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ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344
Indexed in
Metabolomic Investigation of Rat Serum Following Oral Administration of the Willow Bracket Medicinal Mushroom, Phellinus igniarius (Agaricomycetes), by UPLC-HDMS
Краткое описание
The medicinal willow bracket mushroom, Phellinus igniarius, is a species that has been reported to possess antibacterial, antioxidative, antitumor, antidiabetic, and antihyperlipidemia activities. The aim of this study was to elucidate the changes in endogenous metabolites after oral administration of a decoction of Ph. Igniarius. Ultraperformance liquid chromatography (UPLC)/electrospray ionization synapt high-definition mass spectrometry (ESI-HDMS) combined with pattern recognition approaches, including principal component analysis and orthogonal partial least squares discriminant analysis, were integrated to discover differentiating metabolites. The current metabolomics approach identified 16 ions (5 in the negative mode, 11 in the positive mode) as "differentiating metabolites". The results illustrated that Ph. Igniarius is likely to increase the biosynthesis and secretion of bile acids that provide hypolipidemic activity and showed that robust UPLC/ESI-HDMS techniques are promising for profiling analysis of medicinal mushroom metabolites.
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Dong Yu, Qiu Ping, Zhao Lisha, Zhang Pinghu, Huang Xiaowen, Li Changyu, Chai Kequn, Shou Dan, Metabolomics study of the hepatoprotective effect of Phellinus igniarius in chronic ethanol-induced liver injury mice using UPLC-Q/TOF-MS combined with ingenuity pathway analysis, Phytomedicine, 74, 2020. Crossref
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Dong Yu, Qiu Ping, Zhu Rui, Zhao Lisha, Zhang Pinghu, Wang Yiqi, Li Changyu, Chai Kequn, Shou Dan, Zhao Huajun, A Combined Phytochemistry and Network Pharmacology Approach to Reveal the Potential Antitumor Effective Substances and Mechanism of Phellinus igniarius, Frontiers in Pharmacology, 10, 2019. Crossref
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Qiu Ping, Liu Jingqun, Zhao Lisha, Zhang Pinghu, Wang Weike, Shou Dan, Ji Jinjun, Li Changyu, Chai Kequn, Dong Yu, Inoscavin A, a pyrone compound isolated from a Sanghuangporus vaninii extract, inhibits colon cancer cell growth and induces cell apoptosis via the hedgehog signaling pathway, Phytomedicine, 96, 2022. Crossref
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Dong Haoran, Chen Hui, Xu Bing, Tan Yingru, Ling Qun, Shi Liang, Citric Acid Changes the Fingerprint of Flavonoids and Promotes Their Accumulation in Phellinus igniarius (L.) Quél, Life, 13, 1, 2022. Crossref