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ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344
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Pharmacological Properties of Biocompounds from Spores of the Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes): A Review
Краткое описание
Ganoderma lucidum is a well-known representative of mushrooms that have been used in traditional Chinese medicine for centuries. New discoveries related to this medicinal mushroom and its biological properties are frequently reported. However, only recently have scientists started to pay special attention to G. lucidum spores. This is in part because of the recent development of methods for breaking the spore wall and extracting biocompounds from the spore. Although some research groups are working with G. lucidum spores, data in the literature are still limited, and the methods used have not been systematized. This review therefore describes the main advances in techniques for breaking the spore wall and extracting biocompounds from the spore. In addition, the major active components identified and their biological properties, such as neurological activity and antiaging and cell-protective effects, are investigated because these are of importance for potential drug development.
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Tran Phuong Thao, Dat Nguyen Tien, Dang Nguyen Hai, Van Cuong Pham, Lee Suhyun, Hwangbo Cheol, Van Minh Chau, Lee Jeong-Hyung, Ganomycin I from Ganoderma lucidum attenuates RANKL-mediated osteoclastogenesis by inhibiting MAPKs and NFATc1, Phytomedicine, 55, 2019. Crossref
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Wang Zichao, Zhang Huiru, Shen Yingbin, Zhao Xiaoxiao, Wang Xueqin, Wang Jiaqi, Fan Kun, Zhan Xiaobei, Characterization of a novel polysaccharide from Ganoderma lucidum and its absorption mechanism in Caco-2 cells and mice model, International Journal of Biological Macromolecules, 118, 2018. Crossref
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Huang , Li , Chen , Liu , Wang , GPP (Composition of Ganoderma Lucidum Poly-saccharides and Polyporus Umbellatus Poly-saccharides) Enhances Innate Immune Function in Mice, Nutrients, 11, 7, 2019. Crossref
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Lian Danhong, Zhong Xin, Zheng Yimei, Zhou Sha, Gu Li, Liu Xin, A New Sterol From Sporoderm-Broken Ganoderma sinense Spores and Its Anticancer Activity, Natural Product Communications, 14, 12, 2019. Crossref
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Zhu Li-Fang, Chen Xianle, Ahmad Zeeshan, Li Jing-Song, Chang Ming-Wei, Engineering of Ganoderma lucidum polysaccharide loaded polyvinyl alcohol nanofibers for biopharmaceutical delivery, Journal of Drug Delivery Science and Technology, 50, 2019. Crossref
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Çelik B., Özparlak H., Determination of genotoxic and antigenotoxic effects of wild-grown Reishi mushroom (Ganoderma lucidum) using the hen’s egg test for analysis of micronucleus induction, Biotechnic & Histochemistry, 94, 8, 2019. Crossref
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Chen Lihua, Abulizi Abudumijiti, Li Min, Protective Effect of Ganoderma (Lingzhi) on Radiation and Chemotherapy, in Ganoderma and Health, 1182, 2019. Crossref
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Wang Gan, Wang Le, Zhou Jianlong, Xu Xiaoxin, The Possible Role of PD-1 Protein in Ganoderma lucidum–Mediated Immunomodulation and Cancer Treatment, Integrative Cancer Therapies, 18, 2019. Crossref
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Li Zhenhao, Shi Yingqiu, Zhang Xiaohui, Xu Jing, Wang Hanbo, Zhao Lu, Wang Yi, Screening Immunoactive Compounds of Ganoderma lucidum Spores by Mass Spectrometry Molecular Networking Combined With in vivo Zebrafish Assays, Frontiers in Pharmacology, 11, 2020. Crossref
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Saavedra Plaza Diana Carolina, Soccol Carlos Ricardo, Noseda Miguel Daniel, Oliveira de Andrade Tanobe Valcineide, Marin Oranys, Karp Susan Grace, De Melo Pereira Gilberto Vinicius, De Carvalho Júlio Cesar, Thomaz Soccol Vanete, A comparative study of extraction techniques for maximum recovery of bioactive compounds from Ganoderma lucidum spores, Revista Colombiana de Ciencias Químico-Farmacéuticas, 49, 1, 2020. Crossref
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Salvatore Maria Michela, Elvetico Alessandro, Gallo Monica, Salvatore Francesco, DellaGreca Marina, Naviglio Daniele, Andolfi Anna, Fatty Acids from Ganoderma lucidum Spores: Extraction, Identification and Quantification, Applied Sciences, 10, 11, 2020. Crossref
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Li Changqin, Cui Yiping, Lu Jie, Liu Cunyu, Chen Sitan, Ma Changyang, Liu Zhenhua, Wang Jinmei, Kang Wenyi, Ionic Liquid-Based Ultrasonic-Assisted Extraction Coupled with HPLC and Artificial Neural Network Analysis for Ganoderma lucidum, Molecules, 25, 6, 2020. Crossref
