Выходит 12 номеров в год
ISSN Печать: 1521-9437
ISSN Онлайн: 1940-4344
Indexed in
Cancer without Pharmacological Illusions and a Niche for Mycotherapy (Review)
Краткое описание
In this review we outline a framework in which mycotherapy is effective in the field of oncology. We suppose that irreversible epigenomic changes in cancer cells and achieving their replicative immortality when cancer-specific targets are absent should take away any illusions about a fundamental possibility of pharmacological blockage of the cancer process once ontogenesis begins. At the same time, however, we believe that effects of both traditional and alternative medicines on cancer clonogenic units within a particular range can lead to prolonged remission; with this in mind, we carefully consider the various possibilities of mycotherapy in controlling cancer activity. The aforementioned range is limited to nondisseminated cancer processes and depends on the absence of large secondary tumor nodes and the inexhaustibility of immune depots after chemotherapeutic treatment. The main therapeutic effect of fungal bioactive complexes is dectin-1-mediated immunity, including the reprogramming of dendritic cells, which significantly increases the period during which tumors generate immune tolerance. An inhibitory effect of fungal bioactive complexes on some molecular mediators of proliferative signaling and components of proinflammatory (synergistic with cancer) immunity can be considered less significant. The effect of fungal bioactive complexes on vital (including overexpressed) targets of cancer cells is even more limited. The results of this study stress that mycotherapy is only one of the tools that can be used to balance remission. Palliative mycotherapy is associated with polyphenols composites, which contribute to detoxification and to the suppression of inflammation and pain sensation.
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Vedenicheva N., Al-Maali G., Bisko N., Kosakivska I., Garmanchuk L., Ostapchenko L., Effect of bioactive extracts with high cytokinin content from micelial biomass of Hericium coralloides and Fomitopsis officinalis on tumor cells in vitro, Bulletin of Taras Shevchenko National University of Kyiv. Series: Biology, 79, 3, 2019. Crossref
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Zmitrovich Ivan V., Denisova Nina P., Balandaykin Mikhail Eduardovich, Belova Nina V., Bondartseva Margarita A., Perevedentseva Lidiya G., Perelygin Vladimir, Yakovlev Gennady Pavlovich, Chaga and its bioactive complexes: history and perspectives, Pharmacy Formulas, 2, 2, 2020. Crossref
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Roda Elisa, Luca Fabrizio De, Locatelli Carlo Alessandro, Ratto Daniela, Di Iorio Carmine, Savino Elena, Bottone Maria Grazia, Rossi Paola, From a Medicinal Mushroom Blend a Direct Anticancer Effect on Triple-Negative Breast Cancer: A Preclinical Study on Lung Metastases, Molecules, 25, 22, 2020. Crossref
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Jakopovic Boris, Horvatić Anita, Klobučar Marko, Gelemanović Andrea, Grbčić Petra, Oršolić Nada, Jakopovich Ivan, Kraljević Pavelić Sandra, Treatment With Medicinal Mushroom Extract Mixture Inhibits Translation and Reprograms Metabolism in Advanced Colorectal Cancer Animal Model as Evidenced by Tandem Mass Tags Proteomics Analysis, Frontiers in Pharmacology, 11, 2020. Crossref
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Brendler Thomas, Al‐Harrasi Ahmed, Bauer Rudolf, Gafner Stefan, Hardy Mary L., Heinrich Michael, Hosseinzadeh Hossein, Izzo Angelo A., Michaelis Martin, Nassiri‐Asl Marjan, Panossian Alexander, Wasser Solomon P., Williamson Elizabeth M., Botanical drugs and supplements affecting the immune response in the time of COVID ‐19: Implications for research and clinical practice , Phytotherapy Research, 35, 6, 2021. Crossref
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Zmitrovich Ivan V., Vlasenko Vyacheslav A., Perelygin Vladimir V., Figurin Igor S., Prevention and treatment of cancer using so-called medicinal mushrooms raw materials: Criticism, facts, and perspectives, Pharmacy Formulas, 2020. Crossref
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Vedenicheva N., Al-Maali G., Коt L., Ostapchenko L., Garmanchuk L., The glucose level and gamma-glutamyl transpeptidase activity in hepatocyte-like cells under the action of extracts and cytokinin fractions of medicinal mushrooms, Bulletin of Taras Shevchenko National University of Kyiv. Series: Biology, 87, 2021. Crossref
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Plácido Ana Isabel, Roque Fátima, Morgado Manuel, The Promising Role of Mushrooms as a Therapeutic Adjuvant of Conventional Cancer Therapies, Biologics, 2, 1, 2022. Crossref
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Huang Chi-Wei , Hung Yu-Ching , Chen Liang-Yin , Asatiani Mikheil, Klarsfeld Gadi , Melamed Dobroslav , Fares Basem , Wasser Solomon P., Mau Jeng-Leun, Antioxidant Activities of Hot Water Extracts from Mycelial Biomass of Different Combinations of Medicinal Agaricomycetes Mushrooms , International Journal of Medicinal Mushrooms, 24, 8, 2022. Crossref
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Storsberg Joachim , Krüger-Genge Anne , Kalitukha Liudmila, In Vitro Cytotoxic Activity of an Aqueous Alkali Extract of the Tinder Conk Mushroom, Fomes fomentarius (Agaricomycetes), on Murine Fibroblasts, Human Colorectal Adenocarcinoma, and Cutaneous Melanoma Cells , International Journal of Medicinal Mushrooms, 24, 9, 2022. Crossref