Выходит 12 номеров в год
ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344
Indexed in
Cell Proliferation and DNA Repair Ability of Ganoderma neo-japonicum (Agaricomycetes): An Indigenous Medicinal Mushroom from Malaysia
Краткое описание
Ganoderma neo-japonicum is an annual polypore that grows on decaying bamboo in the forests of Malaysia. The indigenous Temuan tribe uses this species as a medicinal mushroom to cure fever and epilepsy and to improve body strength. The potential use of G. neo-japonicum in genoprotection and DNA repair was established using a single-cell gel electrophoresis (comet) assay. The effects of the ethanol and hot aqueous extracts from wild and cultivated basidiocarps, solid substrate-fermented (SSF) wheat grains, and mycelia via submerged culture on H2O2-damaged murine RAW264.7 macrophages were investigated. An ethanol extract from wild basidiocarps showed the most significant protective effect on murine RAW264.7 macrophages, followed by ethanol and hot water extracts of cultivated basidiocarps, and this effect was dose dependent. However, only the ethanol extracts from SSF and submerged culture showed significant protective effects compared with the control. As for DNA repair ability, only the ethanol extract from wild and cultivated basidiocarps showed significant results when compared with the negative control. The findings suggest the potential therapeutic use of G. neo-japonicum in genome protection and as a DNA repair stimulator.
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Živković Lada, Bajić Vladan, Topalović Dijana, Bruić Marija, Spremo-Potparević Biljana, Antigenotoxic Effects of Biochaga and Dihydroquercetin (Taxifolin) on H2O2-Induced DNA Damage in Human Whole Blood Cells, Oxidative Medicine and Cellular Longevity, 2019, 2019. Crossref
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Lau Meng‐Fei, Chua Kek‐Heng, Sabaratnam Vikineswary, Kuppusamy Umah Rani, In vitro and in silico anticancer evaluation of a medicinal mushroom, Ganoderma neo‐japonicum Imazeki, against human colonic carcinoma cells , Biotechnology and Applied Biochemistry, 68, 4, 2021. Crossref
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Gryzenhout Marieka, Ghosh Soumya, Tchotet Tchoumi James Michel, Vermeulen Marcele, Kinge Tonjock Rosemary, Ganoderma: Diversity, Ecological Significances, and Potential Applications in Industry and Allied Sectors, in Industrially Important Fungi for Sustainable Development, 2021. Crossref
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Lau Meng-Fei, Chua Kek-Heng, Sabaratnam Vikineswary, Kuppusamy Umah Rani, In vitro Anti-colorectal Cancer Potential of the Medicinal Mushroom Ganoderma neo-japonicum Imazeki in Hyperglycemic Condition: Impact on Oxidative Stress, Cell Cycle and Apoptosis, Nutrition and Cancer, 74, 3, 2022. Crossref