nerve regeneration, Acta Biomaterialia, 50, 2017. Crossref

  197. Vijayavenkataraman Sanjairaj, Thaharah Siti, Zhang Shuo, Lu Wen Feng, Fuh Jerry Ying Hsi, Electrohydrodynamic jet 3D-printed PCL/PAA conductive scaffolds with tunable biodegradability as nerve guide conduits (NGCs) for peripheral nerve injury repair, Materials & Design, 162, 2019. Crossref

  198. Wariyar Supriya S., Brown Alden D., Tian Tina, Pottorf Tana S., Ward Patricia J., Angiogenesis is critical for the exercise-mediated enhancement of axon regeneration following peripheral nerve injury, Experimental Neurology, 353, 2022. Crossref

  199. Roche Phoebe, Alekseeva Tijna, Widaa Amro, Ryan Alan, Matsiko Amos, Walsh Michael, Duffy Garry P., O'Brien Fergal J., Olfactory Derived Stem Cells Delivered in a Biphasic Conduit Promote Peripheral Nerve Repair In Vivo, Stem Cells Translational Medicine, 6, 10, 2017. Crossref

  200. Burrell Justin C, Browne Kevin D, Dutton John L, Laimo Franco A, Das Suradip, Brown Daniel P, Roberts Sanford, Petrov Dmitriy, Ali Zarina, Ledebur Harry C, Rosen Joseph M, Kaplan Hilton M, Wolf John A, Smith Douglas H, Chen H Isaac, Cullen D Kacy, A Porcine Model of Peripheral Nerve Injury Enabling Ultra-Long Regenerative Distances: Surgical Approach, Recovery Kinetics, and Clinical Relevance, Neurosurgery, 87, 4, 2020. Crossref

  201. Kaplan Ben, Levenberg Shulamit, The Role of Biomaterials in Peripheral Nerve and Spinal Cord Injury: A Review, International Journal of Molecular Sciences, 23, 3, 2022. Crossref

  202. Wofford Kathryn L., Shultz Robert B., Burrell Justin C., Cullen D. Kacy, Neuroimmune interactions and immunoengineering strategies in peripheral nerve repair, Progress in Neurobiology, 208, 2022. Crossref

  203. Taylor Caroline S., Haycock John W., Biomaterials and Scaffolds for Repair of the Peripheral Nervous System, in Peripheral Nerve Tissue Engineering and Regeneration, 2022. Crossref

  204. Ren Jingyan, Tang Xiaoduo, Wang Tao, Wei Xin, Zhang Junhu, Lu Laijin, Liu Yang, Yang Bai, A Dual‐Modal Magnetic Resonance/Photoacoustic Imaging Tracer for Long‐Term High‐Precision Tracking and Facilitating Repair of Peripheral Nerve Injuries, Advanced Healthcare Materials, 11, 13, 2022. Crossref

  205. Naghilou Aida, Pöttschacher Lena, Millesi Flavia, Mann Anda, Supper Paul, Semmler Lorenz, Weiss Tamara, Backus Ellen H.G., Radtke Christine, Correlating the secondary protein structure of natural spider silk with its guiding properties for Schwann cells, Materials Science and Engineering: C, 116, 2020. Crossref

  206. Hopf Alois, Al-Bayati Lina, Schaefer Dirk J., Kalbermatten Daniel F., Guzman Raphael, Madduri Srinivas, Optimized Decellularization Protocol for Large Peripheral Nerve Segments: Towards Personalized Nerve Bioengineering, Bioengineering, 9, 9, 2022. Crossref

  207. Burrell Justin C., Das Suradip, Laimo Franco A., Katiyar Kritika S., Browne Kevin D., Shultz Robert B., Tien Vishal J., Vu Phuong T., Petrov Dmitriy, Ali Zarina S., Rosen Joseph M., Cullen D. Kacy, Engineered neuronal microtissue provides exogenous axons for delayed nerve fusion and rapid neuromuscular recovery in rats, Bioactive Materials, 18, 2022. Crossref

  208. Palispis Winnie A., Gupta Ranjan, Biologic Augmentation in Peripheral Nerve Repair, in Biologics in Orthopaedic Surgery, 2019. Crossref

  209. Contreras Estefanía, Bolívar Sara, Nieto-Nicolau Núria, Fariñas Oscar, López-Chicón Patrícia, Navarro Xavier, Udina Esther, A novel decellularized nerve graft for repairing peripheral nerve long gap injury in the rat, Cell and Tissue Research, 2022. Crossref

  210. Maeng Woo-Youl, Tseng Wan-Ling, Li Song, Koo Jahyun, Hsueh Yuan-Yu, Electroceuticals for peripheral nerve regeneration, Biofabrication, 14, 4, 2022. Crossref

  211. Perrelle Jeremy M., Boreland Andrew J., Gamboa Jasmine M., Gowda Prarthana, Murthy N. Sanjeeva, Biomimetic Strategies for Peripheral Nerve Injury Repair: An Exploration of Microarchitecture and Cellularization, Biomedical Materials & Devices, 2022. Crossref

  212. Chau Monica J., Quintero Jorge E., Blalock Eric, Byrum Stephanie, Mackintosh Samuel G., Samaan Christopher, Gerhardt Greg A., van Horne Craig G., Wen Rong, Transection injury differentially alters the proteome of the human sural nerve, PLOS ONE, 17, 11, 2022. Crossref

  213. El Soury Marwa, García-García ÓscarDarío, Tarulli Isabella, Chato-Astrain Jesús, Perroteau Isabelle, Geuna Stefano, Raimondo Stefania, Gambarotta Giovanna, Carriel Víctor, Chitosan conduits enriched with fibrin-collagen hydrogel with or without adipose-derived mesenchymal stem cells for the repair of 15-mm-long sciatic nerve defect, Neural Regeneration Research, 18, 6, 2023. Crossref

  214. Contreras Estefanía, Traserra Sara, Bolívar Sara, Forés Joaquim, Jose-Cunilleras Eduard, García Felix, Delgado-Martínez Ignacio, Holmgren Sandra, Strehl Raimund, Udina Esther, Navarro Xavier, Repair of Long Nerve Defects with a New Decellularized Nerve Graft in Rats and in Sheep, Cells, 11, 24, 2022. Crossref

  215. Milek David, Echternacht Scott R, LaGuardia Jonnby, LaBarge Dalton, Turpin Loel, Grobbelaar Adriaan, Leckenby Jonathan I, Evaluation of peripheral nerve regeneration in Murphy Roths Large mouse strain following transection injury, Regenerative Medicine, 18, 1, 2023. Crossref

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