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Wang Li, Li Jie-qing, Zhang Ji, Li Zhi-min, Liu Hong-gao, Wang Yuan-zhong, Traditional uses, chemical components and pharmacological activities of the genus Ganoderma P. Karst.: a review, RSC Advances, 10, 69, 2020. Crossref
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Zhao Xiaohui , Zhou Dayu , Liu Yunen , Li Chun , Zhao Xiaoguang , Li Ying , Li Wei , Ganoderma lucidum polysaccharide inhibits prostate cancer cell migration via the protein arginine methyltransferase 6 signaling pathway, Molecular Medicine Reports, 2017. Crossref
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He Jiaming, Zhang Wenkan, Di Tuoyu, Meng Jiahong, Qi Yiying, Li Guoqi, Zhang Yuxiang, Su Hang, Yan Weiqi, Water extract of sporoderm-broken spores of Ganoderma lucidum enhanced pd-l1 antibody efficiency through downregulation and relieved complications of pd-l1 monoclonal antibody, Biomedicine & Pharmacotherapy, 131, 2020. Crossref
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Liu Yadi, Lai Guoxiao, Guo Yinrui, Tang Xiaocui, Shuai Ou, Xie Yizhen, Wu Qingping, Chen Diling, Yuan Xujiang, Protective effect of Ganoderma lucidum spore extract in trimethylamine‐ N ‐oxide‐induced cardiac dysfunction in rats , Journal of Food Science, 86, 2, 2021. Crossref
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Li Changqin, Cui Yiping, Lu Jie, Meng Lijun, Ma Changyang, Liu Zhenhua, Zhang Yan, Kang Wenyi, Spectrum-effect relationship of immunologic activity of Ganoderma lucidum by UPLC-MS/MS and component knock-out method, Food Science and Human Wellness, 10, 3, 2021. Crossref
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Cai Manjun, Liang Xiaowei, Liu Yuanchao, Hu Huiping, Xie Yizhen, Chen Shaodan, Gao Xiong, Li Xiangmin, Xiao Chun, Chen Diling, Wu Qingping, Transcriptional Dynamics of Genes Purportedly Involved in the Control of Meiosis, Carbohydrate, and Secondary Metabolism during Sporulation in Ganoderma lucidum, Genes, 12, 4, 2021. Crossref
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Xu Yicen, Yu Jie, The Trend of Ganoderma Lucidum Research (1936–2019), in The Lingzhi Mushroom Genome, 2021. Crossref
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Zhao Hui-Ling, Cui Su-Ying, Qin Yu, Liu Yu-Tong, Cui Xiang-Yu, Hu Xiao, Kurban Nurhumar, Li Ming-Yan, Li Zhen-Hao, Xu Jing, Zhang Yong-He, Prophylactic effects of sporoderm-removed Ganoderma lucidum spores in a rat model of streptozotocin-induced sporadic Alzheimer's disease, Journal of Ethnopharmacology, 269, 2021. Crossref
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Li Ran, Tang Xiaocui, Xu Changqiong, Guo Yinrui, Qi Longkai, Li Shan, Ren Qiuyun, Jie Wu, Chen Diling, Circular RNA NF1-419 Inhibits Proliferation and Induces Apoptosis by Regulating Lipid Metabolism in Astroglioma Cells, Recent Patents on Anti-Cancer Drug Discovery, 17, 2, 2022. Crossref
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Lv Xu-Cong, Wu Qi, Cao Ying-Jia, Lin Yi-Chen, Guo Wei-Ling, Rao Ping-Fan, Zhang Yan-Yan, Chen You-Ting, Ai Lian-Zhong, Ni Li, Ganoderic acid A from Ganoderma lucidum protects against alcoholic liver injury through ameliorating the lipid metabolism and modulating the intestinal microbial composition, Food & Function, 13, 10, 2022. Crossref
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Rosales-López Catalina, Vargas-López Alejandro, Monge-Artavia Mariana, Rojas-Chaves Miguel, Evaluation of Conditions to Improve Biomass Production by Submerged Culture of Ganoderma sp., Microorganisms, 10, 7, 2022. Crossref
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Lai Peng, Cao Xu, Xu Qiao, Liu Yixin, Li Rui, Zhang Ju, Zhang Meng, Ganoderma lucidum spore ethanol extract attenuates atherosclerosis by regulating lipid metabolism via upregulation of liver X receptor alpha, Pharmaceutical Biology, 58, 1, 2020. Crossref
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Chen Jing, He Xiu, Song Yawen, Tu Ying, Chen Wenyan, Yang Guanghong, Sporoderm-broken spores of Ganoderma lucidum alleviates liver injury induced by DBP and BaP co-exposure in rat, Ecotoxicology and Environmental Safety, 241, 2022. Crossref
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Keekan K. K., Ranadive K. R., Naik P., Sendker J., Padmaraj S. R., Anti-Methicillin-Resistant S. aureus Activity of Fruiting Body and Mycelial Culture Extracts of Xylaria longipes Nitschke (Ascomycota), Pharmaceutical Chemistry Journal, 56, 7, 2022. Crossref
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Zou Pan, Guo Yongze, Ding Shu, Song Zhaowei, Cui Hanyuan, Zhang Yue, Zhang Zhijun, Chen Xiaoming, Autotoxicity of Endogenous Organic Acid Stress in Two Ganoderma lucidum Cultivars, Molecules, 27, 19, 2022. Crossref