Выходит 12 номеров в год
ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344
Indexed in
Potential Benefits of Ling Zhi or Reishi Mushroom Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) to Breast Cancer Patients
Краткое описание
We present a model case study of a stage IIIa breast cancer patient adapting to the adjuvant use of Ganoderma lucidum in conjunction with a standard regimen of breast cancer treatments (presurgery ACT chemotherapy, surgery, radiotherapy, and postsurgery chemoprevention). According to the personal account of the authors of this research, G. lucidum triterpene-enriched polysaccharide extract of a new hybrid, Reishi Gano 161, containing 12% β-D-glucan and 6% triterpenes, was beneficial to the patient in numerous ways, such as effective tumor shrinkage, minimal or transient side effects from chemotherapy and radiotherapy, and improvement of the quality of life, compared to the experience of patients who used only conventional cancer treatments. New studies unveiled the molecular mechanism of the antitumor activity of this legendary medicinal mushroom, which appeared to be based on the inhibition of the nuclear transcription factor, NF-kappaB (NF-κB). NF-κB is overexpressed in various cancer cell lines and can serve as a molecular target for the development of more precise chemoprevention and anticancer therapy.
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Feng Jie, Feng Na, Zhang Jing-Song, Yang Yan, Jia Wei, Lin Chi-Chung, A New Temperature Control Shifting Strategy for Enhanced Triterpene Production by Ganoderma lucidum G0119 Based on Submerged Liquid Fermentation, Applied Biochemistry and Biotechnology, 180, 4, 2016. Crossref
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Xu Jing, Chen Fengyuan, Wang Guoquan, Liu Bin, Song Hang, Ma Teng, The Versatile Functions of G. Lucidum Polysaccharides and G. Lucidum Triterpenes in Cancer Radiotherapy and Chemotherapy, Cancer Management and Research, Volume 13, 2021. Crossref
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Luangharn Thatsanee, Karunarathna Samantha C., Dutta Arun Kumar, Paloi Soumitra, Promputtha Itthayakorn, Hyde Kevin D., Xu Jianchu, Mortimer Peter E., Ganoderma (Ganodermataceae, Basidiomycota) Species from the Greater Mekong Subregion, Journal of Fungi, 7, 10, 2021. Crossref
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Chugh Rishi Man, Mittal Pooja, MP Namratha, Arora Tanu, Bhattacharya Tanima, Chopra Hitesh, Cavalu Simona, Gautam Rupesh K., Fungal Mushrooms: A Natural Compound With Therapeutic Applications, Frontiers in Pharmacology, 13, 2022. Crossref
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Oke M. A., Afolabi F. J., Oyeleke O. O., Kilani T. A., Adeosun A. R., Olanbiwoninu A. A., Adebayo E. A., Ganoderma lucidum: Unutilized natural medicine and promising future solution to emerging diseases in Africa, Frontiers in Pharmacology, 13, 2022. Crossref