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International Journal of Medicinal Mushrooms
Главный редактор: Solomon P. Wasser (open in a new tab)

Выходит 12 номеров в год

ISSN Печать: 1521-9437

ISSN Онлайн: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Inhibitory Effects of a Polysaccharide Extract from the Chaga Medicinal Mushroom, Inonotus obliquus (Higher Basidiomycetes), on the Proliferation of Human Neurogliocytoma Cells

Том 16, Выпуск 1, 2014, pp. 29-36
DOI: 10.1615/IntJMedMushr.v16.i1.30
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Краткое описание

This study aimed to investigate the inhibitory roles of a polysaccharide extract from Inonotus obliquus on U251 human neurogliocytoma cells cultured in vitro. After administering the polysaccharide extract from I. obliquus to U251 cells cultivated in vitro, methyl thiazolyl tetrazoliym assay was performed to measure the inhibitory effects of the extract on tumor cell proliferation. The expression of the apoptosis-related proteins Bcl-2 and caspase-3 were determined by Western blotting. Different concentrations of I. obliquus extract (25, 50, 100, 200, and 500 µg/mL) were added to U251 cells at 24, 48, and 72 hours. Methyl thiazolyl tetrazoliym assay showed that the inhibition ratio increased with increased extract concentration and prolonged treatment duration. The I. obliquus extract sharply decreased the expression of Bcl-2 but dramatically increased the expression of caspase-3. This function was gradually enhanced with increased drug concentration and prolonged treatment duration. The I. obliquus extract can inhibit the proliferation of tumor cells. This inhibition function is closely related to the downregulation of Bcl-2 and the upregulation of caspase-3.

ЦИТИРОВАНО В
  1. Liang Zengenni, Guo Yu-Tong, Yi You-Jin, Wang Ren-Cai, Hu Qiu-Long, Xiong Xing-Yao, Ganoderma Lucidum Polysaccharides Target a Fas/Caspase Dependent Pathway to Induce Apoptosis in Human Colon Cancer Cells, Asian Pacific Journal of Cancer Prevention, 15, 9, 2014. Crossref

  2. Lau Beng Fye, Abdullah Noorlidah, Sclerotium-Forming Mushrooms as an Emerging Source of Medicinals, in Mushroom Biotechnology, 2016. Crossref

  3. Ghedira K., Goetz P., Chaga: Inonotus obliquus (Hymenochaetaceae), Phytothérapie, 16, 5, 2018. Crossref

  4. Parfenov A. A., Vyshtakalyuk A. B., Sysoeva M. A., Sysoeva E. V., Latipova A. D., Gumarova L. F., Zobov V. V., Hepatoprotective Effect of Inonotus obliquus Melanins: In Vitro and In Vivo Studies, BioNanoScience, 9, 2, 2019. Crossref

  5. Patel Seema, Immunomodulatory Aspects of Medicinal Mushrooms, in Medicinal Mushrooms, 2019. Crossref

  6. Eid Jehane Ibrahim, Das Biswadeep, Molecular insights and cell cycle assessment upon exposure to Chaga (Inonotus obliquus) mushroom polysaccharides in zebrafish (Danio rerio), Scientific Reports, 10, 1, 2020. Crossref

  7. Badalyan Susanna M., Rapior Sylvie, The Neurotrophic and Neuroprotective Potential of Macrofungi, in Medicinal Herbs and Fungi, 2021. Crossref

  8. Zhao Yanxia, Zheng Weifa, Deciphering the antitumoral potential of the bioactive metabolites from medicinal mushroom Inonotus obliquus, Journal of Ethnopharmacology, 265, 2021. Crossref

  9. Razumov E, Safin R, Mukhametzyanov S R, Hučko Boris, Martin Pavlik, Gomba Gordon Karikoga, Bazant Vaclav, Influence of development conditions on qualitative indicators of Fungus Chaga, IOP Conference Series: Materials Science and Engineering, 666, 1, 2019. Crossref

  10. Li Jiawei, Qu Chao, Li Fangfang, Chen Yifang, Zheng Jinjuan, Xiao Yao, Jin Quanxin, Jin Guihua, Huang Xuezhu, Jin Dan, Inonotus obliquus Polysaccharide Ameliorates Azoxymethane/Dextran Sulfate Sodium-Induced Colitis-Associated Cancer in Mice via Activation of the NLRP3 Inflammasome, Frontiers in Pharmacology, 11, 2021. Crossref

  11. Kothari Damini, Patel Seema, Kim Soo-Ki, Anticancer and other therapeutic relevance of mushroom polysaccharides: A holistic appraisal, Biomedicine & Pharmacotherapy, 105, 2018. Crossref

  12. Nowakowski Patryk, Markiewicz-Żukowska Renata, Bielecka Joanna, Mielcarek Konrad, Grabia Monika, Socha Katarzyna, Treasures from the forest: Evaluation of mushroom extracts as anti-cancer agents, Biomedicine & Pharmacotherapy, 143, 2021. Crossref

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