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ISSN Печать: 1045-4403
ISSN Онлайн: 2162-6502
Indexed in
Target Genes and Cellular Regulators of the Мус Transcription Complex
Краткое описание
Precisely how the Myc proteins promote cellular growth and transformation remains an enigma. Structural and functional studies unequivocally demonstrate that Myc proteins have the potential to function as regulators of gene transcription in vivo. Therefore, the current view is that Myc-induced cellular growth is orchestrated by products of the genes regulated by Myc and that efforts to curtail Myc function are best directed toward the accessory proteins that interact with Myc to modulate its function as a transcription factor. This review is focused on recent work designed to identify the genetic targets of Myc activity in cells and to characterize Myc-interacting proteins. These studies have provided an intriguing set of molecular tools that can be exploited to generate new information on the role of Myc in cell growth and oncogenic transformation.
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Daumer Kathleen M., Taparowsky Elizabeth J., Hall David J., Steinbeck Marla J., Transcription From the Tartrate-resistant Acid Phosphatase Promoter Is Negatively Regulated by the Myc Oncoprotein, Journal of Bone and Mineral Research, 17, 9, 2002. Crossref
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Oster Sara K., Ho Cynthia S.W., Soucie Erinn L., Penn Linda Z., , 84, 2002. Crossref
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Sosinsky Alona, Glusman Gustavo, Lancet Doron, The Genomic Structure of Human Olfactory Receptor Genes, Genomics, 70, 1, 2000. Crossref
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Jacobs Heinz, TCR-independent T cell development mediated by gain-of-oncogene function or loss-of-tumor-suppressor gene function, Seminars in Immunology, 12, 5, 2000. Crossref
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Vanden Heuvel J.P., Receptor-Mediated Carcinogenesis, in Comprehensive Toxicology, 2010. Crossref
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Wang Xueyan, Peters Mette A., Utama Fransiscus E., Wang Yuzhen, Taparowsky Elizabeth J., The Adrenomedullin Gene Is a Target for Negative Regulation by the Myc Transcription Complex, Molecular Endocrinology, 13, 2, 1999. Crossref
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Burton Robert A., Mattila Sampo, Taparowsky Elizabeth J., Post Carol Beth, B-Myc: N-Terminal Recognition of Myc Binding Proteins, Biochemistry, 45, 32, 2006. Crossref
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Luo Qi, Li Jun, Cenkci Belgin, Kretzner Leo, Autorepression of c-myc requires both initiator and E2F-binding site elements and cooperation with the p107 gene product, Oncogene, 23, 5, 2004. Crossref
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Meroni Germana, Cairo Stefano, Merla Giuseppe, Messali Silvia, Brent Roger, Ballabio Andrea, Reymond Alexandre, Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?, Oncogene, 19, 29, 2000. Crossref
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McMahon Steven B., Wood Marcelo A., Cole Michael D., The Essential Cofactor TRRAP Recruits the Histone Acetyltransferase hGCN5 to c-Myc, Molecular and Cellular Biology, 20, 2, 2000. Crossref
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Dudley JP, Mertz JA, Rajan L, Lozano M, Broussard DR, What retroviruses teach us about the involvement of c-Myc in leukemias and lymphomas, Leukemia, 16, 6, 2002. Crossref