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International Journal of Medicinal Mushrooms
Главный редактор: Solomon P. Wasser (open in a new tab)

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ISSN Печать: 1521-9437

ISSN Онлайн: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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An Improved Method for the Isolation of Lentinan from the Edible and Medicinal Shiitake Mushroom, Lentinus edodes (Berk.) Sing. (Agaricomycetideae)

Том 3, Выпуск 1, 2001, 11 pages
DOI: 10.1615/IntJMedMushr.v3.i1.20
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Краткое описание

A more efficient procedure for the extraction of β-D-glucan from Lentinus edodes (Berk.) Sing, (shiitake mushroom) was designed in this study. The β-D-glucan isolated through ethanol precipitation and freeze drying in liquid nitrogen was found to be lentinan. Purity tests carried out using a carbohydrate analysis column, a chromatographic method, has shown a significant lentinan purity of 87.50%. The commercial value of this method is increased further by its being less time consuming, more efficient, and of low cost. Three experiments involving mouse models were designed to evaluate the efficacy of this extract. The pretreatment cohort was to administer this lentinan for 7 days before inoculation with the K36 cells (murine leukemic cell line). In the simultaneous-treatment cohort lentinan was administered together with the inoculation of K36 cells for 7 days. Lastly, in the posttreatment cohort, lentinan was administered 7 days after tumor cells had been inoculated. The highest antitumor activity was observed with the pretreatment cohort. Tumor inhibition rates (TIRs) of 94.44%, 88.59%, and 83.14% were observed with pretreatment, simultaneous-treatment, and posttreatment, respectively. In comparison, a crude L. edodes homogenate showed TIRs of 55.20%, 45.32%, and 43.06%, respectively, for the three experiments. This indicated that extracted lentinan was much more effective in the prevention of tumor formation. Ultrastructural studies revealed a drastic reduction in the number of retroviruses in the induced tumor and most of those were defective. In addition, significant induction of interferon-γ, tumor necrosis factor-α, and interleukin-2 was observed in the mouse model. Thus, host T-cell stimulations by lentinan could well have a role in the antitumor activity observed.

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